UBERON:0009551
From FANTOM5_SSTAR
| Name: | distal segment of digit |
|---|---|
| Definition: | "A segment of a digit containing the distal phalanx, and overlapping the interphalangeal joint[CJM]. The digit tip is derived from multiple and distinct embryonic origins, and includes the distal bone with associated marrow cavity and haematopoietic cells, ventral (flexor) and dorsal (extensor) tendons, sweat glands with myoepithelial and luminal secreting cells and associated neurons for innervation, dermis with resident melanocytes and dendritic cells, mesenchyme with resident fibroblasts, skin epidermis with hair follicles, a nail organ composed of six specific parts (the root, nail bed, nail plate, eponychium (cuticle), perionychium and hyponychium)." [doi:10.1038/nature10346] |
| Synonyms: |
"digit tip" EXACT [UBERON:cjm] "distal digit segment" EXACT [UBERON:cjm] "tip of digit" EXACT [UBERON:cjm] |
| Comments: | Newborn and adult mice are able to regrow forelimb (finger) and hindlimb (toe) digit tips after their amputation through the distal interphalangeal joint. Regeneration of the digit tip involves the integrated regrowth of multiple tissues within 2窶�3窶盈onths, reaching an external morphology that is cosmetically and functionally similar to normal digits. Most importantly, regeneration of the mouse distal digit shares morphological similarities with clinical cases documenting regrowth of missing distal portions of fingers in both children and adults |
Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | UBERON:0000914(),UBERON:0004120(mesoderm-derived structure) |
|---|---|
| part_of: | UBERON:0002544(digit) |
Children
| part of: | UBERON:0009564 (distal limb integumentary appendage) |
|---|
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology
Human (Homo sapiens)
- 10273-104E3
- 10301-104H4 (Fingernail (including nail plate, eponychium and hyponychium), donor2)
- 10329-105B5
Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0009551 (distal segment of digit), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
No analysis results
