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Coexpression cluster:C936

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Full id: C936_CD4_CD14_granulocyte_CD14CD16_CD8_Dendritic_Hair



Phase1 CAGE Peaks

Hg19::chr20:35580040..35580066,-p3@SAMHD1
Hg19::chr20:35580068..35580094,-p1@SAMHD1
Hg19::chr20:35580104..35580133,-p2@SAMHD1
Hg19::chr20:35580152..35580163,-p5@SAMHD1
Hg19::chr20:35580173..35580200,-p4@SAMHD1
Hg19::chr20:35580214..35580223,-p7@SAMHD1
Hg19::chr20:35580240..35580251,-p6@SAMHD1
Hg19::chr7:142960556..142960600,+p1@GSTK1
Hg19::chr9:4985246..4985329,+p1@JAK2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0030288outer membrane-bounded periplasmic space0.0115035799203901
GO:0030313cell envelope0.0115035799203901
GO:0044462external encapsulating structure part0.0115035799203901
GO:0007262STAT protein nuclear translocation0.0115035799203901
GO:0004718Janus kinase activity0.0115035799203901
GO:0042597periplasmic space0.0115035799203901
GO:0030312external encapsulating structure0.0115035799203901
GO:0004716receptor signaling protein tyrosine kinase activity0.0196075728125403
GO:0004602glutathione peroxidase activity0.0196075728125403
GO:0015035protein disulfide oxidoreductase activity0.0196075728125403
GO:0042169SH2 domain binding0.0196075728125403
GO:0007260tyrosine phosphorylation of STAT protein0.0196075728125403
GO:0006749glutathione metabolic process0.0196075728125403
GO:0015036disulfide oxidoreductase activity0.0196746334083543
GO:0000060protein import into nucleus, translocation0.0196746334083543
GO:0007259JAK-STAT cascade0.0280287321429359
GO:0004715non-membrane spanning protein tyrosine kinase activity0.0280287321429359
GO:0018108peptidyl-tyrosine phosphorylation0.0280287321429359
GO:0018212peptidyl-tyrosine modification0.0280287321429359
GO:0004364glutathione transferase activity0.0280287321429359
GO:0007498mesoderm development0.0280287321429359
GO:0045121lipid raft0.0280287321429359
GO:0002376immune system process0.0320820002381753
GO:0004601peroxidase activity0.0359033090866457
GO:0016684oxidoreductase activity, acting on peroxide as acceptor0.0359033090866457
GO:0030099myeloid cell differentiation0.0396633258639042
GO:0016765transferase activity, transferring alkyl or aryl (other than methyl) groups0.0411241581148477
GO:0006790sulfur metabolic process0.0411241581148477
GO:0006606protein import into nucleus0.0418241842302334
GO:0051170nuclear import0.0418241842302334
GO:0042579microbody0.0418241842302334
GO:0005777peroxisome0.0418241842302334
GO:0018193peptidyl-amino acid modification0.0479928798143188
GO:0017038protein import0.0479928798143188
GO:0019904protein domain specific binding0.0485252268225351



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
leukocyte2.55e-34140
nongranular leukocyte3.78e-32119
hematopoietic lineage restricted progenitor cell5.48e-29124
myeloid leukocyte1.13e-2876
macrophage dendritic cell progenitor8.19e-2865
granulocyte monocyte progenitor cell2.13e-2771
monopoietic cell2.15e-2763
monocyte2.15e-2763
monoblast2.15e-2763
promonocyte2.15e-2763
hematopoietic stem cell2.66e-26172
angioblastic mesenchymal cell2.66e-26172
hematopoietic oligopotent progenitor cell3.62e-24165
hematopoietic multipotent progenitor cell3.62e-24165
myeloid lineage restricted progenitor cell5.01e-2470
hematopoietic cell2.18e-23182
CD14-positive, CD16-negative classical monocyte8.61e-2342
classical monocyte9.24e-2245
myeloid cell4.81e-18112
common myeloid progenitor4.81e-18112
mature alpha-beta T cell2.19e-0918
alpha-beta T cell2.19e-0918
immature T cell2.19e-0918
mature T cell2.19e-0918
immature alpha-beta T cell2.19e-0918
mesenchymal cell2.77e-07358
connective tissue cell3.24e-07365
Uber Anatomy
Ontology termp-valuen
hemolymphoid system1.65e-31112
hematopoietic system3.82e-31102
blood island3.82e-31102
bone marrow4.07e-2480
immune system1.05e-22115
adult organism7.41e-20115
bone element1.04e-1986
skeletal element2.19e-17101
skeletal system2.19e-17101
musculoskeletal system7.92e-09167
lateral plate mesoderm2.26e-08216


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467717.47135796467351.14940906869096e-088.6237883423143e-07
CTCF#1066484.764672331622251.10088565904027e-050.000285015858563477
CTCFL#140690817.55242165242163.70770685210878e-103.6914127352468e-08
E2F1#186984.36212374655942.18983367577486e-050.000481279543906252
E2F4#187479.852935800776795.95188909661047e-072.73716136222326e-05
E2F6#187695.017155731697394.96068808485209e-072.32431270925916e-05
HEY1#2346294.040111043105713.4850025352467e-060.000115987947666868
HMGN3#932487.269820198533864.00320733604597e-071.93560634708012e-05
JUN#372579.732200482928266.47658215823223e-072.93834823641883e-05
MXI1#460177.747889044590563.07469224127045e-060.000103720214142779
NANOG#79923722.74593881856541.84595149658852e-091.59991143860754e-07
NRF1#4899912.21027944771091.65394511709215e-101.73604396064308e-08
PAX5#507953.705314183987680.005616557077719420.0253945021273621
PBX3#5090717.04462097857881.36394115359822e-081.00315950803271e-06
POLR2A#543092.147453176558070.001029412892608020.00728887139600606
RFX5#599379.370597310040638.3937256470655e-073.65111333966628e-05
SIN3A#2594284.807897534946791.02597602607548e-050.000268080836095314
TAF1#687293.343046285745291.91655056102793e-050.000433533948544935
TBP#690893.706770687096397.56501052505806e-060.000215928432420481
TCF7L2#693478.376803993551271.80610965338292e-066.77300847718704e-05
TFAP2A#7020814.68323055381771.5325776526732e-091.35415293965767e-07
TFAP2C#702289.608203208764644.42575919806395e-082.89794272656176e-06
THAP1#55145724.39822357999551.13434844000145e-091.04195441271162e-07
ZEB1#693535.629477339181290.01330488236341950.0470379678803415



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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