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Coexpression cluster:C2597

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Full id: C2597_liver_dura_Olfactory_Nucleus_bone_Fibroblast_Hepatocyte



Phase1 CAGE Peaks

Hg19::chr1:65991226..65991233,+p11@LEPR
Hg19::chr1:65991296..65991320,+p6@LEPR
Hg19::chr1:65991324..65991417,+p2@LEPR
Hg19::chr1:65992049..65992062,+p@chr1:65992049..65992062
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism2.87e-36115
anatomical cluster3.00e-14286
neural tube9.61e-1357
neural rod9.61e-1357
future spinal cord9.61e-1357
neural keel9.61e-1357
anterior region of body1.62e-12129
craniocervical region1.62e-12129
neural plate3.07e-1286
presumptive neural plate3.07e-1286
regional part of brain4.74e-1259
head6.42e-12123
anatomical conduit3.31e-11241
neurectoderm1.03e-1090
anterior neural tube4.71e-1042
regional part of forebrain1.72e-0941
forebrain1.72e-0941
future forebrain1.72e-0941
brain3.07e-0969
future brain3.07e-0969
ectoderm-derived structure3.71e-09169
organism subdivision4.37e-09365
multi-tissue structure1.03e-08347
central nervous system1.51e-0882
ectoderm2.68e-08173
presumptive ectoderm2.68e-08173
pre-chordal neural plate4.23e-0861
regional part of nervous system8.82e-0894
nervous system8.82e-0894
multi-cellular organism1.53e-07659
telencephalon4.51e-0734
tube5.40e-07194
regional part of telencephalon9.81e-0733


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
GATA1#2623310.17023110785030.001515158168498270.00966538015879497
SUZ12#23512450.11578091106291.5827390373096e-078.81598305693748e-06
ZBTB7A#5134135.513931980906920.009038352821081090.0342497199042447
ZNF263#1012736.166381227758010.006539814347975980.0279785216569008



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.