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Coexpression cluster:C954

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Full id: C954_heart_CD14_Neutrophils_Eosinophils_Lymphatic_renal_Monocytederived



Phase1 CAGE Peaks

Hg19::chr6:160100686..160100698,-p4@AK093984
Hg19::chr6:160101581..160101593,-p18@SOD2
Hg19::chr6:160101609..160101626,-p21@SOD2
Hg19::chr6:160101648..160101695,-p7@SOD2
Hg19::chr6:160102006..160102195,-p1@BC041951
Hg19::chr6:160102208..160102232,-p6@BC041951
Hg19::chr6:160102300..160102326,-p5@BC041951
Hg19::chr6:160102610..160102627,-p3@BC041951
Hg19::chr6:160112805..160112821,-p@chr6:160112805..160112821
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0008383manganese superoxide dismutase activity0.0027375485694101
GO:0001315age-dependent response to reactive oxygen species0.0027375485694101
GO:0000303response to superoxide0.00342193571176262
GO:0000305response to oxygen radical0.00342193571176262
GO:0016721oxidoreductase activity, acting on superoxide radicals as acceptor0.00410632285411515
GO:0004784superoxide dismutase activity0.00410632285411515
GO:0001836release of cytochrome c from mitochondria0.00508401877176161
GO:0008637apoptotic mitochondrial changes0.00574885199576121
GO:0042542response to hydrogen peroxide0.00574885199576121
GO:0006801superoxide metabolic process0.00574885199576121
GO:0000302response to reactive oxygen species0.00671943739764298
GO:0006302double-strand break repair0.0082126457082303
GO:0006800oxygen and reactive oxygen species metabolic process0.00947612966334266
GO:0008632apoptotic program0.0162427881784999
GO:0007005mitochondrion organization and biogenesis0.0162427881784999
GO:0006979response to oxidative stress0.0205316142705758
GO:0030145manganese ion binding0.0236717435119579
GO:0031980mitochondrial lumen0.0263669151685289
GO:0005759mitochondrial matrix0.0263669151685289
GO:0043066negative regulation of apoptosis0.0299826748078249
GO:0043069negative regulation of programmed cell death0.0299826748078249
GO:0005743mitochondrial inner membrane0.0389478501011528
GO:0019866organelle inner membrane0.0393968946293367
GO:0006281DNA repair0.0438007771105616
GO:0031966mitochondrial membrane0.0438007771105616
GO:0006357regulation of transcription from RNA polymerase II promoter0.0438007771105616
GO:0005740mitochondrial envelope0.0438007771105616
GO:0006974response to DNA damage stimulus0.0438007771105616
GO:0009719response to endogenous stimulus0.0486675301228462
GO:0042981regulation of apoptosis0.0486675301228462
GO:0043067regulation of programmed cell death0.0486675301228462
GO:0044429mitochondrial part0.0486675301228462
GO:0042221response to chemical stimulus0.0486675301228462
GO:0031967organelle envelope0.0486675301228462
GO:0031975envelope0.0486675301228462
GO:0006366transcription from RNA polymerase II promoter0.0486675301228462



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
adult organism1.26e-14115
hematopoietic system1.86e-11102
blood island1.86e-11102
hemolymphoid system2.26e-11112
musculoskeletal system3.03e-11167
bone marrow2.31e-1080
bone element3.95e-0986
skeletal element1.17e-08101
skeletal system1.17e-08101
immune system2.24e-08115
mesoderm2.35e-08448
mesoderm-derived structure2.35e-08448
presumptive mesoderm2.35e-08448
embryonic structure8.97e-08605
developing anatomical structure8.97e-08605
germ layer9.82e-08604
embryonic tissue9.82e-08604
presumptive structure9.82e-08604
epiblast (generic)9.82e-08604
embryo2.71e-07612


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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