MCL coexpression mm9:3183

Phase1 CAGE Peaks

	Short description
Mm9::chr19:30700005..30700027,-	p@chr19:30700005..30700027 -
Mm9::chr7:4464440..4464444,-	p@chr7:4464440..4464444 -
Mm9::chr7:4467569..4467584,-	p1@Tnnt1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004692	cGMP-dependent protein kinase activity	0.0174179756208422
GO:0004690	cyclic nucleotide-dependent protein kinase activity	0.0174179756208422
GO:0019002	GMP binding	0.0174179756208422
GO:0030553	cGMP binding	0.0174179756208422
GO:0005861	troponin complex	0.0174179756208422
GO:0005952	cAMP-dependent protein kinase complex	0.0174179756208422
GO:0008603	cAMP-dependent protein kinase regulator activity	0.019904621542287
GO:0005865	striated muscle thin filament	0.0232195130947285
GO:0030551	cyclic nucleotide binding	0.0245074709588446
GO:0006937	regulation of muscle contraction	0.0382943471902504
GO:0016358	dendrite development	0.0411359186902933
GO:0001764	neuron migration	0.0458019258202438
GO:0019887	protein kinase regulator activity	0.0458019258202438
GO:0030017	sarcomere	0.0458019258202438
GO:0043234	protein complex	0.0458019258202438
GO:0044449	contractile fiber part	0.0458019258202438
GO:0019207	kinase regulator activity	0.0458019258202438
GO:0030016	myofibril	0.0458019258202438
GO:0043292	contractile fiber	0.0458019258202438
GO:0003012	muscle system process	0.0458019258202438
GO:0006936	muscle contraction	0.0458019258202438
GO:0005200	structural constituent of cytoskeleton	0.0463473928236306

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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