MCL coexpression mm9:423

Phase1 CAGE Peaks

	Short description
Mm9::chr11:116715066..116715150,+	p1@Mfsd11
Mm9::chr12:103677954..103677968,-	p3@Lgmn
Mm9::chr12:8320231..8320260,+	p1@Hs1bp3
Mm9::chr15:89004361..89004407,-	p3@Plxnb2
Mm9::chr2:164659281..164659312,+	p1@Ctsa
Mm9::chr2:25211839..25211886,-	p1@Dpp7
Mm9::chr3:53267122..53267154,-	p2@Nhlrc3
Mm9::chr3:53267156..53267228,-	p1@Nhlrc3
Mm9::chr3:88128952..88128997,+	p1@0610031J06Rik
Mm9::chr5:30950308..30950371,+	p1@4930471M23Rik
Mm9::chr5:31210065..31210126,-	p1@Gm19774 p1@Ost4
Mm9::chr5:37221812..37221885,-	p1@Man2b2
Mm9::chr5:37221886..37221896,-	p2@Man2b2
Mm9::chr7:112900707..112900748,-	p1@Tpp1
Mm9::chr8:87607168..87607196,+	p2@Man2b1
Mm9::chr8:98377401..98377430,-	p1@Slc38a7
Mm9::chr9:106587656..106587694,-	p2@Tex264
Mm9::chr9:106587698..106587716,-	p10@Tex264

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005764	lysosome	3.9790322658491e-08
GO:0000323	lytic vacuole	3.9790322658491e-08
GO:0005773	vacuole	5.35678442454625e-08
GO:0004559	alpha-mannosidase activity	0.00022402824154555
GO:0006013	mannose metabolic process	0.000536882639692648
GO:0008238	exopeptidase activity	0.000708081257451535
GO:0015923	mannosidase activity	0.000774364732215079
GO:0004177	aminopeptidase activity	0.00394371374385564
GO:0017171	serine hydrolase activity	0.00394371374385564
GO:0008236	serine-type peptidase activity	0.00394371374385564
GO:0006508	proteolysis	0.00660720370132939
GO:0004186	carboxypeptidase C activity	0.00680771686289669
GO:0019131	tripeptidyl-peptidase I activity	0.00680771686289669
GO:0043171	peptide catabolic process	0.00680771686289669
GO:0008233	peptidase activity	0.00680771686289669
GO:0016787	hydrolase activity	0.00908076867295631
GO:0008240	tripeptidyl-peptidase activity	0.0110268265042963
GO:0001509	legumain activity	0.0110268265042963
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	0.011419743294679
GO:0016798	hydrolase activity, acting on glycosyl bonds	0.0162810385064759
GO:0004175	endopeptidase activity	0.0162810385064759
GO:0004185	serine carboxypeptidase activity	0.0180330260152798
GO:0019318	hexose metabolic process	0.0203214838823665
GO:0045862	positive regulation of proteolysis	0.0203214838823665
GO:0005996	monosaccharide metabolic process	0.0203214838823665
GO:0040015	negative regulation of multicellular organism growth	0.0324324902690303
GO:0006518	peptide metabolic process	0.0324324902690303
GO:0005615	extracellular space	0.0324324902690303
GO:0004252	serine-type endopeptidase activity	0.033188059845617
GO:0044421	extracellular region part	0.0382839822925629
GO:0050772	positive regulation of axonogenesis	0.0382839822925629
GO:0044444	cytoplasmic part	0.0382839822925629
GO:0030162	regulation of proteolysis	0.0389657680671849
GO:0004289	subtilase activity	0.0400757626685785
GO:0007040	lysosome organization and biogenesis	0.0400757626685785
GO:0045453	bone resorption	0.0400757626685785
GO:0050769	positive regulation of neurogenesis	0.0400757626685785
GO:0044262	cellular carbohydrate metabolic process	0.0440792899334869
GO:0006066	alcohol metabolic process	0.0449581600631616
GO:0007033	vacuole organization and biogenesis	0.0468989193720354

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n

Uber Anatomy

Ontology term	p-value	n

Disease

Ontology term	p-value	n

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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