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Coexpression cluster:C468

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Full id: C468_Neutrophils_Eosinophils_cerebellum_occipital_Whole_temporal_parietal



Phase1 CAGE Peaks

Hg19::chr11:74459876..74459930,+p1@RNF169
Hg19::chr12:76953574..76953598,-p3@OSBPL8
Hg19::chr14:52327421..52327458,+p3@GNG2
Hg19::chr17:11924129..11924200,+p1@MAP2K4
Hg19::chr17:47439568..47439641,-p2@ZNF652
Hg19::chr1:89149914..89149995,+p1@PKN2
Hg19::chr20:60813535..60813592,+p2@OSBPL2
Hg19::chr2:139259324..139259389,+p1@SPOPL
Hg19::chr2:160472952..160473077,-p1@BAZ2B
Hg19::chr2:201936328..201936416,-p1@FAM126B
Hg19::chr2:24714108..24714152,+p@chr2:24714108..24714152
+
Hg19::chr2:86850949..86851023,-p1@RNF103
Hg19::chr3:184529948..184529990,+p1@VPS8
Hg19::chr4:6784401..6784510,+p1@KIAA0232
Hg19::chr4:89513578..89513670,+p1@HERC3
Hg19::chr5:112043186..112043225,+p2@APC
Hg19::chr6:137113489..137113569,-p1@MAP3K5
Hg19::chr6:42531690..42531718,+p2@UBR2
Hg19::chr7:30634347..30634400,-p1@uc003tbj.2
p1@uc003tbl.3
p1@uc010kvv.2
Hg19::chr8:52811714..52811731,-p3@PCMTD1
Hg19::chrX:80065146..80065250,-p1@BRWD3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0006464protein modification process0.0195237347183443
GO:0043412biopolymer modification0.0195237347183443
GO:0051983regulation of chromosome segregation0.0195237347183443
GO:0051988regulation of attachment of spindle microtubules to kinetochore0.0195237347183443
GO:0008608attachment of spindle microtubules to kinetochore0.0195237347183443
GO:0007254JNK cascade0.0195237347183443
GO:0031098stress-activated protein kinase signaling pathway0.0195237347183443
GO:0043687post-translational protein modification0.0216695468435289



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism2.92e-45115
neural tube9.21e-2557
neural rod9.21e-2557
future spinal cord9.21e-2557
neural keel9.21e-2557
anterior neural tube4.58e-2242
regional part of forebrain7.56e-2241
forebrain7.56e-2241
future forebrain7.56e-2241
regional part of brain3.44e-2159
central nervous system5.70e-2182
hematopoietic system1.68e-20102
blood island1.68e-20102
brain2.81e-2069
future brain2.81e-2069
regional part of nervous system2.38e-1894
nervous system2.38e-1894
telencephalon4.28e-1834
gray matter4.81e-1834
brain grey matter4.81e-1834
hemolymphoid system1.16e-17112
regional part of telencephalon1.66e-1733
cerebral hemisphere4.43e-1732
bone marrow1.64e-1480
regional part of cerebral cortex2.71e-1422
bone element2.28e-1386
cerebral cortex3.50e-1325
pallium3.50e-1325
neural plate4.14e-1386
presumptive neural plate4.14e-1386
neocortex4.50e-1320
neurectoderm6.55e-1390
skeletal element1.54e-11101
skeletal system1.54e-11101
anterior region of body1.45e-10129
craniocervical region1.45e-10129
pre-chordal neural plate4.62e-1061
head1.54e-09123
immune system3.58e-09115
ectoderm2.91e-07173
presumptive ectoderm2.91e-07173
ectoderm-derived structure3.17e-07169


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.