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Coexpression cluster:C2885

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Full id: C2885_CD14_Endothelial_Hepatic_lymph_Lymphatic_CD4_Macrophage



Phase1 CAGE Peaks

Hg19::chr7:150434430..150434441,+p6@GIMAP5
Hg19::chr7:150434447..150434469,+p3@GIMAP5
Hg19::chr7:150434471..150434478,+p5@GIMAP5
Hg19::chr7:150434479..150434532,+p2@GIMAP5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
nongranular leukocyte6.76e-29119
hematopoietic lineage restricted progenitor cell1.22e-26124
leukocyte1.66e-25140
monopoietic cell7.18e-2363
monocyte7.18e-2363
monoblast7.18e-2363
promonocyte7.18e-2363
hematopoietic stem cell1.28e-22172
angioblastic mesenchymal cell1.28e-22172
macrophage dendritic cell progenitor4.26e-2265
hematopoietic oligopotent progenitor cell1.14e-21165
hematopoietic multipotent progenitor cell1.14e-21165
myeloid lineage restricted progenitor cell4.29e-2170
granulocyte monocyte progenitor cell4.29e-2171
CD14-positive, CD16-negative classical monocyte4.52e-2142
myeloid leukocyte2.59e-2076
hematopoietic cell3.41e-20182
classical monocyte2.25e-1845
myeloid cell7.81e-15112
common myeloid progenitor7.81e-15112
T cell9.28e-1325
pro-T cell9.28e-1325
mature alpha-beta T cell6.87e-1218
alpha-beta T cell6.87e-1218
immature T cell6.87e-1218
mature T cell6.87e-1218
immature alpha-beta T cell6.87e-1218
endothelial cell4.34e-1035
CD8-positive, alpha-beta T cell4.60e-0811
lymphoid lineage restricted progenitor cell3.25e-0752
lymphocyte7.40e-0753
common lymphoid progenitor7.40e-0753
endothelial cell of vascular tree9.17e-0724
Uber Anatomy
Ontology termp-valuen
adult organism1.56e-39115
hemolymphoid system1.56e-29112
hematopoietic system5.87e-26102
blood island5.87e-26102
immune system1.01e-21115
bone marrow5.71e-1880
bone element2.06e-1586
lateral plate mesoderm3.12e-13216
skeletal element3.11e-10101
skeletal system3.11e-10101
neural tube3.87e-1057
neural rod3.87e-1057
future spinal cord3.87e-1057
neural keel3.87e-1057
anterior neural tube1.24e-0842
regional part of forebrain3.71e-0841
forebrain3.71e-0841
future forebrain3.71e-0841
regional part of brain2.57e-0759


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.