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Coexpression cluster:C2299

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Full id: C2299_Mesenchymal_CD14_CD4_NK_granulocyte_Basophils_Anulus



Phase1 CAGE Peaks

Hg19::chr14:52780943..52780957,+p2@PTGER2
Hg19::chr14:52780998..52781056,+p1@PTGER2
Hg19::chr14:52782140..52782164,-p@chr14:52782140..52782164
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Hg19::chr14:52782184..52782227,-p@chr14:52782184..52782227
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
myeloid leukocyte9.79e-2776
CD14-positive, CD16-negative classical monocyte1.02e-2642
connective tissue cell8.17e-25365
granulocyte monocyte progenitor cell1.13e-2371
myeloid lineage restricted progenitor cell1.86e-2370
classical monocyte1.36e-2245
multi fate stem cell2.64e-22430
mesenchymal cell3.26e-22358
monopoietic cell4.03e-2263
monocyte4.03e-2263
monoblast4.03e-2263
promonocyte4.03e-2263
macrophage dendritic cell progenitor8.74e-2165
stem cell1.46e-20444
somatic stem cell2.27e-20436
leukocyte3.91e-19140
nongranular leukocyte9.82e-18119
hematopoietic lineage restricted progenitor cell1.10e-17124
motile cell2.88e-16390
myeloid cell2.06e-13112
common myeloid progenitor2.06e-13112
hematopoietic stem cell2.13e-13172
angioblastic mesenchymal cell2.13e-13172
hematopoietic cell1.72e-12182
hematopoietic oligopotent progenitor cell2.84e-12165
hematopoietic multipotent progenitor cell2.84e-12165
mature alpha-beta T cell1.24e-1018
alpha-beta T cell1.24e-1018
immature T cell1.24e-1018
mature T cell1.24e-1018
immature alpha-beta T cell1.24e-1018
CD8-positive, alpha-beta T cell1.61e-0711
intermediate monocyte2.12e-079
CD14-positive, CD16-positive monocyte2.12e-079
somatic cell2.92e-07591
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.29e-29102
blood island1.29e-29102
hemolymphoid system1.03e-25112
bone marrow6.37e-2580
connective tissue5.76e-24375
skeletal element1.59e-22101
skeletal system1.59e-22101
bone element2.53e-2286
musculoskeletal system4.03e-22167
immune system1.27e-18115
lateral plate mesoderm5.85e-11216
mesoderm1.80e-08448
mesoderm-derived structure1.80e-08448
presumptive mesoderm1.80e-08448


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.