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Coexpression cluster:C3119

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Full id: C3119_CD4_mature_CD8_Neutrophils_Eosinophils_Natural_granulocyte



Phase1 CAGE Peaks

Hg19::chr11:14665263..14665274,+p5@PDE3B
Hg19::chr11:14665275..14665316,+p2@PDE3B
Hg19::chr11:14665329..14665356,+p1@PDE3B


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
hematopoietic stem cell3.09e-32172
angioblastic mesenchymal cell3.09e-32172
hematopoietic oligopotent progenitor cell7.51e-30165
hematopoietic multipotent progenitor cell7.51e-30165
hematopoietic cell1.57e-27182
leukocyte4.69e-26140
nongranular leukocyte2.23e-24119
myeloid cell2.31e-21112
common myeloid progenitor2.31e-21112
hematopoietic lineage restricted progenitor cell5.27e-20124
myeloid leukocyte5.80e-1776
monopoietic cell1.62e-1563
monocyte1.62e-1563
monoblast1.62e-1563
promonocyte1.62e-1563
macrophage dendritic cell progenitor1.49e-1465
myeloid lineage restricted progenitor cell1.64e-1370
classical monocyte8.29e-1345
granulocyte monocyte progenitor cell9.32e-1371
CD14-positive, CD16-negative classical monocyte5.40e-1242
T cell6.50e-1125
pro-T cell6.50e-1125
mature alpha-beta T cell1.34e-1018
alpha-beta T cell1.34e-1018
immature T cell1.34e-1018
mature T cell1.34e-1018
immature alpha-beta T cell1.34e-1018
CD8-positive, alpha-beta T cell3.53e-0811
lymphocyte4.93e-0853
common lymphoid progenitor4.93e-0853
lymphoid lineage restricted progenitor cell8.31e-0852
Uber Anatomy
Ontology termp-valuen
adult organism3.06e-17115
hematopoietic system1.44e-14102
blood island1.44e-14102
hemolymphoid system1.08e-11112
bone marrow3.00e-0980
immune system3.08e-09115
bone element1.51e-0786
Disease
Ontology termp-valuen
leukemia5.86e-0739


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.