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Coexpression cluster:C979

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Full id: C979_Mast_CD14_Eosinophils_immature_Neutrophils_CD4_Basophils



Phase1 CAGE Peaks

Hg19::chr10:35484090..35484104,+p6@CREM
Hg19::chr14:91976671..91976682,-p6@SMEK1
Hg19::chr15:52313600..52313611,+p12@MAPK6
Hg19::chr16:80404220..80404224,+p@chr16:80404220..80404224
+
Hg19::chr1:178569076..178569079,+p@chr1:178569076..178569079
+
Hg19::chr21:36260463..36260480,-p9@RUNX1
Hg19::chr3:182971089..182971100,+p12@B3GNT5
Hg19::chr3:182971130..182971148,+p3@B3GNT5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0008457beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity0.0057400211939244
GO:0030854positive regulation of granulocyte differentiation0.0057400211939244
GO:0008917lipopolysaccharide N-acetylglucosaminyltransferase activity0.0057400211939244
GO:0030852regulation of granulocyte differentiation0.0057400211939244
GO:0008140cAMP response element binding protein binding0.0137744288177509
GO:0030851granulocyte differentiation0.0153040198506013
GO:0002763positive regulation of myeloid leukocyte differentiation0.0157923462251457
GO:0016563transcription activator activity0.0157923462251457
GO:0045766positive regulation of angiogenesis0.0286764594625967
GO:0045639positive regulation of myeloid cell differentiation0.0286764594625967
GO:0009247glycolipid biosynthetic process0.0286764594625967
GO:0002761regulation of myeloid leukocyte differentiation0.0286764594625967
GO:0007275multicellular organismal development0.0334812275315464
GO:0006664glycolipid metabolic process0.0458310383064836
GO:0002573myeloid leukocyte differentiation0.0458310383064836
GO:0045637regulation of myeloid cell differentiation0.0458310383064836
GO:0004707MAP kinase activity0.0458310383064836
GO:0045765regulation of angiogenesis0.0482261591889499
GO:0008378galactosyltransferase activity0.0482261591889499



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
bone marrow3.39e-1880
hematopoietic system2.94e-17102
blood island2.94e-17102
bone element2.78e-1686
hemolymphoid system3.18e-16112
immune system9.39e-15115
skeletal element1.30e-14101
skeletal system1.30e-14101


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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