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Coexpression cluster:C2211

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Full id: C2211_Mast_CD19_CD34_Dendritic_immature_Peripheral_CD14



Phase1 CAGE Peaks

Hg19::chr12:52400719..52400736,+p1@GRASP
Hg19::chr12:52401600..52401619,+p@chr12:52401600..52401619
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Hg19::chr18:77155942..77155951,+p3@NFATC1
Hg19::chr19:39898400..39898420,+p@chr19:39898400..39898420
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005528FK506 binding0.00968359077495344
GO:0005527macrolide binding0.00968359077495344
GO:0008144drug binding0.0184414052499597



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
CD14-positive, CD16-negative classical monocyte5.10e-2342
leukocyte1.13e-21140
classical monocyte2.57e-1945
myeloid leukocyte8.46e-1776
granulocyte monocyte progenitor cell1.12e-1471
hematopoietic lineage restricted progenitor cell8.33e-14124
nongranular leukocyte1.82e-13119
hematopoietic stem cell5.18e-13172
angioblastic mesenchymal cell5.18e-13172
macrophage dendritic cell progenitor2.42e-1265
hematopoietic cell3.11e-12182
myeloid lineage restricted progenitor cell7.26e-1270
monopoietic cell2.40e-1163
monocyte2.40e-1163
monoblast2.40e-1163
promonocyte2.40e-1163
hematopoietic oligopotent progenitor cell7.04e-11165
hematopoietic multipotent progenitor cell7.04e-11165
myeloid cell7.82e-09112
common myeloid progenitor7.82e-09112
endothelial cell3.05e-0835
endothelial cell of vascular tree1.67e-0724
intermediate monocyte9.11e-079
CD14-positive, CD16-positive monocyte9.11e-079
Uber Anatomy
Ontology termp-valuen
adult organism6.98e-22115
hemolymphoid system1.04e-12112
lateral plate mesoderm2.39e-12216
hematopoietic system3.19e-11102
blood island3.19e-11102
bone marrow3.59e-1080
immune system3.62e-10115
bone element1.78e-0986
neural tube2.00e-0757
neural rod2.00e-0757
future spinal cord2.00e-0757
neural keel2.00e-0757
regional part of brain8.30e-0759


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.