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Coexpression cluster:C1418

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Full id: C1418_insula_temporal_frontal_brain_occipital_paracentral_nucleus



Phase1 CAGE Peaks

Hg19::chr16:13901928..13901942,-p@chr16:13901928..13901942
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Hg19::chr1:208443938..208443947,-p@chr1:208443938..208443947
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Hg19::chr3:68040679..68040716,+p4@FAM19A1
Hg19::chr5:136535737..136535749,-p@chr5:136535737..136535749
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Hg19::chr5:136535760..136535778,-p@chr5:136535760..136535778
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Hg19::chr9:135036765..135036814,+p5@NTNG2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0046658anchored to plasma membrane0.0216310063372877
GO:0031225anchored to membrane0.0216310063372877
GO:0007409axonogenesis0.0464561149167197
GO:0048667neuron morphogenesis during differentiation0.0464561149167197
GO:0048812neurite morphogenesis0.0464561149167197
GO:0000904cellular morphogenesis during differentiation0.0464561149167197
GO:0048503GPI anchor binding0.0464561149167197
GO:0031175neurite development0.0464561149167197
GO:0048666neuron development0.0464561149167197
GO:0032990cell part morphogenesis0.0464561149167197
GO:0030030cell projection organization and biogenesis0.0464561149167197
GO:0048858cell projection morphogenesis0.0464561149167197
GO:0030182neuron differentiation0.0464561149167197
GO:0048699generation of neurons0.0470559676737943
GO:0035091phosphoinositide binding0.0470559676737943
GO:0022008neurogenesis0.0470559676737943



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
regional part of cerebral cortex4.76e-2722
central nervous system6.09e-2682
regional part of forebrain6.77e-2541
forebrain6.77e-2541
future forebrain6.77e-2541
brain8.41e-2569
future brain8.41e-2569
neocortex4.35e-2420
anterior neural tube4.36e-2442
cerebral cortex4.30e-2325
pallium4.30e-2325
telencephalon5.67e-2334
cerebral hemisphere8.12e-2332
gray matter1.31e-2234
brain grey matter1.31e-2234
neural tube1.83e-2257
neural rod1.83e-2257
future spinal cord1.83e-2257
neural keel1.83e-2257
regional part of nervous system1.02e-2194
nervous system1.02e-2194
regional part of telencephalon1.44e-2133
regional part of brain2.43e-2159
neural plate2.06e-1586
presumptive neural plate2.06e-1586
pre-chordal neural plate6.40e-1561
neurectoderm3.11e-1490
adult organism4.14e-14115
anterior region of body1.57e-10129
craniocervical region1.57e-10129
head2.58e-10123
occipital lobe3.34e-095
parietal lobe4.55e-095
ectoderm-derived structure3.82e-08169
temporal lobe7.03e-087
gyrus7.70e-086
ectoderm1.09e-07173
presumptive ectoderm1.09e-07173


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.