MCL coexpression mm9:1820

Phase1 CAGE Peaks

	Short description
Mm9::chr6:124789985..124790034,-	p1@Gnb3
Mm9::chr7:130174860..130174906,+	p1@uc009jpa.1
Mm9::chr8:28479265..28479279,+	p1@Chrnb3
Mm9::chr8:28524351..28524364,-	p1@Chrna6
Mm9::chr8:28524409..28524418,-	p2@Chrna6

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007271	synaptic transmission, cholinergic	8.6003638539287e-05
GO:0004889	nicotinic acetylcholine-activated cation-selective channel activity	8.6003638539287e-05
GO:0005231	excitatory extracellular ligand-gated ion channel activity	0.000541929406359434
GO:0005230	extracellular ligand-gated ion channel activity	0.000902009987176167
GO:0015276	ligand-gated ion channel activity	0.000902009987176167
GO:0022834	ligand-gated channel activity	0.000902009987176167
GO:0030594	neurotransmitter receptor activity	0.000902009987176167
GO:0042165	neurotransmitter binding	0.000902009987176167
GO:0045211	postsynaptic membrane	0.00123189256685554
GO:0044456	synapse part	0.0013669119896086
GO:0007268	synaptic transmission	0.00306546162485347
GO:0019226	transmission of nerve impulse	0.00390432643555917
GO:0044459	plasma membrane part	0.00390432643555917
GO:0005261	cation channel activity	0.00390432643555917
GO:0022836	gated channel activity	0.00417251402309012
GO:0046873	metal ion transmembrane transporter activity	0.00466767539808082
GO:0014059	regulation of dopamine secretion	0.0047926820287058
GO:0014046	dopamine secretion	0.0047926820287058
GO:0007267	cell-cell signaling	0.00497758359007022
GO:0050433	regulation of catecholamine secretion	0.00497758359007022
GO:0005216	ion channel activity	0.00497758359007022
GO:0005886	plasma membrane	0.00497758359007022
GO:0022838	substrate specific channel activity	0.00497758359007022
GO:0050432	catecholamine secretion	0.00497758359007022
GO:0022803	passive transmembrane transporter activity	0.00497758359007022
GO:0015267	channel activity	0.00497758359007022
GO:0030054	cell junction	0.0050521666090356
GO:0005892	nicotinic acetylcholine-gated receptor-channel complex	0.00594790648019933
GO:0003993	acid phosphatase activity	0.00594790648019933
GO:0008324	cation transmembrane transporter activity	0.00643070053725156
GO:0051899	membrane depolarization	0.00945546203797659
GO:0046928	regulation of neurotransmitter secretion	0.00969826959635346
GO:0015075	ion transmembrane transporter activity	0.0107477629438982
GO:0004890	GABA-A receptor activity	0.0123374528278361
GO:0006811	ion transport	0.0123374528278361
GO:0060089	molecular transducer activity	0.0123374528278361
GO:0004871	signal transducer activity	0.0123374528278361
GO:0022891	substrate-specific transmembrane transporter activity	0.0123374528278361
GO:0016917	GABA receptor activity	0.0123716352329554
GO:0005834	heterotrimeric G-protein complex	0.0142124383203555
GO:0022857	transmembrane transporter activity	0.0152784281800477
GO:0046879	hormone secretion	0.0168096521810302
GO:0042391	regulation of membrane potential	0.0168182646960398
GO:0022892	substrate-specific transporter activity	0.017037543320729
GO:0019897	extrinsic to plasma membrane	0.0187752593651088
GO:0007269	neurotransmitter secretion	0.0187752593651088
GO:0051046	regulation of secretion	0.0187752593651088
GO:0007154	cell communication	0.0187752593651088
GO:0045055	regulated secretory pathway	0.0224626122373204
GO:0019898	extrinsic to membrane	0.0237266452172607
GO:0043235	receptor complex	0.0242687884136653
GO:0003001	generation of a signal involved in cell-cell signaling	0.0285174909041151
GO:0001505	regulation of neurotransmitter levels	0.0285174909041151
GO:0043234	protein complex	0.0400603620266142
GO:0003924	GTPase activity	0.041739751496872
GO:0055082	cellular chemical homeostasis	0.0437631748158408
GO:0006873	cellular ion homeostasis	0.0437631748158408
GO:0050877	neurological system process	0.0437631748158408
GO:0005083	small GTPase regulator activity	0.0438053474380967
GO:0050801	ion homeostasis	0.0473152438728316
GO:0003008	system process	0.0482476081683852
GO:0045045	secretory pathway	0.0482476081683852

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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