MCL coexpression mm9:1239

Phase1 CAGE Peaks

	Short description
Mm9::chr10:29033033..29033044,+	p4@Echdc1
Mm9::chr11:120677718..120677738,-	p@chr11:120677718..120677738 -
Mm9::chr11:120678463..120678477,-	p@chr11:120678463..120678477 -
Mm9::chr11:120679899..120679911,-	p@chr11:120679899..120679911 -
Mm9::chr11:120681605..120681624,-	p@chr11:120681605..120681624 -
Mm9::chr11:120685412..120685430,-	p1@Fasn

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004317	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity	0.000803498870553531
GO:0004319	enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity	0.000803498870553531
GO:0019171	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	0.000803498870553531
GO:0016631	enoyl-[acyl-carrier-protein] reductase activity	0.000803498870553531
GO:0004313	[acyl-carrier-protein] S-acetyltransferase activity	0.000803498870553531
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase activity	0.000803498870553531
GO:0004314	[acyl-carrier-protein] S-malonyltransferase activity	0.000803498870553531
GO:0016418	S-acetyltransferase activity	0.000803498870553531
GO:0031177	phosphopantetheine binding	0.000803498870553531
GO:0016419	S-malonyltransferase activity	0.000803498870553531
GO:0042587	glycogen granule	0.000803498870553531
GO:0016297	acyl-[acyl-carrier-protein] hydrolase activity	0.000803498870553531
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity	0.000803498870553531
GO:0004320	oleoyl-[acyl-carrier-protein] hydrolase activity	0.000803498870553531
GO:0016420	malonyltransferase activity	0.000803498870553531
GO:0016417	S-acyltransferase activity	0.00177227831245159
GO:0004312	fatty-acid synthase activity	0.00177227831245159
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	0.00502007947745704
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	0.0133065681477556
GO:0016836	hydro-lyase activity	0.0147452817551305
GO:0016407	acetyltransferase activity	0.0161360480054141
GO:0016835	carbon-oxygen lyase activity	0.0161360480054141
GO:0006633	fatty acid biosynthetic process	0.0175623990263522
GO:0046394	carboxylic acid biosynthetic process	0.0175623990263522
GO:0016053	organic acid biosynthetic process	0.0175623990263522
GO:0016790	thiolester hydrolase activity	0.0203484562106651
GO:0019842	vitamin binding	0.0233692564329233
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.0236044754148206
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	0.0246491106439858
GO:0016829	lyase activity	0.0301681293013406
GO:0006631	fatty acid metabolic process	0.0301681293013406
GO:0048037	cofactor binding	0.0301681293013406
GO:0008415	acyltransferase activity	0.0301681293013406
GO:0016747	transferase activity, transferring groups other than amino-acyl groups	0.0301681293013406
GO:0016746	transferase activity, transferring acyl groups	0.0304999738833587
GO:0032787	monocarboxylic acid metabolic process	0.0354491625982649
GO:0008610	lipid biosynthetic process	0.0381912467386299

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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