MCL coexpression mm9:1113

Phase1 CAGE Peaks

	Short description
Mm9::chr13:31898496..31898519,+	p3@Foxc1
Mm9::chr13:31898529..31898542,+	p5@Foxc1
Mm9::chr13:31898637..31898653,+	p2@Foxc1
Mm9::chr13:31898729..31898761,+	p1@Foxc1
Mm9::chr13:31900702..31900717,+	p@chr13:31900702..31900717 +
Mm9::chr13:31911932..31911937,+	p@chr13:31911932..31911937 +
Mm9::chr1:95132413..95132419,+	p1@Sned1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0032808	lacrimal gland development	0.0132190355174424
GO:0008301	DNA bending activity	0.0132190355174424
GO:0048844	artery morphogenesis	0.0132190355174424
GO:0055010	ventricular cardiac muscle morphogenesis	0.0132190355174424
GO:0001945	lymph vessel development	0.0132190355174424
GO:0048341	paraxial mesoderm formation	0.0132190355174424
GO:0055008	cardiac muscle morphogensis	0.0132190355174424
GO:0008354	germ cell migration	0.0132190355174424
GO:0046620	regulation of organ growth	0.0132190355174424
GO:0048644	muscle morphogenesis	0.0132190355174424
GO:0014855	striated muscle cell proliferation	0.0132190355174424
GO:0060038	cardiac muscle cell proliferation	0.0132190355174424
GO:0048340	paraxial mesoderm morphogenesis	0.0137270838347131
GO:0035265	organ growth	0.014160535876671
GO:0033002	muscle cell proliferation	0.014160535876671
GO:0048339	paraxial mesoderm development	0.014160535876671
GO:0035050	embryonic heart tube development	0.014160535876671
GO:0035272	exocrine system development	0.014160535876671
GO:0048010	vascular endothelial growth factor receptor signaling pathway	0.014160535876671
GO:0030199	collagen fibril organization	0.014160535876671
GO:0001974	blood vessel remodeling	0.014160535876671
GO:0001541	ovarian follicle development	0.0150651585630029
GO:0006022	aminoglycan metabolic process	0.0150651585630029
GO:0030203	glycosaminoglycan metabolic process	0.0150651585630029
GO:0003705	RNA polymerase II transcription factor activity, enhancer binding	0.0150651585630029
GO:0001707	mesoderm formation	0.0178320069727805
GO:0048332	mesoderm morphogenesis	0.0178320069727805
GO:0001704	formation of primary germ layer	0.0178320069727805
GO:0022601	menstrual cycle phase	0.0178320069727805
GO:0022602	menstrual cycle process	0.0178320069727805
GO:0014032	neural crest cell development	0.0178320069727805
GO:0014033	neural crest cell differentiation	0.0178320069727805
GO:0001657	ureteric bud development	0.0178320069727805
GO:0003007	heart morphogenesis	0.0178320069727805
GO:0003018	vascular process in circulatory system	0.0178320069727805
GO:0035150	regulation of tube size	0.0178320069727805
GO:0050880	regulation of blood vessel size	0.0178320069727805
GO:0008585	female gonad development	0.0178320069727805
GO:0046545	development of primary female sexual characteristics	0.0178320069727805
GO:0046660	female sex differentiation	0.0178320069727805
GO:0048762	mesenchymal cell differentiation	0.0183965889740283
GO:0014031	mesenchymal cell development	0.0183965889740283
GO:0042698	menstrual cycle	0.018428993404754
GO:0001656	metanephros development	0.020258643524998
GO:0007498	mesoderm development	0.021490739919511
GO:0007219	Notch signaling pathway	0.021490739919511
GO:0008406	gonad development	0.021490739919511
GO:0048608	reproductive structure development	0.0218670327202715
GO:0030198	extracellular matrix organization and biogenesis	0.0229696108243786
GO:0045137	development of primary sexual characteristics	0.0229696108243786
GO:0007369	gastrulation	0.0239868528313534
GO:0007160	cell-matrix adhesion	0.0239868528313534
GO:0031589	cell-substrate adhesion	0.0246583985634568
GO:0048609	reproductive process in a multicellular organism	0.0246583985634568
GO:0032504	multicellular organism reproduction	0.0246583985634568
GO:0001822	kidney development	0.0246583985634568
GO:0007548	sex differentiation	0.0246583985634568
GO:0048732	gland development	0.0246583985634568
GO:0048729	tissue morphogenesis	0.0246583985634568
GO:0043010	camera-type eye development	0.0246583985634568
GO:0003702	RNA polymerase II transcription factor activity	0.0246583985634568
GO:0006916	anti-apoptosis	0.0248160060337054
GO:0001655	urogenital system development	0.0248160060337054
GO:0003006	reproductive developmental process	0.0265876745998625
GO:0001503	ossification	0.0276356212817596
GO:0031214	biomineral formation	0.0276356212817596
GO:0008015	blood circulation	0.0276356212817596
GO:0003013	circulatory system process	0.0276356212817596
GO:0043062	extracellular structure organization and biogenesis	0.0283787282681677
GO:0046849	bone remodeling	0.0289682437536967
GO:0001654	eye development	0.0289682437536967
GO:0001701	in utero embryonic development	0.0326725206490609
GO:0048771	tissue remodeling	0.0327647466503692
GO:0035239	tube morphogenesis	0.0387242158163404
GO:0040008	regulation of growth	0.0387242158163404
GO:0043066	negative regulation of apoptosis	0.0387242158163404
GO:0043069	negative regulation of programmed cell death	0.0387322107229055
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.0412606140285013
GO:0007517	muscle development	0.0414846881416702
GO:0007507	heart development	0.0419486472036053
GO:0048514	blood vessel morphogenesis	0.0421584126785717
GO:0001501	skeletal development	0.0431779244119272
GO:0007420	brain development	0.0431779244119272
GO:0007423	sensory organ development	0.0431779244119272
GO:0048646	anatomical structure formation	0.0431779244119272
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	0.0451391350298262
GO:0035295	tube development	0.0451391350298262
GO:0001568	blood vessel development	0.0451391350298262
GO:0022414	reproductive process	0.0451391350298262
GO:0001944	vasculature development	0.0451391350298262
GO:0043009	chordate embryonic development	0.0478740204096205
GO:0009792	embryonic development ending in birth or egg hatching	0.0479924919607441
GO:0007417	central nervous system development	0.0489506362419057
GO:0045893	positive regulation of transcription, DNA-dependent	0.0494713306399622

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

---

Uber Anatomy

Ontology term	p-value	n
compound organ	2.71e-11	43
structure with developmental contribution from neural crest	6.98e-11	92
surface structure	2.77e-07	22
ecto-epithelium	3.06e-07	73
cardiovascular system	5.96e-07	23
circulatory system	5.96e-07	23

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}