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Coexpression cluster:C1560

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Full id: C1560_CD14_Dendritic_Macrophage_dura_Monocytederived_lymph_left



Phase1 CAGE Peaks

Hg19::chr10:105610433..105610453,-p@chr10:105610433..105610453
-
Hg19::chr11:117860734..117860750,+p@chr11:117860734..117860750
+
Hg19::chr17:6983594..6983619,-p2@CLEC10A
Hg19::chr19:7812446..7812473,-p3@CD209
Hg19::chr19:7812475..7812509,-p1@CD209


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0010324membrane invagination0.00108911619621619
GO:0006897endocytosis0.00108911619621619
GO:0016044membrane organization and biogenesis0.00108911619621619
GO:0005529sugar binding0.00108911619621619
GO:0046795intracellular virion transport0.00108911619621619
GO:0046794virion transport0.00108911619621619
GO:0046968peptide antigen transport0.00108911619621619
GO:0042607exogenous peptide antigen binding0.00108911619621619
GO:0019062virion attachment to host cell surface receptor0.00145213355452384
GO:0030246carbohydrate binding0.00146200395893184
GO:0046790virion binding0.00195906581209551
GO:0016192vesicle-mediated transport0.00195906581209551
GO:0007159leukocyte adhesion0.00208325063589046
GO:0044409entry into host0.00208325063589046
GO:0030260entry into host cell0.00208325063589046
GO:0046718entry of virus into host cell0.00208325063589046
GO:0007157heterophilic cell adhesion0.00208325063589046
GO:0052126movement in host environment0.00208325063589046
GO:0019048virus-host interaction0.00208325063589046
GO:0051828entry into other organism during symbiotic interaction0.00208325063589046
GO:0019059initiation of viral infection0.00208325063589046
GO:0051806entry into cell of other organism during symbiotic interaction0.00208325063589046
GO:0052192movement in environment of other organism during symbiotic interaction0.00208325063589046
GO:0005537mannose binding0.00217791178596612
GO:0009405pathogenesis0.00226499491433228
GO:0009988cell-cell recognition0.00234537440810924
GO:0048029monosaccharide binding0.0027423537189971
GO:0042605peptide antigen binding0.0027999249712539
GO:0006955immune response0.00312321995174038
GO:0051701interaction with host0.00319380039659979
GO:0002376immune system process0.00394647724338942
GO:0019079viral genome replication0.00394647724338942
GO:0044403symbiosis, encompassing mutualism through parasitism0.00409839166688678
GO:0044419interspecies interaction between organisms0.00409839166688678
GO:0008037cell recognition0.00471693332176563
GO:0015833peptide transport0.00471693332176563
GO:0019058viral infectious cycle0.00588295535511979
GO:0022415viral reproductive process0.00652940717060383
GO:0048002antigen processing and presentation of peptide antigen0.0117111623236994
GO:0016043cellular component organization and biogenesis0.0172092766472403
GO:0003823antigen binding0.0187587343868919
GO:0042277peptide binding0.0215094572875855
GO:0005886plasma membrane0.0217088453958351
GO:0006810transport0.0237207834844514
GO:0051234establishment of localization0.0243576701727509
GO:0051179localization0.0279832014671252
GO:0022414reproductive process0.0281445955333581
GO:0051704multi-organism process0.0300757319177876
GO:0016337cell-cell adhesion0.0306942244842114
GO:0019882antigen processing and presentation0.0359388563332375



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
monopoietic cell8.38e-3563
monocyte8.38e-3563
monoblast8.38e-3563
promonocyte8.38e-3563
macrophage dendritic cell progenitor1.91e-3465
myeloid leukocyte4.62e-3376
granulocyte monocyte progenitor cell1.92e-3171
myeloid lineage restricted progenitor cell7.18e-3170
CD14-positive, CD16-negative classical monocyte2.06e-2742
classical monocyte2.30e-2445
myeloid cell3.91e-22112
common myeloid progenitor3.91e-22112
leukocyte1.50e-19140
nongranular leukocyte3.16e-18119
hematopoietic lineage restricted progenitor cell8.62e-16124
hematopoietic stem cell3.23e-15172
angioblastic mesenchymal cell3.23e-15172
hematopoietic cell3.01e-13182
hematopoietic oligopotent progenitor cell3.42e-13165
hematopoietic multipotent progenitor cell3.42e-13165
intermediate monocyte4.06e-079
CD14-positive, CD16-positive monocyte4.06e-079
Uber Anatomy
Ontology termp-valuen
adult organism1.38e-34115
hematopoietic system6.01e-32102
blood island6.01e-32102
hemolymphoid system1.73e-31112
bone marrow5.74e-2680
bone element1.95e-2286
immune system4.69e-22115
skeletal element1.72e-17101
skeletal system1.72e-17101
lateral plate mesoderm2.32e-13216
musculoskeletal system8.20e-09167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.