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Coexpression cluster:C2062

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Full id: C2062_Myoblast_mesenchymal_Smooth_leiomyoma_Preadipocyte_Aortic_Fibroblast



Phase1 CAGE Peaks

Hg19::chr10:49813013..49813032,-p3@ARHGAP22
Hg19::chr10:49813051..49813064,-p4@ARHGAP22
Hg19::chr10:49813077..49813087,-p8@ARHGAP22
Hg19::chr10:49813090..49813198,-p1@ARHGAP22


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
somite1.34e-2683
paraxial mesoderm1.34e-2683
presomitic mesoderm1.34e-2683
presumptive segmental plate1.34e-2683
trunk paraxial mesoderm1.34e-2683
presumptive paraxial mesoderm1.34e-2683
vessel1.54e-2569
vasculature2.51e-2579
vascular system2.51e-2579
blood vessel1.39e-2460
epithelial tube open at both ends1.39e-2460
blood vasculature1.39e-2460
vascular cord1.39e-2460
artery1.66e-2342
arterial blood vessel1.66e-2342
arterial system1.66e-2342
dermomyotome2.42e-2370
multilaminar epithelium1.93e-2282
anatomical system1.00e-20625
anatomical group1.39e-20626
splanchnic layer of lateral plate mesoderm4.32e-2084
cardiovascular system1.62e-19110
skeletal muscle tissue5.18e-1961
striated muscle tissue5.18e-1961
myotome5.18e-1961
circulatory system5.34e-19113
multi-cellular organism5.77e-19659
systemic artery6.34e-1933
systemic arterial system6.34e-1933
muscle tissue3.30e-1863
musculature3.30e-1863
musculature of body3.30e-1863
cell layer3.86e-18312
epithelium1.84e-17309
anatomical conduit6.63e-17241
trunk mesenchyme3.89e-16143
epithelial tube7.40e-16118
musculoskeletal system7.67e-16167
tube1.12e-15194
anatomical cluster4.68e-14286
germ layer8.16e-14604
embryonic tissue8.16e-14604
presumptive structure8.16e-14604
epiblast (generic)8.16e-14604
embryonic structure1.07e-13605
developing anatomical structure1.07e-13605
organism subdivision2.73e-13365
lateral plate mesoderm5.01e-13216
embryo1.49e-12612
aorta4.83e-1221
aortic system4.83e-1221
unilaminar epithelium1.64e-11138
tissue7.45e-11787
mesoderm7.73e-10448
mesoderm-derived structure7.73e-10448
presumptive mesoderm7.73e-10448
blood vessel smooth muscle5.13e-0810
arterial system smooth muscle5.13e-0810
artery smooth muscle tissue5.13e-0810
aorta smooth muscle tissue5.13e-0810
surface structure7.60e-0895
integument1.05e-0745
integumental system1.05e-0745
trunk2.68e-07216


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.