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Coexpression cluster:C3159

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Full id: C3159_cerebellum_parietal_hippocampus_temporal_insula_frontal_postcentral



Phase1 CAGE Peaks

Hg19::chr11:47616191..47616196,-p7@C1QTNF4
Hg19::chr17:40834385..40834392,+p6@CNTNAP1
Hg19::chr19:49941642..49941657,-p6@SLC17A7


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0015319sodium:inorganic phosphate symporter activity0.00706464146944542
GO:0015321sodium-dependent phosphate transmembrane transporter activity0.0164812521182351
GO:0005436sodium:phosphate symporter activity0.0164812521182351
GO:0015114phosphate transmembrane transporter activity0.0247167840339703
GO:0016493C-C chemokine receptor activity0.0275212931074951
GO:0019957C-C chemokine binding0.0275212931074951
GO:0001637G-protein chemoattractant receptor activity0.0275212931074951
GO:0004950chemokine receptor activity0.0275212931074951
GO:0019956chemokine binding0.0275212931074951
GO:0015296anion:cation symporter activity0.0275212931074951
GO:0005070SH3/SH2 adaptor activity0.0314253212205132
GO:0060090molecular adaptor activity0.0333704452132086
GO:0051480cytosolic calcium ion homeostasis0.0333704452132086
GO:0007204elevation of cytosolic calcium ion concentration0.0333704452132086
GO:0015103inorganic anion transmembrane transporter activity0.0333704452132086
GO:0030674protein binding, bridging0.0385573711424084
GO:0019955cytokine binding0.0385573711424084
GO:0015294solute:cation symporter activity0.0385573711424084
GO:0055074calcium ion homeostasis0.0385573711424084
GO:0006874cellular calcium ion homeostasis0.0385573711424084
GO:0006875cellular metal ion homeostasis0.0385573711424084
GO:0055065metal ion homeostasis0.0385573711424084
GO:0006817phosphate transport0.0385573711424084
GO:0042330taxis0.0385573711424084
GO:0006935chemotaxis0.0385573711424084
GO:0001653peptide receptor activity0.0385573711424084
GO:0008528peptide receptor activity, G-protein coupled0.0385573711424084
GO:0030005cellular di-, tri-valent inorganic cation homeostasis0.042863844773248
GO:0007626locomotory behavior0.042863844773248
GO:0055066di-, tri-valent inorganic cation homeostasis0.042863844773248
GO:0030003cellular cation homeostasis0.0431614103442473
GO:0055080cation homeostasis0.0431614103442473
GO:0042277peptide binding0.0431614103442473
GO:0008509anion transmembrane transporter activity0.0431614103442473
GO:0055082cellular chemical homeostasis0.0458795432522604
GO:0006873cellular ion homeostasis0.0458795432522604
GO:0015293symporter activity0.0458795432522604
GO:0015698inorganic anion transport0.0479694248685004
GO:0050801ion homeostasis0.0479878942586728



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
central nervous system1.95e-5382
brain4.39e-4969
future brain4.39e-4969
neural tube2.54e-4857
neural rod2.54e-4857
future spinal cord2.54e-4857
neural keel2.54e-4857
regional part of nervous system3.51e-4694
nervous system3.51e-4694
regional part of brain3.86e-4659
regional part of forebrain5.30e-3741
forebrain5.30e-3741
future forebrain5.30e-3741
anterior neural tube6.24e-3642
neural plate1.33e-3586
presumptive neural plate1.33e-3586
telencephalon1.48e-3334
neurectoderm1.80e-3390
gray matter2.54e-3334
brain grey matter2.54e-3334
cerebral hemisphere5.71e-3332
regional part of telencephalon1.28e-3133
regional part of cerebral cortex2.13e-3022
head4.79e-29123
pre-chordal neural plate9.11e-2861
anterior region of body4.51e-27129
craniocervical region4.51e-27129
neocortex2.71e-2620
cerebral cortex3.11e-2625
pallium3.11e-2625
adult organism4.34e-24115
ectoderm-derived structure5.83e-24169
ectoderm4.52e-23173
presumptive ectoderm4.52e-23173
posterior neural tube3.99e-1315
chordal neural plate3.99e-1315
limbic system2.96e-125
segmental subdivision of hindbrain4.58e-1112
hindbrain4.58e-1112
presumptive hindbrain4.58e-1112
organism subdivision7.10e-11365
temporal lobe1.19e-107
tube1.33e-10194
gyrus2.40e-106
segmental subdivision of nervous system4.34e-1013
regional part of metencephalon6.93e-099
metencephalon6.93e-099
future metencephalon6.93e-099
basal ganglion9.18e-099
nuclear complex of neuraxis9.18e-099
aggregate regional part of brain9.18e-099
collection of basal ganglia9.18e-099
cerebral subcortex9.18e-099
anatomical conduit1.60e-08241
nucleus of brain1.62e-089
neural nucleus1.62e-089
parietal lobe2.21e-085
middle temporal gyrus3.84e-083
occipital lobe6.95e-085
anatomical cluster7.77e-08286
epithelium8.25e-08309
cell layer1.30e-07312
pons3.06e-073


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.