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Coexpression cluster:C3713

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Full id: C3713_CD34_Basophils_CD133_Natural_CD14_Dendritic_Mast



Phase1 CAGE Peaks

Hg19::chr18:268166..268188,+p2@AK097544
Hg19::chr3:114865016..114865037,+p@chr3:114865016..114865037
+
Hg19::chr5:43042466..43042488,-p@chr5:43042466..43042488
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte2.58e-42140
hematopoietic stem cell3.40e-40172
angioblastic mesenchymal cell3.40e-40172
hematopoietic cell5.32e-39182
hematopoietic oligopotent progenitor cell8.13e-36165
hematopoietic multipotent progenitor cell8.13e-36165
nongranular leukocyte2.14e-32119
hematopoietic lineage restricted progenitor cell2.86e-32124
lymphocyte3.98e-1953
common lymphoid progenitor3.98e-1953
lymphoid lineage restricted progenitor cell7.21e-1952
CD14-positive, CD16-negative classical monocyte3.05e-1742
myeloid leukocyte7.25e-1776
myeloid cell7.75e-17112
common myeloid progenitor7.75e-17112
mesenchymal cell4.57e-16358
classical monocyte5.47e-1645
connective tissue cell7.23e-16365
granulocyte monocyte progenitor cell1.44e-1571
motile cell5.03e-14390
macrophage dendritic cell progenitor4.61e-1365
myeloid lineage restricted progenitor cell6.88e-1370
monopoietic cell4.13e-1263
monocyte4.13e-1263
monoblast4.13e-1263
promonocyte4.13e-1263
mature alpha-beta T cell3.88e-1118
alpha-beta T cell3.88e-1118
immature T cell3.88e-1118
mature T cell3.88e-1118
immature alpha-beta T cell3.88e-1118
stem cell1.35e-10444
T cell4.47e-1025
pro-T cell4.47e-1025
multi fate stem cell5.97e-10430
somatic stem cell8.06e-10436
lymphocyte of B lineage3.64e-0824
pro-B cell3.64e-0824
B cell5.25e-0814
CD8-positive, alpha-beta T cell1.26e-0711
intermediate monocyte2.88e-079
CD14-positive, CD16-positive monocyte2.88e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.39e-15102
blood island2.39e-15102
connective tissue3.57e-15375
bone element1.34e-1486
bone marrow2.25e-1480
hemolymphoid system2.78e-13112
skeletal element5.50e-12101
skeletal system5.50e-12101
immune system4.81e-09115


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.