MCL coexpression mm9:2676

Phase1 CAGE Peaks

	Short description
Mm9::chr11:49526176..49526228,-	p1@Cnot6
Mm9::chr14:31832369..31832400,+	p3@Pbrm1
Mm9::chr8:109620410..109620462,-	p1@Terf2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0042162	telomeric DNA binding	0.0165323101421702
GO:0007004	telomere maintenance via telomerase	0.0165323101421702
GO:0044427	chromosomal part	0.0165323101421702
GO:0006278	RNA-dependent DNA replication	0.0165323101421702
GO:0005694	chromosome	0.0165323101421702
GO:0032200	telomere organization and biogenesis	0.0243021189462064
GO:0000723	telomere maintenance	0.0243021189462064
GO:0000776	kinetochore	0.0243021189462064
GO:0000781	chromosome, telomeric region	0.0243021189462064
GO:0003676	nucleic acid binding	0.0243831369928699
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0273264003957744
GO:0001890	placenta development	0.0273264003957744
GO:0004527	exonuclease activity	0.041999149025466
GO:0000775	chromosome, pericentric region	0.0493230110171752
GO:0005634	nucleus	0.0493230110171752

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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