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Coexpression cluster:C280

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Full id: C280_Mast_Natural_CD19_CD8_Eosinophils_CD34_CD4



Phase1 CAGE Peaks

Hg19::chr10:3827417..3827428,-p3@KLF6
Hg19::chr11:62323018..62323031,-p@chr11:62323018..62323031
-
Hg19::chr11:65657918..65657945,-p@chr11:65657918..65657945
-
Hg19::chr11:66610757..66610775,-p3@CU688443
Hg19::chr12:25539082..25539099,-p@chr12:25539082..25539099
-
Hg19::chr12:9913489..9913506,-p1@CD69
Hg19::chr14:105947382..105947418,+p@chr14:105947382..105947418
+
Hg19::chr14:105947980..105947997,-p@chr14:105947980..105947997
-
Hg19::chr14:60715694..60715716,-p1@ENST00000529171
Hg19::chr14:75725656..75725708,-p@chr14:75725656..75725708
-
Hg19::chr14:75761343..75761358,+p@chr14:75761343..75761358
+
Hg19::chr17:17586443..17586462,-p@chr17:17586443..17586462
-
Hg19::chr17:17739693..17739737,+p@chr17:17739693..17739737
+
Hg19::chr17:38478879..38478895,-p@chr17:38478879..38478895
-
Hg19::chr17:62972061..62972090,-p7@AMZ2P1
Hg19::chr19:14117737..14117757,+p@chr19:14117737..14117757
+
Hg19::chr19:39892410..39892428,+p@chr19:39892410..39892428
+
Hg19::chr19:39892441..39892455,+p@chr19:39892441..39892455
+
Hg19::chr19:45954222..45954237,+p@chr19:45954222..45954237
+
Hg19::chr19:45954249..45954276,+p@chr19:45954249..45954276
+
Hg19::chr19:45954279..45954294,+p@chr19:45954279..45954294
+
Hg19::chr19:45972701..45972774,+p2@FOSB
Hg19::chr19:50554282..50554297,-p@chr19:50554282..50554297
-
Hg19::chr19:58609835..58609860,+p@chr19:58609835..58609860
+
Hg19::chr1:150207241..150207263,+p@chr1:150207241..150207263
+
Hg19::chr1:150584212..150584225,+p@chr1:150584212..150584225
+
Hg19::chr1:156076042..156076062,-p@chr1:156076042..156076062
-
Hg19::chr1:171455188..171455201,-p3@BC007549
Hg19::chr1:19923143..19923206,-p1@ENST00000416470
Hg19::chr1:245132972..245133020,+p2@EFCAB2
Hg19::chr1:245133062..245133098,+p3@EFCAB2
Hg19::chr20:34384518..34384529,-p@chr20:34384518..34384529
-
Hg19::chr21:44847380..44847401,+p@chr21:44847380..44847401
+
Hg19::chr22:42078575..42078594,+p@chr22:42078575..42078594
+
Hg19::chr2:157189859..157189868,+p@chr2:157189859..157189868
+
Hg19::chr2:201729344..201729359,-p3@CLK1
Hg19::chr2:24149009..24149030,+p@chr2:24149009..24149030
+
Hg19::chr2:25195035..25195063,+p2@DNAJC27-AS1
Hg19::chr3:20227985..20227998,+p@chr3:20227985..20227998
+
Hg19::chr6:116575441..116575452,+p4@uc003pwo.1
Hg19::chr6:157342586..157342600,-p@chr6:157342586..157342600
-
Hg19::chr6:16129308..16129327,+p1@MYLIP
Hg19::chr8:101964446..101964498,+p@chr8:101964446..101964498
+
Hg19::chr9:3525727..3525828,-p2@RFX3
Hg19::chr9:3526503..3526519,+p2@ENST00000423112
Hg19::chr9:91933575..91933588,-p@chr9:91933575..91933588
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
6.17544927282532e-060.003909059389698423162TNF alpha/NF-kB down reg. targets (Netpath):NetPath_9



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell7.05e-45172
angioblastic mesenchymal cell7.05e-45172
leukocyte2.04e-44140
hematopoietic cell4.70e-41182
hematopoietic oligopotent progenitor cell4.78e-41165
hematopoietic multipotent progenitor cell4.78e-41165
hematopoietic lineage restricted progenitor cell4.02e-35124
nongranular leukocyte9.96e-34119
CD14-positive, CD16-negative classical monocyte1.49e-2342
classical monocyte1.27e-2145
lymphocyte2.46e-2053
common lymphoid progenitor2.46e-2053
myeloid cell3.71e-20112
common myeloid progenitor3.71e-20112
lymphoid lineage restricted progenitor cell4.25e-2052
myeloid leukocyte1.36e-1876
granulocyte monocyte progenitor cell6.71e-1671
myeloid lineage restricted progenitor cell2.61e-1470
macrophage dendritic cell progenitor2.63e-1365
monopoietic cell2.13e-1263
monocyte2.13e-1263
monoblast2.13e-1263
promonocyte2.13e-1263
T cell9.75e-1125
pro-T cell9.75e-1125
mature alpha-beta T cell1.34e-1018
alpha-beta T cell1.34e-1018
immature T cell1.34e-1018
mature T cell1.34e-1018
immature alpha-beta T cell1.34e-1018
lymphocyte of B lineage9.11e-0924
pro-B cell9.11e-0924
B cell1.98e-0714
CD8-positive, alpha-beta T cell9.13e-0711
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.44e-20102
blood island1.44e-20102
hemolymphoid system1.15e-17112
bone marrow2.94e-1480
bone element4.73e-1486
adult organism3.73e-10115
immune system6.52e-10115
skeletal element6.35e-09101
skeletal system6.35e-09101


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#5333574.317090994027160.001078084552234020.00761182210321585
BCL3#60264.506143843965870.002035986867553540.011824960096787
BRCA1#672146.143026717502882.82527442542498e-081.92603678666423e-06
CCNT2#905283.856818351194655.0761257913336e-126.61854558702984e-10
CEBPB#1051162.772573087243418.85618406965618e-050.00129760242431372
CHD2#1106184.047661109002251.04787550155742e-076.1241784838923e-06
E2F1#1869282.98710647862222.49079647788142e-092.11149588760923e-07
E2F4#1874143.855496617695277.64706218551962e-060.000217972578491671
E2F6#1876293.162989483026612.2426729101714e-102.30307292099696e-08
EBF1#1879142.710663822868830.0003629593213753860.0036243530514508
EGR1#1958333.57847630714645.64412029062498e-149.12486500050436e-12
ELF1#1997292.684453060987361.25513880516566e-089.32328888141514e-07
ELK4#200582.823596810168350.00656760806232610.0280698321501586
EP300#2033223.239711260367621.08793059315116e-076.34053477779654e-06
ESR1#2099106.688826803511841.82003034097748e-066.75487380175364e-05
FOS#2353132.54290041338320.001148129041516760.00785313045824668
FOSL2#2355124.416574070755221.05147803526648e-050.000273172424192028
FOXA1#3169122.89080515201360.0006072653966565240.00506890910816901
GABPB1#2553162.45832481258510.0003656422386977120.00364939886920397
GATA1#2623113.242682382213150.0004130141450732380.00393386085702726
GATA3#262574.144687271748740.001363545100422790.00897506061278478
GTF2B#295953.472155427643940.01418348431271470.0497584453522206
GTF2F1#2962154.154237242420971.27657572022556e-065.10625398868776e-05
HDAC2#306692.624795263687750.006228743151318980.0274888529888275
HEY1#23462332.898340530923662.79057128948827e-113.26365593396266e-09
HMGN3#9324223.911479345950283.33656122442016e-092.75468077246812e-07
HSF1#3297310.71460869565220.002809367600468750.0153801720828933
IRF1#3659203.320505979810393.90366729260953e-071.8980219197991e-05
JUN#3725143.808252362884978.80966587461091e-060.000237744882242504
JUND#3727223.345274059155716.07520271249101e-083.7677440385383e-06
MAX#4149192.665185971111642.38683755310401e-050.000520415296886493
MEF2A#4205104.074615415140010.0001287480981055410.00171116347900797
MEF2C#420854.490364618763480.004985557797800120.0232740332042038
MXI1#4601255.41389762432578.99596347527704e-141.41495395993141e-11
MYC#4609262.951724536127052.08087698330037e-081.48041356443397e-06
NFKB1#4790293.459866071774372.34035757418545e-112.787053645272e-09
NFYA#480093.605004919532060.000718040202295040.00573679625822304
NFYB#4801114.00777664758486.43485465705113e-050.00104696959889042
NR3C1#2908113.580505579193550.0001753344960213330.00213249789565297
NRF1#4899143.716172005825061.1653236447232e-050.000296552719618046
PAX5#5079273.914744985691331.19828201832722e-111.48984971085805e-09
PBX3#509094.287622047406460.0002024221915653560.00240427286078633
POLR2A#5430442.05408564714257.59234119205233e-131.08919851889664e-10
POU2F2#5452265.146939684810996.7909221724601e-141.08446042931125e-11
PRDM1#63938.597671028964830.005186038749451220.0240369547310139
RDBP#7936310.01989591239290.003389725380753140.0173004705585925
REST#5978142.936965261430270.0001564490576728030.00197287891020163
RFX5#5993236.023955413597551.67009377927883e-132.55004275166816e-11
RXRA#6256104.364047204159417.30215440325001e-050.0011468115845429
SIN3A#25942313.645117968071074.95966755376827e-137.23439552581012e-11
SMARCB1#659883.174385353244770.003254179262548840.0168566227557454
SMARCC1#659954.746017317351250.003950573519571360.0189654768012187
SP1#6667303.716335681396241.06920996712667e-121.50090349135406e-10
SP2#666863.411330064414520.007867546284875830.0323024989757498
SREBF1#672099.196796629660754.7861079389151e-072.25770698749934e-05
SRF#6722123.599263894478567.89027074196385e-050.00120899645836262
TAF1#6872423.052346608723963.92905562788341e-188.7307795897982e-16
TAF7#6879194.72235475420773.1362546328173e-092.61828375377143e-07
TBP#6908383.062114915427455.39932691943666e-159.47731603595034e-13
TCF12#6938153.467760294191221.18181286891873e-050.000299000373587701
TCF7L2#6934173.980282642898583.48856912736139e-071.72429091856364e-05
TFAP2C#7022112.584815537140490.002652407479740160.0146398258522663
USF1#7391172.350988863315980.0003775083617368490.00374457173439403
YY1#7528293.09617286403833.81833363335084e-103.78351941492911e-08
ZBTB33#1000964.130181525649720.003137552918294680.0164739273658327
ZBTB7A#51341152.39736173082910.000786133556522270.00615880297874348



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

"{{{coexpression_dpi_cluster_scores_median}}}" is not a number.

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