MCL coexpression mm9:55
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0042446 | hormone biosynthetic process | 3.56417079568457e-08 |
| GO:0042445 | hormone metabolic process | 2.10840329094625e-06 |
| GO:0006700 | C21-steroid hormone biosynthetic process | 2.10840329094625e-06 |
| GO:0008207 | C21-steroid hormone metabolic process | 3.74394190205883e-06 |
| GO:0006694 | steroid biosynthetic process | 2.30676219720107e-05 |
| GO:0008202 | steroid metabolic process | 2.4703492496154e-05 |
| GO:0042423 | catecholamine biosynthetic process | 6.01788982740881e-05 |
| GO:0016491 | oxidoreductase activity | 8.50369406184694e-05 |
| GO:0004497 | monooxygenase activity | 0.00022232714303673 |
| GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | 0.00022232714303673 |
| GO:0044255 | cellular lipid metabolic process | 0.000230427847073286 |
| GO:0008610 | lipid biosynthetic process | 0.000258691407179885 |
| GO:0042401 | biogenic amine biosynthetic process | 0.000502733548562387 |
| GO:0006629 | lipid metabolic process | 0.000502733548562387 |
| GO:0042398 | amino acid derivative biosynthetic process | 0.000735344714110311 |
| GO:0018958 | phenol metabolic process | 0.000735344714110311 |
| GO:0006584 | catecholamine metabolic process | 0.000735344714110311 |
| GO:0016713 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen | 0.00105293699857129 |
| GO:0005737 | cytoplasm | 0.00137494794519885 |
| GO:0006066 | alcohol metabolic process | 0.00323296048879968 |
| GO:0008211 | glucocorticoid metabolic process | 0.00323296048879968 |
| GO:0044444 | cytoplasmic part | 0.00353939423639047 |
| GO:0008395 | steroid hydroxylase activity | 0.00368521303300052 |
| GO:0044249 | cellular biosynthetic process | 0.00394323645494978 |
| GO:0009309 | amine biosynthetic process | 0.00427157306512822 |
| GO:0005506 | iron ion binding | 0.00507517074088381 |
| GO:0009058 | biosynthetic process | 0.00522053416229106 |
| GO:0042136 | neurotransmitter biosynthetic process | 0.00522753625285679 |
| GO:0019098 | reproductive behavior | 0.00576242272994915 |
| GO:0005739 | mitochondrion | 0.00576242272994915 |
| GO:0006118 | electron transport | 0.00576242272994915 |
| GO:0006576 | biogenic amine metabolic process | 0.00601551570555625 |
| GO:0044271 | nitrogen compound biosynthetic process | 0.00683875612607725 |
| GO:0007613 | memory | 0.00746903953422422 |
| GO:0006575 | amino acid derivative metabolic process | 0.00957843234628468 |
| GO:0042417 | dopamine metabolic process | 0.00981837768861146 |
| GO:0006091 | generation of precursor metabolites and energy | 0.0159388478715822 |
| GO:0006725 | aromatic compound metabolic process | 0.0188152585478246 |
| GO:0030322 | stabilization of membrane potential | 0.0190780019301358 |
| GO:0003878 | ATP citrate synthase activity | 0.0190780019301358 |
| GO:0006585 | dopamine biosynthetic process from tyrosine | 0.0190780019301358 |
| GO:0008937 | ferredoxin reductase activity | 0.0190780019301358 |
| GO:0004509 | steroid 21-monooxygenase activity | 0.0190780019301358 |
| GO:0050810 | regulation of steroid biosynthetic process | 0.0190780019301358 |
| GO:0016731 | oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor | 0.0190780019301358 |
| GO:0042309 | homoiothermy | 0.0190780019301358 |
| GO:0008386 | cholesterol monooxygenase (side-chain-cleaving) activity | 0.0190780019301358 |
| GO:0016730 | oxidoreductase activity, acting on iron-sulfur proteins as donors | 0.0190780019301358 |
| GO:0004978 | adrenocorticotropin receptor activity | 0.0190780019301358 |
| GO:0004324 | ferredoxin-NADP+ reductase activity | 0.0190780019301358 |
| GO:0004603 | phenylethanolamine N-methyltransferase activity | 0.0190780019301358 |
| GO:0004511 | tyrosine 3-monooxygenase activity | 0.0190780019301358 |
| GO:0042133 | neurotransmitter metabolic process | 0.0228896703526482 |
| GO:0042923 | neuropeptide binding | 0.0244805808941531 |
| GO:0008188 | neuropeptide receptor activity | 0.0244805808941531 |
| GO:0009308 | amine metabolic process | 0.0319711263849887 |
| GO:0005496 | steroid binding | 0.0319711263849887 |
| GO:0046890 | regulation of lipid biosynthetic process | 0.0319711263849887 |
| GO:0046087 | cytidine metabolic process | 0.0319711263849887 |
| GO:0045907 | positive regulation of vasoconstriction | 0.0319711263849887 |
| GO:0047783 | corticosterone 18-monooxygenase activity | 0.0319711263849887 |
| GO:0003951 | NAD+ kinase activity | 0.0319711263849887 |
| GO:0007612 | learning | 0.0335013161563284 |
| GO:0006807 | nitrogen compound metabolic process | 0.0390718621159912 |
| GO:0042787 | protein ubiquitination during ubiquitin-dependent protein catabolic process | 0.0424352107206333 |
| GO:0046131 | pyrimidine ribonucleoside metabolic process | 0.0424352107206333 |
| GO:0048149 | behavioral response to ethanol | 0.0424352107206333 |
| GO:0043204 | perikaryon | 0.0424352107206333 |
| GO:0004995 | tachykinin receptor activity | 0.0424352107206333 |
| GO:0042421 | norepinephrine biosynthetic process | 0.0424352107206333 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
