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MCL coexpression mm9:3341

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Phase1 CAGE Peaks

 Short description
Mm9::chr2:27532754..27532815,+p1@Rxra
Mm9::chr4:59015993..59016087,+p1@Dnajc25
Mm9::chr7:35904304..35904320,+p1@Cebpa


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0055010ventricular cardiac muscle morphogenesis0.0126591132027072
GO:0043565sequence-specific DNA binding0.0126591132027072
GO:0008283cell proliferation0.0126591132027072
GO:0055008cardiac muscle morphogensis0.0126591132027072
GO:0055012ventricular cardiac muscle cell differentiation0.0126591132027072
GO:0009887organ morphogenesis0.0126591132027072
GO:0048644muscle morphogenesis0.0126591132027072
GO:0014855striated muscle cell proliferation0.0126591132027072
GO:0060038cardiac muscle cell proliferation0.0126591132027072
GO:0030225macrophage differentiation0.0128170009285442
GO:0055007cardiac muscle cell differentiation0.0129461108478256
GO:0001892embryonic placenta development0.0130536374121903
GO:0033002muscle cell proliferation0.0142387708815145
GO:0016439tRNA-pseudouridine synthase activity0.0142387708815145
GO:0035051cardiac cell differentiation0.0142387708815145
GO:0003700transcription factor activity0.0150751061479676
GO:0009982pseudouridine synthase activity0.0150751061479676
GO:0001889liver development0.0166091678902358
GO:0045444fat cell differentiation0.0172326279786625
GO:0001890placenta development0.0187620877370507
GO:0051146striated muscle cell differentiation0.0187620877370507
GO:0016866intramolecular transferase activity0.0187620877370507
GO:0009653anatomical structure morphogenesis0.0208469300387484
GO:0002573myeloid leukocyte differentiation0.0235463072181457
GO:0019221cytokine and chemokine mediated signaling pathway0.0235463072181457
GO:0005496steroid binding0.0235463072181457
GO:0003707steroid hormone receptor activity0.0235463072181457
GO:0048513organ development0.0235463072181457
GO:0004879ligand-dependent nuclear receptor activity0.0235463072181457
GO:0042692muscle cell differentiation0.0288678229290731
GO:0030324lung development0.0288678229290731
GO:0030323respiratory tube development0.0288678229290731
GO:0007005mitochondrion organization and biogenesis0.0288678229290731
GO:0048731system development0.02964176031617
GO:0048469cell maturation0.02964176031617
GO:0048869cellular developmental process0.02964176031617
GO:0030154cell differentiation0.02964176031617
GO:0006355regulation of transcription, DNA-dependent0.0304539565209044
GO:0006351transcription, DNA-dependent0.0304539565209044
GO:0021700developmental maturation0.0304539565209044
GO:0032774RNA biosynthetic process0.0304539565209044
GO:0030099myeloid cell differentiation0.0304539565209044
GO:0003677DNA binding0.0304539565209044
GO:0045449regulation of transcription0.0304539565209044
GO:0048856anatomical structure development0.0304539565209044
GO:0019219regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0304539565209044
GO:0042803protein homodimerization activity0.0304539565209044
GO:0006350transcription0.0304539565209044
GO:0010468regulation of gene expression0.0318698223543611
GO:0008285negative regulation of cell proliferation0.0324950346864553
GO:0001701in utero embryonic development0.0324950346864553
GO:0031323regulation of cellular metabolic process0.0324950346864553
GO:0014706striated muscle development0.0324950346864553
GO:0007275multicellular organismal development0.0324950346864553
GO:0002521leukocyte differentiation0.0324950346864553
GO:0019222regulation of metabolic process0.0324950346864553
GO:0016070RNA metabolic process0.033632506275792
GO:0016853isomerase activity0.0371753006275059
GO:0007517muscle development0.0398958467286218
GO:0007507heart development0.0399759238503913
GO:0042802identical protein binding0.0399759238503913
GO:0010467gene expression0.0436288842760839
GO:0045944positive regulation of transcription from RNA polymerase II promoter0.0436288842760839
GO:0046983protein dimerization activity0.0436288842760839
GO:0035295tube development0.0436288842760839
GO:0003676nucleic acid binding0.0436288842760839
GO:0030097hemopoiesis0.0439701454378248
GO:0032502developmental process0.0451014840833114
GO:0043009chordate embryonic development0.0453030942265587
GO:0009792embryonic development ending in birth or egg hatching0.0453030942265587
GO:0048534hemopoietic or lymphoid organ development0.0458109790184307
GO:0045893positive regulation of transcription, DNA-dependent0.0458109790184307
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.0458109790184307
GO:0002520immune system development0.0476042967688176



Relative expression of the co-expression cluster over median <br>Analyst:





Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs




JASPAR motifs


Motifs-log10(p-value)

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