MCL coexpression mm9:183
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0001503 | ossification | 9.39167572983397e-08 |
| GO:0031214 | biomineral formation | 9.39167572983397e-08 |
| GO:0001501 | skeletal development | 9.39167572983397e-08 |
| GO:0046849 | bone remodeling | 1.12070436394931e-07 |
| GO:0048771 | tissue remodeling | 2.37740323321377e-07 |
| GO:0030282 | bone mineralization | 6.39853335032151e-07 |
| GO:0005615 | extracellular space | 1.67176511208622e-06 |
| GO:0044421 | extracellular region part | 2.94148392710855e-06 |
| GO:0009888 | tissue development | 1.97297292138458e-05 |
| GO:0005578 | proteinaceous extracellular matrix | 0.000397389940734604 |
| GO:0030500 | regulation of bone mineralization | 0.0021230096364638 |
| GO:0030574 | collagen catabolic process | 0.0021230096364638 |
| GO:0044259 | multicellular organismal macromolecule metabolic process | 0.0021230096364638 |
| GO:0044268 | multicellular organismal protein metabolic process | 0.0021230096364638 |
| GO:0044256 | protein digestion | 0.0021230096364638 |
| GO:0044254 | multicellular organismal protein catabolic process | 0.0021230096364638 |
| GO:0044266 | multicellular organismal macromolecule catabolic process | 0.0021230096364638 |
| GO:0044243 | multicellular organismal catabolic process | 0.0021230096364638 |
| GO:0032963 | collagen metabolic process | 0.00256062945348381 |
| GO:0044236 | multicellular organismal metabolic process | 0.00271680136502611 |
| GO:0004222 | metalloendopeptidase activity | 0.00290623633204116 |
| GO:0030278 | regulation of ossification | 0.00397184911185981 |
| GO:0001649 | osteoblast differentiation | 0.00482097140514813 |
| GO:0046850 | regulation of bone remodeling | 0.00512279925182716 |
| GO:0030020 | extracellular matrix structural constituent conferring tensile strength | 0.00512279925182716 |
| GO:0048513 | organ development | 0.0059725965513933 |
| GO:0005581 | collagen | 0.00692106639459702 |
| GO:0007586 | digestion | 0.00871710445467921 |
| GO:0048856 | anatomical structure development | 0.00873828959623076 |
| GO:0004216 | cathepsin K activity | 0.00873828959623076 |
| GO:0004991 | parathyroid hormone receptor activity | 0.00873828959623076 |
| GO:0004229 | gelatinase B activity | 0.00873828959623076 |
| GO:0004175 | endopeptidase activity | 0.00993151401688284 |
| GO:0008237 | metallopeptidase activity | 0.00993151401688284 |
| GO:0051216 | cartilage development | 0.0100263524183424 |
| GO:0048731 | system development | 0.0146727669410031 |
| GO:0005201 | extracellular matrix structural constituent | 0.0146727669410031 |
| GO:0007275 | multicellular organismal development | 0.0146727669410031 |
| GO:0006817 | phosphate transport | 0.0173945241819232 |
| GO:0032502 | developmental process | 0.0201871413154484 |
| GO:0004232 | interstitial collagenase activity | 0.0204368531176428 |
| GO:0002076 | osteoblast development | 0.0258985643784834 |
| GO:0022610 | biological adhesion | 0.0258985643784834 |
| GO:0007155 | cell adhesion | 0.0258985643784834 |
| GO:0044420 | extracellular matrix part | 0.0275598544505392 |
| GO:0006508 | proteolysis | 0.0275598544505392 |
| GO:0045668 | negative regulation of osteoblast differentiation | 0.0290606792893455 |
| GO:0008133 | collagenase activity | 0.0290606792893455 |
| GO:0004720 | protein-lysine 6-oxidase activity | 0.0341414850662139 |
| GO:0008233 | peptidase activity | 0.0347487623026659 |
| GO:0004245 | neprilysin activity | 0.0382477051841511 |
Relative expression of the co-expression cluster over median <br>Analyst:
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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
| Ontology term | p-value | n |
|---|
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
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