MCL coexpression mm9:1616

Phase1 CAGE Peaks

	Short description
Mm9::chr12:120476799..120476810,-	p12@Itgb8
Mm9::chr8:48072237..48072245,+	p3@Enpp6
Mm9::chr8:48072252..48072264,+	p2@Enpp6
Mm9::chr8:48072267..48072316,+	p1@Enpp6
Mm9::chr8:48180161..48180170,+	p@chr8:48180161..48180170 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0019695	choline metabolic process	0.0098589613379595
GO:0042439	ethanolamine and derivative metabolic process	0.0098589613379595
GO:0008889	glycerophosphodiester phosphodiesterase activity	0.0098589613379595
GO:0001573	ganglioside metabolic process	0.0098589613379595
GO:0006629	lipid metabolic process	0.0098589613379595
GO:0006687	glycosphingolipid metabolic process	0.0098589613379595
GO:0006664	glycolipid metabolic process	0.0135186383516479
GO:0006672	ceramide metabolic process	0.0164248485915314
GO:0046519	sphingoid metabolic process	0.0164248485915314
GO:0008305	integrin complex	0.0200990548039927
GO:0006665	sphingolipid metabolic process	0.0225661800323921
GO:0007160	cell-matrix adhesion	0.0265739732497567
GO:0008081	phosphoric diester hydrolase activity	0.0265739732497567
GO:0031589	cell-substrate adhesion	0.0265739732497567
GO:0043235	receptor complex	0.0265739732497567
GO:0006576	biogenic amine metabolic process	0.0265739732497567
GO:0006575	amino acid derivative metabolic process	0.0288883626643423
GO:0007229	integrin-mediated signaling pathway	0.0288883626643423
GO:0016042	lipid catabolic process	0.0288883626643423
GO:0005886	plasma membrane	0.0289955740435956
GO:0006643	membrane lipid metabolic process	0.0423700426692558
GO:0009117	nucleotide metabolic process	0.0484393834823058
GO:0055086	nucleobase, nucleoside and nucleotide metabolic process	0.0496433578567692

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
tube	4.60e-10	114
compound organ	2.66e-09	43
anatomical conduit	1.08e-08	122
structure with developmental contribution from neural crest	1.81e-08	92
occipital lobe	1.69e-07	10
visual cortex	1.69e-07	10
neocortex	1.69e-07	10
primary circulatory organ	2.59e-07	18
heart	2.59e-07	18
primitive heart tube	2.59e-07	18
primary heart field	2.59e-07	18
anterior lateral plate mesoderm	2.59e-07	18
heart tube	2.59e-07	18
heart primordium	2.59e-07	18
cardiac mesoderm	2.59e-07	18
cardiogenic plate	2.59e-07	18
heart rudiment	2.59e-07	18

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}