Coexpression cluster:C1560

Full id: C1560_CD14_Dendritic_Macrophage_dura_Monocytederived_lymph_left

Phase1 CAGE Peaks

Hg19::chr10:105610433..105610453,-	p@chr10:105610433..105610453 -
Hg19::chr11:117860734..117860750,+	p@chr11:117860734..117860750 +
Hg19::chr17:6983594..6983619,-	p2@CLEC10A
Hg19::chr19:7812446..7812473,-	p3@CD209
Hg19::chr19:7812475..7812509,-	p1@CD209

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0010324	membrane invagination	0.00108911619621619
GO:0006897	endocytosis	0.00108911619621619
GO:0016044	membrane organization and biogenesis	0.00108911619621619
GO:0005529	sugar binding	0.00108911619621619
GO:0046795	intracellular virion transport	0.00108911619621619
GO:0046794	virion transport	0.00108911619621619
GO:0046968	peptide antigen transport	0.00108911619621619
GO:0042607	exogenous peptide antigen binding	0.00108911619621619
GO:0019062	virion attachment to host cell surface receptor	0.00145213355452384
GO:0030246	carbohydrate binding	0.00146200395893184
GO:0046790	virion binding	0.00195906581209551
GO:0016192	vesicle-mediated transport	0.00195906581209551
GO:0007159	leukocyte adhesion	0.00208325063589046
GO:0044409	entry into host	0.00208325063589046
GO:0030260	entry into host cell	0.00208325063589046
GO:0046718	entry of virus into host cell	0.00208325063589046
GO:0007157	heterophilic cell adhesion	0.00208325063589046
GO:0052126	movement in host environment	0.00208325063589046
GO:0019048	virus-host interaction	0.00208325063589046
GO:0051828	entry into other organism during symbiotic interaction	0.00208325063589046
GO:0019059	initiation of viral infection	0.00208325063589046
GO:0051806	entry into cell of other organism during symbiotic interaction	0.00208325063589046
GO:0052192	movement in environment of other organism during symbiotic interaction	0.00208325063589046
GO:0005537	mannose binding	0.00217791178596612
GO:0009405	pathogenesis	0.00226499491433228
GO:0009988	cell-cell recognition	0.00234537440810924
GO:0048029	monosaccharide binding	0.0027423537189971
GO:0042605	peptide antigen binding	0.0027999249712539
GO:0006955	immune response	0.00312321995174038
GO:0051701	interaction with host	0.00319380039659979
GO:0002376	immune system process	0.00394647724338942
GO:0019079	viral genome replication	0.00394647724338942
GO:0044403	symbiosis, encompassing mutualism through parasitism	0.00409839166688678
GO:0044419	interspecies interaction between organisms	0.00409839166688678
GO:0008037	cell recognition	0.00471693332176563
GO:0015833	peptide transport	0.00471693332176563
GO:0019058	viral infectious cycle	0.00588295535511979
GO:0022415	viral reproductive process	0.00652940717060383
GO:0048002	antigen processing and presentation of peptide antigen	0.0117111623236994
GO:0016043	cellular component organization and biogenesis	0.0172092766472403
GO:0003823	antigen binding	0.0187587343868919
GO:0042277	peptide binding	0.0215094572875855
GO:0005886	plasma membrane	0.0217088453958351
GO:0006810	transport	0.0237207834844514
GO:0051234	establishment of localization	0.0243576701727509
GO:0051179	localization	0.0279832014671252
GO:0022414	reproductive process	0.0281445955333581
GO:0051704	multi-organism process	0.0300757319177876
GO:0016337	cell-cell adhesion	0.0306942244842114
GO:0019882	antigen processing and presentation	0.0359388563332375

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
monopoietic cell	8.38e-35	63
monocyte	8.38e-35	63
monoblast	8.38e-35	63
promonocyte	8.38e-35	63
macrophage dendritic cell progenitor	1.91e-34	65
myeloid leukocyte	4.62e-33	76
granulocyte monocyte progenitor cell	1.92e-31	71
myeloid lineage restricted progenitor cell	7.18e-31	70
CD14-positive, CD16-negative classical monocyte	2.06e-27	42
classical monocyte	2.30e-24	45
myeloid cell	3.91e-22	112
common myeloid progenitor	3.91e-22	112
leukocyte	1.50e-19	140
nongranular leukocyte	3.16e-18	119
hematopoietic lineage restricted progenitor cell	8.62e-16	124
hematopoietic stem cell	3.23e-15	172
angioblastic mesenchymal cell	3.23e-15	172
hematopoietic cell	3.01e-13	182
hematopoietic oligopotent progenitor cell	3.42e-13	165
hematopoietic multipotent progenitor cell	3.42e-13	165
intermediate monocyte	4.06e-07	9
CD14-positive, CD16-positive monocyte	4.06e-07	9

Uber Anatomy

Ontology term	p-value	n
adult organism	1.38e-34	115
hematopoietic system	6.01e-32	102
blood island	6.01e-32	102
hemolymphoid system	1.73e-31	112
bone marrow	5.74e-26	80
bone element	1.95e-22	86
immune system	4.69e-22	115
skeletal element	1.72e-17	101
skeletal system	1.72e-17	101
lateral plate mesoderm	2.32e-13	216
musculoskeletal system	8.20e-09	167

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.