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Coexpression cluster:C2986

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Full id: C2986_Alveolar_large_breast_chronic_anaplastic_bronchial_skeletal



Phase1 CAGE Peaks

Hg19::chr10:127356632..127356638,-p1@ALDOAP2
Hg19::chr16:30075463..30075519,+p4@ALDOA
Hg19::chr16:30075523..30075542,+p3@ALDOA


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004332fructose-bisphosphate aldolase activity1.50425087954398e-06
GO:0016832aldehyde-lyase activity2.44440767925897e-06
GO:0016830carbon-carbon lyase activity5.94716329876854e-05
GO:0006096glycolysis8.11892550611016e-05
GO:0006007glucose catabolic process8.11892550611016e-05
GO:0019320hexose catabolic process8.11892550611016e-05
GO:0046365monosaccharide catabolic process8.11892550611016e-05
GO:0046164alcohol catabolic process8.11892550611016e-05
GO:0044275cellular carbohydrate catabolic process8.9551766647138e-05
GO:0016052carbohydrate catabolic process8.9551766647138e-05
GO:0006006glucose metabolic process8.9551766647138e-05
GO:0019318hexose metabolic process0.000147750437793577
GO:0005996monosaccharide metabolic process0.000147750437793577
GO:0016829lyase activity0.000147750437793577
GO:0006066alcohol metabolic process0.000353821296167024
GO:0044262cellular carbohydrate metabolic process0.0004121916026179
GO:0044265cellular macromolecule catabolic process0.000431375541618472
GO:0009057macromolecule catabolic process0.000582001828394994
GO:0005975carbohydrate metabolic process0.000877934536547566
GO:0044248cellular catabolic process0.000877934536547566
GO:0009056catabolic process0.00120974004662755
GO:0006000fructose metabolic process0.00190737057953607
GO:0006941striated muscle contraction0.00293436601581802
GO:0006936muscle contraction0.0120161386848327
GO:0003012muscle system process0.0120161386848327



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
segment of respiratory tract7.06e-0846
artery6.66e-0742
arterial blood vessel6.66e-0742
arterial system6.66e-0742
Disease
Ontology termp-valuen
hematologic cancer2.24e-2051
immune system cancer2.24e-2051
leukemia6.62e-1739
myeloid leukemia7.19e-1331
organ system cancer3.17e-07137


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SMC3#9126210.02995522995520.0126656379767470.0457015811447444
TRIM28#10155212.39368336350830.008368344129438470.0328885938336127



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.