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Coexpression cluster:C3373

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Full id: C3373_mesenchymal_Fibroblast_normal_Smooth_mucinous_Preadipocyte_serous



Phase1 CAGE Peaks

Hg19::chr13:44794616..44794621,+p@chr13:44794616..44794621
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Hg19::chr8:49194425..49194429,+p@chr8:49194425..49194429
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Hg19::chr9:118454273..118454278,+p@chr9:118454273..118454278
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
female gonad3.67e-1713
right ovary8.71e-135
systemic artery2.55e-1233
systemic arterial system2.55e-1233
artery1.27e-1142
arterial blood vessel1.27e-1142
arterial system1.27e-1142
dermomyotome1.70e-1170
left ovary1.43e-104
splanchnic layer of lateral plate mesoderm1.92e-1084
vessel6.14e-1069
multilaminar epithelium8.12e-1082
somite8.33e-1083
paraxial mesoderm8.33e-1083
presomitic mesoderm8.33e-1083
presumptive segmental plate8.33e-1083
trunk paraxial mesoderm8.33e-1083
presumptive paraxial mesoderm8.33e-1083
gonad1.07e-0921
indifferent external genitalia1.07e-0921
indifferent gonad1.07e-0921
gonad primordium1.07e-0921
skeletal muscle tissue2.44e-0961
striated muscle tissue2.44e-0961
myotome2.44e-0961
external genitalia3.76e-0922
muscle tissue6.93e-0963
musculature6.93e-0963
musculature of body6.93e-0963
blood vessel8.46e-0960
epithelial tube open at both ends8.46e-0960
blood vasculature8.46e-0960
vascular cord8.46e-0960
cardiovascular system1.03e-08110
epithelial tube2.21e-08118
circulatory system2.67e-08113
blood vessel smooth muscle3.27e-0810
arterial system smooth muscle3.27e-0810
artery smooth muscle tissue3.27e-0810
aorta smooth muscle tissue3.27e-0810
vasculature5.49e-0879
vascular system5.49e-0879
female reproductive organ8.40e-0837
female reproductive system8.40e-0837
female organism9.57e-0741
Disease
Ontology termp-valuen
ovarian cancer1.41e-2714
female reproductive organ cancer1.10e-1627
reproductive organ cancer3.04e-1529


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.