Coexpression cluster:C2317

Full id: C2317_chronic_acute_leukemia_CD34_Whole_CD133_granulocyte

Phase1 CAGE Peaks

Hg19::chr14:81893690..81893700,-	p10@STON2
Hg19::chr14:81893734..81893794,-	p3@STON2
Hg19::chr14:81893797..81893814,-	p4@STON2
Hg19::chr14:81893881..81893896,-	p7@STON2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
myeloid cell	3.44e-18	112
common myeloid progenitor	3.44e-18	112
hematopoietic stem cell	2.39e-10	172
angioblastic mesenchymal cell	2.39e-10	172
hematopoietic oligopotent progenitor cell	3.23e-09	165
hematopoietic multipotent progenitor cell	3.23e-09	165
hematopoietic cell	9.96e-09	182

Uber Anatomy

Ontology term	p-value	n
adult organism	2.27e-30	115
hematopoietic system	4.93e-10	102
blood island	4.93e-10	102
hemolymphoid system	5.96e-09	112
blood	5.84e-08	15
haemolymphatic fluid	5.84e-08	15
organism substance	5.84e-08	15

Disease

Ontology term	p-value	n
myeloid leukemia	2.23e-21	31
leukemia	8.30e-15	39
hematologic cancer	1.04e-09	51
immune system cancer	1.04e-09	51
chronic leukemia	6.81e-08	8

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ELF1#1997	4	4.25809795880754	0.00304152556578124	0.016071534964059
ESR1#2099	4	30.7686032961545	1.11467714392546e-06	4.59777907718921e-05
GABPB1#2553	4	7.06768383618217	0.000400687686442317	0.00390003926228789
GATA1#2623	4	13.5603081438004	2.95627390049268e-05	0.000613451797920832
GATA2#2624	4	12.744931733554	3.78864877853583e-05	0.000720864801933875
HEY1#23462	4	4.04011104310571	0.0037530463691798	0.0185756319487593
HMGN3#9324	3	6.13391079251294	0.00664069668332472	0.0282884415266856
JUNB#3726	3	22.9579744948659	0.000135977250401878	0.00177872345374772
MAFK#7975	2	13.550366568915	0.0077720281209805	0.0319517731430909
MAX#4149	4	6.45255550900712	0.000576761319564549	0.0048491688499438
MYC#4609	4	5.2222818716094	0.00134430939527274	0.0088668895372546
NANOG#79923	4	29.2447784810127	1.36586687657858e-06	5.32473948200786e-05
NR3C1#2908	4	14.973023331173	1.98868032687801e-05	0.000442188172575713
SMARCA4#6597	3	117.574427480916	1.03069197590886e-06	4.32654498681455e-05
SMARCB1#6598	4	18.2527157811574	9.00423392720929e-06	0.000241002867023017
STAT1#6772	4	20.7065874971992	5.43610708103893e-06	0.00016508915017058
STAT2#6773	4	65.2637711864407	5.50053512607993e-08	3.46066498814856e-06
TAF1#6872	4	3.34304628574529	0.00800566489870165	0.0321689675793737
TAL1#6886	4	29.8686166774402	1.25525650806991e-06	5.03254258910991e-05
TBP#6908	4	3.70677068709639	0.00529637781478435	0.0243795849353547
TRIM28#10155	4	18.5905250452625	8.36730015875654e-06	0.000229966437179046
ZNF263#10127	4	8.22184163701068	0.000218787118095832	0.00248341569686019

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.