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Coexpression cluster:C88

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Full id: C88_Melanocyte_melanoma_Macrophage_Mesenchymal_migratory_Dendritic_Monocytederived



Phase1 CAGE Peaks

Hg19::chr10:106240041..106240047,-p1@ENST00000447860
Hg19::chr10:29811685..29811692,-p36@SVIL
Hg19::chr10:4046629..4046639,+p@chr10:4046629..4046639
+
Hg19::chr10:93335091..93335099,-p6@BC044257
Hg19::chr11:109962897..109962926,+p@chr11:109962897..109962926
+
Hg19::chr11:12398061..12398074,+p@chr11:12398061..12398074
+
Hg19::chr11:126225529..126225660,+p1@ST3GAL4
Hg19::chr11:14586167..14586191,+p@chr11:14586167..14586191
+
Hg19::chr11:2920725..2920736,-p5@SLC22A18AS
Hg19::chr11:2920738..2920749,-p7@SLC22A18AS
Hg19::chr11:2920857..2920864,+p13@SLC22A18
Hg19::chr11:61112944..61112955,+p9@DAK
Hg19::chr11:88909137..88909155,-p@chr11:88909137..88909155
-
Hg19::chr12:124850619..124850624,-p@chr12:124850619..124850624
-
Hg19::chr12:132312931..132312971,+p1@MMP17
Hg19::chr12:28947878..28947885,-p@chr12:28947878..28947885
-
Hg19::chr12:56351171..56351183,-p8@PMEL
Hg19::chr12:56364848..56364864,+p12@CDK2
Hg19::chr12:63025600..63025629,+p@chr12:63025600..63025629
+
Hg19::chr12:89817974..89818019,+p@chr12:89817974..89818019
+
Hg19::chr13:49155067..49155077,-p@chr13:49155067..49155077
-
Hg19::chr13:49155365..49155378,+p@chr13:49155365..49155378
+
Hg19::chr13:52459545..52459551,-p@chr13:52459545..52459551
-
Hg19::chr14:93559337..93559385,-p@chr14:93559337..93559385
-
Hg19::chr15:28341225..28341238,-p@chr15:28341225..28341238
-
Hg19::chr15:28344444..28344469,-p1@OCA2
Hg19::chr15:28360857..28360860,-p@chr15:28360857..28360860
-
Hg19::chr15:28413731..28413765,-p@chr15:28413731..28413765
-
Hg19::chr15:42694546..42694554,+p18@CAPN3
Hg19::chr15:42694558..42694570,+p10@CAPN3
Hg19::chr15:42694573..42694641,+p7@CAPN3
Hg19::chr15:42694649..42694650,+p24@CAPN3
Hg19::chr15:42694665..42694671,+p16@CAPN3
Hg19::chr15:42697065..42697078,+p8@CAPN3
Hg19::chr15:56649336..56649342,+p@chr15:56649336..56649342
+
Hg19::chr15:77861183..77861202,+p2@ENST00000560590
p2@ENST00000561123
Hg19::chr15:81474930..81474948,+p9@IL16
Hg19::chr15:93221398..93221407,-p@chr15:93221398..93221407
-
Hg19::chr15:93221436..93221457,-p@chr15:93221436..93221457
-
Hg19::chr16:1521954..1521959,-p@chr16:1521954..1521959
-
Hg19::chr16:27730289..27730294,+p@chr16:27730289..27730294
+
Hg19::chr16:27730402..27730415,+p@chr16:27730402..27730415
+
Hg19::chr16:27771451..27771455,+p@chr16:27771451..27771455
+
Hg19::chr16:68678809..68678833,+p5@CDH3
Hg19::chr16:68678836..68678860,+p4@CDH3
Hg19::chr16:68678879..68678886,+p10@CDH3
Hg19::chr16:68678892..68678897,+p12@CDH3
Hg19::chr16:68678900..68678907,+p11@CDH3
Hg19::chr16:68678922..68678943,+p6@CDH3
Hg19::chr16:68678959..68679004,+p7@CDH3
Hg19::chr16:68680075..68680109,-p@chr16:68680075..68680109
-
Hg19::chr16:84074735..84074743,+p@chr16:84074735..84074743
+
Hg19::chr16:89985263..89985286,+p1@ENST00000540694
Hg19::chr16:89986242..89986250,+p@chr16:89986242..89986250
+
Hg19::chr16:89986251..89986268,+p@chr16:89986251..89986268
+
Hg19::chr17:30850461..30850471,-p@chr17:30850461..30850471
-
Hg19::chr17:505227..505267,-p@chr17:505227..505267
-
Hg19::chr17:75316266..75316279,+p33@SEPT9
Hg19::chr17:75316336..75316406,+p5@SEPT9
Hg19::chr17:77923564..77923575,-p@chr17:77923564..77923575
-
Hg19::chr17:77923585..77923600,-p@chr17:77923585..77923600
-
Hg19::chr17:77924634..77924661,-p2@TBC1D16
Hg19::chr17:77924675..77924686,-p3@TBC1D16
Hg19::chr17:77924692..77924709,-p4@TBC1D16
Hg19::chr17:77925754..77925770,-p@chr17:77925754..77925770
-
Hg19::chr17:77925806..77925817,-p@chr17:77925806..77925817
-
Hg19::chr17:77925869..77925876,-p@chr17:77925869..77925876
-
Hg19::chr18:20715441..20715457,+p1@CABLES1
Hg19::chr18:67872552..67872584,-p@chr18:67872552..67872584
-
Hg19::chr18:67872703..67872710,-p@chr18:67872703..67872710
-
Hg19::chr18:74845949..74845955,-p47@MBP
Hg19::chr19:1168968..1168981,-p@chr19:1168968..1168981
-
Hg19::chr19:15235947..15235958,-p5@ILVBL
Hg19::chr19:15235970..15236010,-p3@ILVBL
Hg19::chr19:19569270..19569277,+p32@GATAD2A
Hg19::chr19:29374467..29374501,+p@chr19:29374467..29374501
+
Hg19::chr19:3544396..3544409,-p@chr19:3544396..3544409
-
Hg19::chr19:3544594..3544603,-p@chr19:3544594..3544603
-
Hg19::chr19:3544629..3544640,-p@chr19:3544629..3544640
-
Hg19::chr19:3546150..3546160,-p@chr19:3546150..3546160
-
Hg19::chr19:3546308..3546322,-p@chr19:3546308..3546322
-
Hg19::chr19:3547305..3547318,-p@chr19:3547305..3547318
-
Hg19::chr19:3547534..3547553,-p@chr19:3547534..3547553
-
Hg19::chr19:3547903..3547940,-p@chr19:3547903..3547940
-
Hg19::chr19:3547999..3548008,-p@chr19:3547999..3548008
-
Hg19::chr19:3551058..3551077,-p@chr19:3551058..3551077
-
Hg19::chr19:3551104..3551146,-p@chr19:3551104..3551146
-
Hg19::chr19:3551160..3551196,-p@chr19:3551160..3551196
-
Hg19::chr19:3553724..3553727,-p@chr19:3553724..3553727
-
Hg19::chr19:3554540..3554542,-p@chr19:3554540..3554542
-
Hg19::chr19:3557499..3557510,-p3@MFSD12
Hg19::chr19:3557570..3557590,-p1@MFSD12
Hg19::chr19:3557606..3557617,-p2@MFSD12
Hg19::chr19:3557773..3557778,-p13@MFSD12
Hg19::chr19:3557800..3557811,-p9@MFSD12
Hg19::chr19:3557823..3557843,-p5@MFSD12
Hg19::chr19:3557867..3557877,-p7@MFSD12
Hg19::chr19:3557918..3557927,-p8@MFSD12
Hg19::chr19:3557930..3557939,-p12@MFSD12
Hg19::chr19:3557974..3557985,-p11@MFSD12
Hg19::chr19:3557989..3557998,-p10@MFSD12
Hg19::chr19:3558028..3558043,-p6@MFSD12
Hg19::chr19:3558051..3558082,-p4@MFSD12
Hg19::chr19:3558086..3558102,-p@chr19:3558086..3558102
-
Hg19::chr19:3572689..3572697,+p22@HMG20B
Hg19::chr19:3572758..3572795,+p7@HMG20B
Hg19::chr19:3572925..3573014,+p1@HMG20B
Hg19::chr19:3573783..3573829,-p@chr19:3573783..3573829
-
Hg19::chr19:3574157..3574180,+p4@HMG20B
Hg19::chr19:3574330..3574393,+p2@HMG20B
Hg19::chr19:3574400..3574430,+p6@HMG20B
Hg19::chr19:3574468..3574478,+p19@HMG20B
Hg19::chr1:1497446..1497455,-p4@AK129493
Hg19::chr1:1497497..1497523,-p1@AK129493
Hg19::chr1:1497528..1497559,-p2@AK129493
Hg19::chr1:1497566..1497576,-p3@AK129493
Hg19::chr1:1535369..1535429,-p2@LOC643988
Hg19::chr1:1535455..1535568,-p1@LOC643988
Hg19::chr1:154401791..154401807,+p11@IL6R
Hg19::chr1:16007955..16007970,+p@chr1:16007955..16007970
+
Hg19::chr1:16007974..16007985,+p@chr1:16007974..16007985
+
Hg19::chr1:16007995..16008026,+p@chr1:16007995..16008026
+
Hg19::chr1:161676969..161676980,+p5@FCRLA
Hg19::chr1:161676983..161676994,+p3@FCRLA
Hg19::chr1:207083151..207083160,-p14@FAIM3
Hg19::chr1:207083172..207083189,-p8@FAIM3
Hg19::chr1:207083199..207083262,-p3@FAIM3
Hg19::chr1:207083310..207083326,-p6@FAIM3
Hg19::chr1:207083343..207083348,-p19@FAIM3
Hg19::chr1:207083660..207083669,-p20@FAIM3
Hg19::chr1:216221933..216221937,-p@chr1:216221933..216221937
-
Hg19::chr1:236035593..236035595,-p@chr1:236035593..236035595
-
Hg19::chr1:236046760..236046770,-p13@LYST
Hg19::chr1:2488970..2488979,+p21@TNFRSF14
Hg19::chr1:2488990..2488993,+p29@TNFRSF14
Hg19::chr1:2489069..2489079,+p20@TNFRSF14
Hg19::chr1:32705788..32705829,-p2@MTMR9LP
Hg19::chr1:64104373..64104382,+p@chr1:64104373..64104382
+
Hg19::chr1:64104401..64104429,+p@chr1:64104401..64104429
+
Hg19::chr20:55091919..55091934,+p1@FAM209A
Hg19::chr20:55091968..55091976,+p6@FAM209A
Hg19::chr21:38568192..38568213,+p@chr21:38568192..38568213
+
Hg19::chr21:38568227..38568233,+p@chr21:38568227..38568233
+
Hg19::chr22:19939035..19939049,+p21@COMT
Hg19::chr22:19939060..19939090,+p10@COMT
Hg19::chr22:20877924..20877934,+p39@MED15
Hg19::chr22:20877995..20878006,+p40@MED15
Hg19::chr22:20878024..20878053,+p16@MED15
Hg19::chr22:20878077..20878083,+p47@MED15
Hg19::chr22:20878094..20878105,+p41@MED15
Hg19::chr22:26899907..26899914,-p@chr22:26899907..26899914
-
Hg19::chr22:47377231..47377232,-p@chr22:47377231..47377232
-
Hg19::chr2:10559858..10559877,+p3@HPCAL1
Hg19::chr2:11752379..11752396,+p5@GREB1
Hg19::chr2:128400745..128400763,-p23@LIMS2
Hg19::chr2:128400774..128400781,-p51@LIMS2
Hg19::chr2:128400788..128400798,-p44@LIMS2
Hg19::chr2:128400821..128400830,-p39@LIMS2
Hg19::chr2:163099546..163099567,-p4@FAP
Hg19::chr2:202285267..202285291,-p3@TRAK2
Hg19::chr2:232086654..232086692,+p@chr2:232086654..232086692
+
Hg19::chr2:238395042..238395061,+p2@MLPH
Hg19::chr2:240116933..240116969,-p1@MGC16025
Hg19::chr2:242350325..242350332,+p8@FARP2
Hg19::chr2:242350337..242350369,+p3@FARP2
Hg19::chr2:65216118..65216131,+p7@SLC1A4
Hg19::chr2:65216141..65216162,+p9@SLC1A4
Hg19::chr2:65216462..65216567,+p1@SLC1A4
Hg19::chr3:132136879..132136891,+p@chr3:132136879..132136891
+
Hg19::chr3:48601207..48601222,-p1@UCN2
Hg19::chr3:69951861..69951868,+p@chr3:69951861..69951868
+
Hg19::chr3:69987438..69987455,+p@chr3:69987438..69987455
+
Hg19::chr5:159894757..159894771,+p4@uc003lyl.3
Hg19::chr5:159894797..159894808,+p9@uc003lyl.3
Hg19::chr5:159894810..159894819,+p12@uc003lyl.3
Hg19::chr5:159894828..159894839,+p6@uc003lyl.3
Hg19::chr5:159894844..159894853,+p10@uc003lyl.3
Hg19::chr5:159894864..159894881,+p5@uc003lyl.3
Hg19::chr5:159894905..159894938,+p2@uc003lyl.3
Hg19::chr5:159894950..159894958,+p8@uc003lyl.3
Hg19::chr5:159895000..159895003,+p7@uc003lyl.3
Hg19::chr5:159895082..159895093,+p11@uc003lyl.3
Hg19::chr5:159896855..159896863,+p@chr5:159896855..159896863
+
Hg19::chr5:159904569..159904581,-p@chr5:159904569..159904581
-
Hg19::chr5:39462314..39462332,-p15@DAB2
Hg19::chr5:79421543..79421571,-p@chr5:79421543..79421571
-
Hg19::chr6:10435032..10435061,-p1@LINC00518
Hg19::chr6:132834443..132834454,-p6@STX7
Hg19::chr6:16238880..16238915,+p2@GMPR
Hg19::chr6:9251842..9251865,+p@chr6:9251842..9251865
+
Hg19::chr7:150775279..150775302,-p@chr7:150775279..150775302
-
Hg19::chr7:20685431..20685438,+p@chr7:20685431..20685438
+
Hg19::chr7:2692208..2692218,+p51@TTYH3
Hg19::chr7:2692417..2692437,+p3@TTYH3
Hg19::chr7:2692544..2692555,+p17@TTYH3
Hg19::chr7:2701678..2701748,+p7@TTYH3
Hg19::chr7:2701975..2702006,+p18@TTYH3
Hg19::chr7:2702100..2702127,+p20@TTYH3
Hg19::chr7:4008614..4008625,-p@chr7:4008614..4008625
-
Hg19::chr7:43832250..43832263,+p@chr7:43832250..43832263
+
Hg19::chr7:47443023..47443044,-p16@TNS3
Hg19::chr8:12668962..12668969,-p2@ENST00000534827
Hg19::chr8:12669036..12669054,-p1@ENST00000534827
Hg19::chr8:20111065..20111086,-p@chr8:20111065..20111086
-
Hg19::chr8:20111535..20111554,-p@chr8:20111535..20111554
-
Hg19::chr8:29605604..29605613,-p4@C8orf75
Hg19::chr8:29605633..29605652,-p2@C8orf75
Hg19::chr8:41467069..41467095,+p@chr8:41467069..41467095
+
Hg19::chr8:72870195..72870205,+p@chr8:72870195..72870205
+
Hg19::chr9:12694022..12694033,+p15@TYRP1
Hg19::chr9:12709145..12709150,+p@chr9:12709145..12709150
+
Hg19::chr9:134406030..134406042,-p@chr9:134406030..134406042
-
Hg19::chr9:82185685..82185693,+p@chr9:82185685..82185693
+
Hg19::chrX:54522195..54522218,-p5@FGD1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005886plasma membrane0.0034475627203576
GO:0045009chitosome0.00438051250148185
GO:0033162melanosome membrane0.00438051250148185
GO:0005737cytoplasm0.0147934230677054
GO:0048770pigment granule0.0147934230677054
GO:0042470melanosome0.0147934230677054
GO:0044459plasma membrane part0.0314164411585982
GO:0046148pigment biosynthetic process0.0389661244552435
GO:0044425membrane part0.0389661244552435
GO:0005515protein binding0.0389661244552435
GO:0030027lamellipodium0.0389661244552435
GO:0035173histone kinase activity0.0389661244552435
GO:0005395eye pigment precursor transporter activity0.0389661244552435
GO:0015173aromatic amino acid transmembrane transporter activity0.0389661244552435
GO:0005302L-tyrosine transmembrane transporter activity0.0389661244552435
GO:0005896interleukin-6 receptor complex0.0389661244552435
GO:0016206catechol O-methyltransferase activity0.0389661244552435
GO:0042440pigment metabolic process0.0389661244552435
GO:0016020membrane0.0389661244552435
GO:0031410cytoplasmic vesicle0.0441059691015092
GO:0031982vesicle0.0441059691015092
GO:0019748secondary metabolic process0.0441059691015092
GO:0008509anion transmembrane transporter activity0.0441059691015092
GO:0019981interleukin-6 binding0.0441059691015092
GO:0015746citrate transport0.0441059691015092
GO:0051302regulation of cell division0.0441059691015092
GO:0006842tricarboxylic acid transport0.0441059691015092
GO:0015137citrate transmembrane transporter activity0.0441059691015092
GO:0043209myelin sheath0.0441059691015092
GO:0004915interleukin-6 receptor activity0.0441059691015092
GO:0015105arsenite transmembrane transporter activity0.0441059691015092
GO:0004371glycerone kinase activity0.0441059691015092
GO:0015142tricarboxylic acid transmembrane transporter activity0.0441059691015092
GO:0015171amino acid transmembrane transporter activity0.0481266501877381



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
non-terminally differentiated cell8.82e-09180
pigment cell7.17e-0714
Uber Anatomy
Ontology termp-valuen
multi-cellular organism2.50e-17659
organ6.71e-17511
anatomical system1.17e-14625
anatomical group2.61e-14626
embryo1.28e-12612
neural tube1.43e-1157
neural rod1.43e-1157
future spinal cord1.43e-1157
neural keel1.43e-1157
embryonic structure1.83e-11605
developing anatomical structure1.83e-11605
anatomical cluster2.40e-11286
germ layer2.74e-11604
embryonic tissue2.74e-11604
presumptive structure2.74e-11604
epiblast (generic)2.74e-11604
organ part4.65e-11219
organism subdivision5.03e-11365
neural plate1.81e-1086
presumptive neural plate1.81e-1086
epithelium2.97e-10309
gray matter3.23e-1034
brain grey matter3.23e-1034
telencephalon3.32e-1034
cell layer8.24e-10312
regional part of telencephalon9.36e-1033
regional part of brain1.10e-0959
neurectoderm1.26e-0990
cerebral hemisphere3.35e-0932
anterior neural tube3.99e-0942
regional part of forebrain4.23e-0941
forebrain4.23e-0941
future forebrain4.23e-0941
tube4.97e-09194
pre-chordal neural plate9.24e-0961
anatomical conduit1.55e-08241
adult organism3.54e-08115
central nervous system4.19e-0882
brain4.58e-0869
future brain4.58e-0869
regional part of nervous system1.88e-0794
nervous system1.88e-0794
head2.46e-07123
regional part of cerebral cortex2.94e-0722
multi-tissue structure3.91e-07347
larynx4.31e-079
cerebral cortex5.41e-0725
pallium5.41e-0725


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335151.988513208196760.009409567929911350.0355018194802215
BHLHE40#8553112.306495088863330.009109750074354190.0344714923194013
BRF2#55290315.06414366442080.001104269212249570.00767579183082412
GATA2#2624271.608005405635320.01001663553595090.0375575284964162
PRDM1#639127.392390043595931.19925028668985e-076.91216891234003e-06
STAT1#6772222.12871460251580.000754559132250010.00593414165760985



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data