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Coexpression cluster:C375

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Full id: C375_optic_Cardiac_occipital_hippocampus_amygdala_heart_vagina



Phase1 CAGE Peaks

Hg19::chr10:23728870..23728914,-p@chr10:23728870..23728914
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Hg19::chr14:64194979..64194990,-p5@SGPP1
Hg19::chr15:28878244..28878278,+p3@HERC2P9
Hg19::chr15:59203645..59203660,+p1@ENST00000460205
Hg19::chr18:74691000..74691005,-p@chr18:74691000..74691005
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Hg19::chr18:77772838..77772849,+p1@ENST00000496399
Hg19::chr19:22877694..22877711,-p@chr19:22877694..22877711
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Hg19::chr19:24186022..24186033,-p@chr19:24186022..24186033
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Hg19::chr19:36369966..36369979,+p@chr19:36369966..36369979
+
Hg19::chr1:6663197..6663214,+p@chr1:6663197..6663214
+
Hg19::chr20:3052264..3052270,+p1@OXT
Hg19::chr20:3065362..3065375,-p1@AVP
Hg19::chr20:56423415..56423424,+p@chr20:56423415..56423424
+
Hg19::chr2:133013437..133013446,-p@chr2:133013437..133013446
-
Hg19::chr4:41216423..41216432,+p@chr4:41216423..41216432
+
Hg19::chr4:79860452..79860464,+p@chr4:79860452..79860464
+
Hg19::chr5:149681987..149681999,+p@chr5:149681987..149681999
+
Hg19::chr6:3692134..3692138,-p@chr6:3692134..3692138
-
Hg19::chr7:100231306..100231312,+p@chr7:100231306..100231312
+
Hg19::chr7:143208421..143208425,-p1@OR10AC1P
Hg19::chr7:148638615..148638633,+p1@RNY5
Hg19::chr7:22158177..22158186,-p@chr7:22158177..22158186
-
Hg19::chr8:22411813..22411825,+p55@SORBS3
Hg19::chr8:56755058..56755080,-p@chr8:56755058..56755080
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Hg19::chr9:102693980..102693990,+p@chr9:102693980..102693990
+
Hg19::chr9:139740358..139740365,+p@chr9:139740358..139740365
+
Hg19::chr9:79186715..79186726,+p@chr9:79186715..79186726
+
Hg19::chrX:39548044..39548047,+p@chrX:39548044..39548047
+
Hg19::chrY:10035184..10035200,+p@chrY:10035184..10035200
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0031895V1B vasopressin receptor binding6.82805122742316e-07
GO:0031855oxytocin receptor binding6.82805122742316e-07
GO:0050891body fluid osmoregulation6.82805122742316e-07
GO:0031893vasopressin receptor binding1.02416748363524e-06
GO:0005185neurohypophyseal hormone activity1.02416748363524e-06
GO:0031894V1A vasopressin receptor binding1.02416748363524e-06
GO:0018987osmoregulation8.19173195646287e-06
GO:0005184neuropeptide hormone activity0.000135030968425998
GO:0001664G-protein-coupled receptor binding0.00121415974217814
GO:0050878regulation of body fluid levels0.00157986801149862
GO:0042392sphingosine-1-phosphate phosphatase activity0.00210868843860719
GO:0030816positive regulation of cAMP metabolic process0.00226678572039262
GO:0006670sphingosine metabolic process0.00226678572039262
GO:0006667sphinganine metabolic process0.00226678572039262
GO:0030804positive regulation of cyclic nucleotide biosynthetic process0.00226678572039262
GO:0045981positive regulation of nucleotide metabolic process0.00226678572039262
GO:0030819positive regulation of cAMP biosynthetic process0.00226678572039262
GO:0006668sphinganine-1-phosphate metabolic process0.00226678572039262
GO:0030810positive regulation of nucleotide biosynthetic process0.00226678572039262
GO:0030801positive regulation of cyclic nucleotide metabolic process0.00226678572039262
GO:0005179hormone activity0.00226678572039262
GO:0051496positive regulation of stress fiber formation0.00289919055618893
GO:0051495positive regulation of cytoskeleton organization and biogenesis0.00289919055618893
GO:0032233positive regulation of actin filament bundle formation0.00289919055618893
GO:0048878chemical homeostasis0.00368039417526195
GO:0030817regulation of cAMP biosynthetic process0.0039985303853693
GO:0003091renal water homeostasis0.0039985303853693
GO:0030146diuresis0.0039985303853693
GO:0017166vinculin binding0.0039985303853693
GO:0030802regulation of cyclic nucleotide biosynthetic process0.00409243273910375
GO:0051492regulation of stress fiber formation0.00409243273910375
GO:0030808regulation of nucleotide biosynthetic process0.00409243273910375
GO:0032231regulation of actin filament bundle formation0.00409243273910375
GO:0030814regulation of cAMP metabolic process0.00409243273910375
GO:0030799regulation of cyclic nucleotide metabolic process0.00438718911543101
GO:0043149stress fiber formation0.00438718911543101
GO:0030104water homeostasis0.00438718911543101
GO:0007567parturition0.00475659573642449
GO:0043410positive regulation of MAPKKK cascade0.00475659573642449
GO:0003014renal system process0.00521716056497323
GO:0042592homeostatic process0.00552056104825354
GO:0006140regulation of nucleotide metabolic process0.00552056104825354
GO:0006833water transport0.00579633313918826
GO:0042044fluid transport0.00579633313918826
GO:0051130positive regulation of cellular component organization and biogenesis0.00721225905871929
GO:0043408regulation of MAPKKK cascade0.00755909920924628
GO:0042310vasoconstriction0.00789113665704299
GO:0007589fluid secretion0.00869181253526654
GO:0051017actin filament bundle formation0.00880731442979931
GO:0006171cAMP biosynthetic process0.00880731442979931
GO:0046058cAMP metabolic process0.00999665889986511
GO:0005925focal adhesion0.015011611682781
GO:0000267cell fraction0.015011611682781
GO:0046519sphingoid metabolic process0.015011611682781
GO:0005924cell-substrate adherens junction0.015435742176374
GO:0065008regulation of biological quality0.015435742176374
GO:0048522positive regulation of cellular process0.015435742176374
GO:0009190cyclic nucleotide biosynthetic process0.015435742176374
GO:0030055cell-matrix junction0.015435742176374
GO:0007015actin filament organization0.015435742176374
GO:0007588excretion0.015435742176374
GO:0035150regulation of tube size0.015435742176374
GO:0050880regulation of blood vessel size0.015435742176374
GO:0003018vascular process in circulatory system0.0155556468794977
GO:0005102receptor binding0.0162484472590287
GO:0048518positive regulation of biological process0.0167667441072256
GO:0009187cyclic nucleotide metabolic process0.0172727118713187
GO:0005912adherens junction0.0183769505943518
GO:0051493regulation of cytoskeleton organization and biogenesis0.0185114408611819
GO:0033043regulation of organelle organization and biogenesis0.0185114408611819
GO:0006950response to stress0.020506881207144
GO:0006665sphingolipid metabolic process0.0218422042088823
GO:0009891positive regulation of biosynthetic process0.0221746544257607
GO:0035239tube morphogenesis0.0258463519980026
GO:0005200structural constituent of cytoskeleton0.0258463519980026
GO:0016323basolateral plasma membrane0.0258463519980026
GO:0051128regulation of cellular component organization and biogenesis0.0299926897886429
GO:0031589cell-substrate adhesion0.0304923716384611
GO:0007165signal transduction0.0306487966665124
GO:0035295tube development0.033750160244109
GO:0000122negative regulation of transcription from RNA polymerase II promoter0.0361665252615426
GO:0007154cell communication0.0369427395620263
GO:0000165MAPKKK cascade0.0416447144289407
GO:0009967positive regulation of signal transduction0.0419663592318712
GO:0008015blood circulation0.0428525175398149
GO:0003013circulatory system process0.0428525175398149



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism8.68e-42115
neural tube1.12e-1557
neural rod1.12e-1557
future spinal cord1.12e-1557
neural keel1.12e-1557
anterior neural tube7.66e-1342
regional part of forebrain2.24e-1241
forebrain2.24e-1241
future forebrain2.24e-1241
regional part of brain3.56e-1259
gray matter5.59e-1134
brain grey matter5.59e-1134
neural plate1.22e-1086
presumptive neural plate1.22e-1086
regional part of telencephalon4.01e-1033
neurectoderm5.66e-1090
telencephalon6.16e-1034
tube2.67e-09194
cerebral hemisphere3.20e-0932
central nervous system4.38e-0982
brain6.10e-0969
future brain6.10e-0969
regional part of cerebral cortex1.33e-0822
anatomical conduit2.97e-08241
embryo4.23e-08612
multi-cellular organism5.37e-08659
embryonic structure1.62e-07605
developing anatomical structure1.62e-07605
neocortex1.72e-0720
germ layer2.90e-07604
embryonic tissue2.90e-07604
presumptive structure2.90e-07604
epiblast (generic)2.90e-07604
pre-chordal neural plate3.28e-0761
cerebral cortex5.53e-0725
pallium5.53e-0725


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
POLR3G#10622174.98052738336710.01325227943238470.046880561312835



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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