MCL coexpression mm9:2665

Phase1 CAGE Peaks

	Short description
Mm9::chr11:3763898..3763913,-	p2@Osbp2
Mm9::chr1:174259448..174259457,-	p2@Kcnj9
Mm9::chr7:16715105..16715194,+	p2@Slc8a2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0015467	G-protein activated inward rectifier potassium channel activity	0.0136734947147237
GO:0005432	calcium:sodium antiporter activity	0.0136734947147237
GO:0015368	calcium:cation antiporter activity	0.0136734947147237
GO:0030001	metal ion transport	0.0136734947147237
GO:0008324	cation transmembrane transporter activity	0.0136734947147237
GO:0006812	cation transport	0.0136734947147237
GO:0006810	transport	0.0136734947147237
GO:0015491	cation:cation antiporter activity	0.0136734947147237
GO:0051234	establishment of localization	0.0136734947147237
GO:0005242	inward rectifier potassium channel activity	0.0137961185645107
GO:0051179	localization	0.0147758858641532
GO:0015298	solute:cation antiporter activity	0.0147758858641532
GO:0015075	ion transmembrane transporter activity	0.0147758858641532
GO:0015300	solute:solute antiporter activity	0.0147758858641532
GO:0006811	ion transport	0.0167436859806347
GO:0022891	substrate-specific transmembrane transporter activity	0.0167436859806347
GO:0005887	integral to plasma membrane	0.018698688541823
GO:0031226	intrinsic to plasma membrane	0.018698688541823
GO:0022857	transmembrane transporter activity	0.018698688541823
GO:0015297	antiporter activity	0.018698688541823
GO:0022892	substrate-specific transporter activity	0.0203986913227776
GO:0006869	lipid transport	0.033037647344639
GO:0005249	voltage-gated potassium channel activity	0.0354271221175463
GO:0006816	calcium ion transport	0.0404093888106348
GO:0005516	calmodulin binding	0.0404093888106348
GO:0030955	potassium ion binding	0.0404093888106348
GO:0044459	plasma membrane part	0.0404093888106348
GO:0022843	voltage-gated cation channel activity	0.0405974668135945
GO:0005267	potassium channel activity	0.0412114347041476
GO:0015674	di-, tri-valent inorganic cation transport	0.0434034188796974
GO:0008202	steroid metabolic process	0.0441970131025135
GO:0006813	potassium ion transport	0.0467582099443818
GO:0005244	voltage-gated ion channel activity	0.0479976399891441
GO:0022832	voltage-gated channel activity	0.0479976399891441
GO:0015291	secondary active transmembrane transporter activity	0.0480191429561284
GO:0031420	alkali metal ion binding	0.0480191429561284
GO:0005886	plasma membrane	0.0486374730126832

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	2.56e-09	23
neuroblast (sensu Vertebrata)	2.56e-09	23
neuron	9.53e-09	33
neuronal stem cell	9.53e-09	33
neuroblast	9.53e-09	33
electrically signaling cell	9.53e-09	33
ectodermal cell	2.20e-07	44
neurectodermal cell	2.20e-07	44
neural cell	2.67e-07	43

Uber Anatomy

Ontology term	p-value	n
central nervous system	6.95e-23	73
nervous system	1.00e-21	75
regional part of nervous system	1.68e-21	54
structure with developmental contribution from neural crest	5.16e-21	92
ectoderm-derived structure	9.04e-21	95
ectoderm	9.04e-21	95
presumptive ectoderm	9.04e-21	95
neurectoderm	9.44e-21	64
neural plate	9.44e-21	64
presumptive neural plate	9.44e-21	64
neural tube	2.65e-20	52
neural rod	2.65e-20	52
future spinal cord	2.65e-20	52
neural keel	2.65e-20	52
ecto-epithelium	1.07e-18	73
brain	1.02e-17	47
future brain	1.02e-17	47
regional part of brain	4.67e-17	46
pre-chordal neural plate	3.10e-15	49
gray matter	5.53e-15	34
anterior neural tube	1.91e-14	40
regional part of forebrain	6.42e-14	39
forebrain	6.42e-14	39
future forebrain	6.42e-14	39
brain grey matter	1.78e-12	29
regional part of telencephalon	1.78e-12	29
telencephalon	1.78e-12	29
cerebral cortex	1.61e-08	21
cerebral hemisphere	1.61e-08	21
pallium	1.61e-08	21
anatomical conduit	5.36e-08	122
regional part of cerebral cortex	5.67e-08	17
multi-cellular organism	6.79e-08	333
occipital lobe	8.38e-08	10
visual cortex	8.38e-08	10
neocortex	8.38e-08	10
tube	2.13e-07	114

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}