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Coexpression cluster:C103

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Full id: C103_CD4_CD8_Natural_Peripheral_Whole_Neutrophils_Basophils



Phase1 CAGE Peaks

Hg19::chr10:116561109..116561139,-p@chr10:116561109..116561139
-
Hg19::chr10:116561206..116561217,-p@chr10:116561206..116561217
-
Hg19::chr10:120850774..120850786,+p@chr10:120850774..120850786
+
Hg19::chr10:127684545..127684563,+p@chr10:127684545..127684563
+
Hg19::chr10:127684574..127684597,+p@chr10:127684574..127684597
+
Hg19::chr10:127684603..127684610,+p@chr10:127684603..127684610
+
Hg19::chr10:127684797..127684804,+p@chr10:127684797..127684804
+
Hg19::chr10:17697543..17697546,-p@chr10:17697543..17697546
-
Hg19::chr10:17755334..17755338,+p@chr10:17755334..17755338
+
Hg19::chr10:33403410..33403417,-p@chr10:33403410..33403417
-
Hg19::chr10:33403568..33403605,+p@chr10:33403568..33403605
+
Hg19::chr10:33405656..33405667,-p3@ENST00000414308
Hg19::chr10:33405703..33405713,-p2@ENST00000414308
Hg19::chr10:33405727..33405751,-p1@ENST00000414308
Hg19::chr10:33423233..33423255,+p@chr10:33423233..33423255
+
Hg19::chr10:33428350..33428361,+p@chr10:33428350..33428361
+
Hg19::chr10:6337053..6337076,+p@chr10:6337053..6337076
+
Hg19::chr10:6342353..6342370,+p@chr10:6342353..6342370
+
Hg19::chr10:63807238..63807249,+p@chr10:63807238..63807249
+
Hg19::chr10:63810303..63810331,+p@chr10:63810303..63810331
+
Hg19::chr10:63810855..63810875,-p@chr10:63810855..63810875
-
Hg19::chr10:63810885..63810913,-p@chr10:63810885..63810913
-
Hg19::chr10:63978845..63978868,+p@chr10:63978845..63978868
+
Hg19::chr10:63978876..63978886,+p@chr10:63978876..63978886
+
Hg19::chr10:63995871..63995888,-p4@RTKN2
Hg19::chr10:63996620..63996627,-p@chr10:63996620..63996627
-
Hg19::chr10:63999878..63999893,-p@chr10:63999878..63999893
-
Hg19::chr10:63999898..63999909,-p@chr10:63999898..63999909
-
Hg19::chr11:111410267..111410269,+p@chr11:111410267..111410269
+
Hg19::chr11:117150937..117150942,+p@chr11:117150937..117150942
+
Hg19::chr11:117150945..117150958,+p@chr11:117150945..117150958
+
Hg19::chr11:121322289..121322304,+p@chr11:121322289..121322304
+
Hg19::chr11:121322360..121322393,+p@chr11:121322360..121322393
+
Hg19::chr11:121322394..121322417,+p12@SORL1
Hg19::chr12:12619140..12619146,-p1@CU680647
Hg19::chr12:12619407..12619418,+p@chr12:12619407..12619418
+
Hg19::chr12:12628211..12628227,+p@chr12:12628211..12628227
+
Hg19::chr12:12628251..12628264,+p@chr12:12628251..12628264
+
Hg19::chr12:12635181..12635187,-p@chr12:12635181..12635187
-
Hg19::chr12:12635397..12635432,+p@chr12:12635397..12635432
+
Hg19::chr12:12635434..12635452,+p@chr12:12635434..12635452
+
Hg19::chr12:12635461..12635484,+p@chr12:12635461..12635484
+
Hg19::chr12:12713961..12713976,-p14@DUSP16
Hg19::chr12:12714006..12714021,-p15@DUSP16
Hg19::chr12:12714025..12714064,-p4@DUSP16
Hg19::chr12:12714066..12714108,+p@chr12:12714066..12714108
+
Hg19::chr12:12775594..12775630,-p@chr12:12775594..12775630
-
Hg19::chr12:56418637..56418648,+p9@IKZF4
Hg19::chr12:92445353..92445356,-p@chr12:92445353..92445356
-
Hg19::chr13:30510003..30510027,+p1@ENST00000400540
Hg19::chr13:40765017..40765053,-p@chr13:40765017..40765053
-
Hg19::chr13:48984656..48984665,+p@chr13:48984656..48984665
+
Hg19::chr13:75900881..75900923,-p2@TBC1D4
Hg19::chr13:87409604..87409610,-p@chr13:87409604..87409610
-
Hg19::chr13:99967027..99967041,+p16@UBAC2
Hg19::chr14:22976236..22976240,-p@chr14:22976236..22976240
-
Hg19::chr14:23004404..23004417,+p@chr14:23004404..23004417
+
Hg19::chr14:91712613..91712627,+p@chr14:91712613..91712627
+
Hg19::chr14:91777214..91777217,+p@chr14:91777214..91777217
+
Hg19::chr14:99707456..99707462,-p@chr14:99707456..99707462
-
Hg19::chr15:22550911..22550920,+p@chr15:22550911..22550920
+
Hg19::chr15:22550947..22550971,+p@chr15:22550947..22550971
+
Hg19::chr15:38964056..38964101,+p1@ENST00000557946
Hg19::chr15:62149711..62149734,-p@chr15:62149711..62149734
-
Hg19::chr15:63961074..63961079,+p@chr15:63961074..63961079
+
Hg19::chr15:63965111..63965141,-p@chr15:63965111..63965141
-
Hg19::chr16:50372905..50372915,-p@chr16:50372905..50372915
-
Hg19::chr16:57162957..57162973,+p@chr16:57162957..57162973
+
Hg19::chr16:57164428..57164453,+p@chr16:57164428..57164453
+
Hg19::chr17:29645688..29645699,+p@chr17:29645688..29645699
+
Hg19::chr17:29645703..29645717,+p@chr17:29645703..29645717
+
Hg19::chr17:29645772..29645777,+p@chr17:29645772..29645777
+
Hg19::chr18:13276704..13276707,-p@chr18:13276704..13276707
-
Hg19::chr18:13377159..13377168,+p@chr18:13377159..13377168
+
Hg19::chr18:13383177..13383191,-p@chr18:13383177..13383191
-
Hg19::chr18:21572756..21572768,+p18@TTC39C
Hg19::chr18:21572789..21572809,+p11@TTC39C
Hg19::chr18:21572813..21572830,+p16@TTC39C
Hg19::chr18:21572835..21572856,+p10@TTC39C
Hg19::chr18:21572860..21572883,+p12@TTC39C
Hg19::chr18:2606630..2606643,+p@chr18:2606630..2606643
+
Hg19::chr1:100889590..100889601,-p@chr1:100889590..100889601
-
Hg19::chr1:100889615..100889640,-p@chr1:100889615..100889640
-
Hg19::chr1:108329149..108329182,-p@chr1:108329149..108329182
-
Hg19::chr1:118197380..118197387,+p@chr1:118197380..118197387
+
Hg19::chr1:118198855..118198873,-p@chr1:118198855..118198873
-
Hg19::chr1:118198878..118198907,-p@chr1:118198878..118198907
-
Hg19::chr1:118198995..118199007,+p@chr1:118198995..118199007
+
Hg19::chr1:118201616..118201641,+p@chr1:118201616..118201641
+
Hg19::chr1:118207256..118207267,+p@chr1:118207256..118207267
+
Hg19::chr1:154377675..154377692,+p7@IL6R
Hg19::chr1:158900568..158900580,+p4@PYHIN1
Hg19::chr1:169652514..169652517,+p@chr1:169652514..169652517
+
Hg19::chr1:184861491..184861522,-p@chr1:184861491..184861522
-
Hg19::chr1:186287725..186287734,-p@chr1:186287725..186287734
-
Hg19::chr1:186290177..186290204,-p@chr1:186290177..186290204
-
Hg19::chr1:186293145..186293167,-p@chr1:186293145..186293167
-
Hg19::chr1:186293180..186293185,-p@chr1:186293180..186293185
-
Hg19::chr1:193426391..193426402,+p@chr1:193426391..193426402
+
Hg19::chr1:193428096..193428112,+p@chr1:193428096..193428112
+
Hg19::chr1:193448401..193448412,-p@chr1:193448401..193448412
-
Hg19::chr1:200842103..200842116,+p1@GPR25
Hg19::chr1:25255894..25255906,+p@chr1:25255894..25255906
+
Hg19::chr1:40854406..40854413,+p@chr1:40854406..40854413
+
Hg19::chr1:8213538..8213546,-p@chr1:8213538..8213546
-
Hg19::chr20:44521809..44521827,+p11@CTSA
Hg19::chr20:4642112..4642117,+p@chr20:4642112..4642117
+
Hg19::chr20:47438166..47438202,-p@chr20:47438166..47438202
-
Hg19::chr20:57740067..57740074,+p@chr20:57740067..57740074
+
Hg19::chr21:32568033..32568068,-p@chr21:32568033..32568068
-
Hg19::chr21:47971523..47971557,+p@chr21:47971523..47971557
+
Hg19::chr2:112224582..112224600,+p@chr2:112224582..112224600
+
Hg19::chr2:158297507..158297544,-p@chr2:158297507..158297544
-
Hg19::chr2:198562922..198562964,+p@chr2:198562922..198562964
+
Hg19::chr2:204571443..204571454,+p5@CD28
Hg19::chr2:204718698..204718703,+p@chr2:204718698..204718703
+
Hg19::chr2:204732487..204732521,+p1@CTLA4
Hg19::chr2:204732524..204732537,+p3@CTLA4
Hg19::chr2:204732580..204732598,+p2@CTLA4
Hg19::chr2:204732682..204732693,+p4@CTLA4
Hg19::chr2:204736259..204736275,-p@chr2:204736259..204736275
-
Hg19::chr2:204736545..204736556,+p@chr2:204736545..204736556
+
Hg19::chr2:204891853..204891863,-p@chr2:204891853..204891863
-
Hg19::chr2:213963849..213963858,-p@chr2:213963849..213963858
-
Hg19::chr2:213963876..213963889,-p@chr2:213963876..213963889
-
Hg19::chr2:214012337..214012351,-p@chr2:214012337..214012351
-
Hg19::chr2:214012365..214012410,-p@chr2:214012365..214012410
-
Hg19::chr2:241975597..241975616,+p@chr2:241975597..241975616
+
Hg19::chr3:114012819..114012830,+p4@TIGIT
Hg19::chr3:114012837..114012850,+p2@TIGIT
Hg19::chr3:114012855..114012862,+p5@TIGIT
Hg19::chr3:114012867..114012887,+p1@TIGIT
Hg19::chr3:183067487..183067500,+p@chr3:183067487..183067500
+
Hg19::chr3:183067510..183067522,+p@chr3:183067510..183067522
+
Hg19::chr3:33086412..33086426,+p@chr3:33086412..33086426
+
Hg19::chr3:45986539..45986570,+p2@CXCR6
Hg19::chr3:56627780..56627823,+p1@HQ234308
Hg19::chr3:60033427..60033438,+p@chr3:60033427..60033438
+
Hg19::chr3:66353087..66353127,+p@chr3:66353087..66353127
+
Hg19::chr3:66444556..66444563,-p@chr3:66444556..66444563
-
Hg19::chr3:71551472..71551476,-p@chr3:71551472..71551476
-
Hg19::chr3:73010101..73010107,+p@chr3:73010101..73010107
+
Hg19::chr3:73015629..73015632,+p@chr3:73015629..73015632
+
Hg19::chr4:78722513..78722551,-p@chr4:78722513..78722551
-
Hg19::chr5:126189802..126189808,-p@chr5:126189802..126189808
-
Hg19::chr5:67576339..67576353,+p8@PIK3R1
Hg19::chr5:75839276..75839297,+p@chr5:75839276..75839297
+
Hg19::chr5:96050863..96050877,+p@chr5:96050863..96050877
+
Hg19::chr6:106546834..106546850,+p4@PRDM1
Hg19::chr6:112078784..112078808,-p@chr6:112078784..112078808
-
Hg19::chr6:138115457..138115471,+p@chr6:138115457..138115471
+
Hg19::chr6:167525277..167525292,+p3@CCR6
Hg19::chr6:167527544..167527563,-p@chr6:167527544..167527563
-
Hg19::chr6:167527588..167527601,-p@chr6:167527588..167527601
-
Hg19::chr6:167527627..167527634,-p@chr6:167527627..167527634
-
Hg19::chr6:167527638..167527665,-p@chr6:167527638..167527665
-
Hg19::chr6:167528231..167528238,+p@chr6:167528231..167528238
+
Hg19::chr6:167533072..167533078,-p@chr6:167533072..167533078
-
Hg19::chr6:167535904..167535935,+p6@CCR6
Hg19::chr6:36922228..36922251,+p5@PI16
Hg19::chr6:36922265..36922280,+p4@PI16
Hg19::chr7:130623689..130623700,+p@chr7:130623689..130623700
+
Hg19::chr7:130623728..130623739,+p@chr7:130623728..130623739
+
Hg19::chr7:1966886..1966912,+p@chr7:1966886..1966912
+
Hg19::chr7:1980103..1980127,-p5@MAD1L1
Hg19::chr7:44663908..44663917,+p6@OGDH
Hg19::chr7:5862938..5862949,+p5@ZNF815
Hg19::chr7:8183804..8183812,-p@chr7:8183804..8183812
-
Hg19::chr8:19372703..19372715,-p@chr8:19372703..19372715
-
Hg19::chr8:29938837..29938842,+p@chr8:29938837..29938842
+
Hg19::chr8:30013422..30013433,+p4@DCTN6
Hg19::chr9:123640450..123640455,-p@chr9:123640450..123640455
-
Hg19::chrY:23300437..23300442,+p@chrY:23300437..23300442
+
Hg19::chrY:23300496..23300510,+p@chrY:23300496..23300510
+
Hg19::chrY:23300512..23300525,+p@chrY:23300512..23300525
+
Hg19::chrY:23300567..23300577,+p@chrY:23300567..23300577
+
Hg19::chrY:23317687..23317689,+p@chrY:23317687..23317689
+
Hg19::chrY:23411642..23411670,+p@chrY:23411642..23411670
+
Hg19::chrY:23411694..23411707,+p@chrY:23411694..23411707
+
Hg19::chrY:23411712..23411746,+p@chrY:23411712..23411746
+
Hg19::chrY:23411747..23411768,+p@chrY:23411747..23411768
+
Hg19::chrY:23416616..23416638,+p@chrY:23416616..23416638
+
Hg19::chrY:23416642..23416670,+p@chrY:23416642..23416670
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0042277peptide binding0.000964878835959757
GO:0005887integral to plasma membrane0.000964878835959757
GO:0031226intrinsic to plasma membrane0.000964878835959757
GO:0004945angiotensin type II receptor activity0.000964878835959757
GO:0001595angiotensin receptor activity0.000964878835959757
GO:0019955cytokine binding0.00179502772967683
GO:0015026coreceptor activity0.00229165706264122
GO:0008528peptide receptor activity, G-protein coupled0.00334468907473246
GO:0001653peptide receptor activity0.00334468907473246
GO:0019957C-C chemokine binding0.00334468907473246
GO:0016493C-C chemokine receptor activity0.00334468907473246
GO:0019079viral genome replication0.00450212279542765
GO:0004950chemokine receptor activity0.00582811155172879
GO:0001637G-protein chemoattractant receptor activity0.00582811155172879
GO:0044459plasma membrane part0.00582811155172879
GO:0019956chemokine binding0.00582811155172879
GO:0019058viral infectious cycle0.00889621518374608
GO:0022415viral reproductive process0.00889621518374608
GO:0050164oxoglutarate dehydrogenase (NADP+) activity0.00889621518374608
GO:0045209MAPK phosphatase export from nucleus, leptomycin B sensitive0.00889621518374608
GO:0005896interleukin-6 receptor complex0.00889621518374608
GO:0000093mitotic telophase0.00889621518374608
GO:0045204MAPK export from nucleus0.00889621518374608
GO:0051326telophase0.00889621518374608
GO:0035030phosphoinositide 3-kinase complex, class IA0.00889621518374608
GO:0045208MAPK phosphatase export from nucleus0.00889621518374608
GO:0004186carboxypeptidase C activity0.00889621518374608
GO:0007088regulation of mitosis0.0103676024692682
GO:0006959humoral immune response0.0125281501399269
GO:0019981interleukin-6 binding0.0150081649108715
GO:0004915interleukin-6 receptor activity0.0150081649108715
GO:0043559insulin binding0.0150081649108715
GO:0051323metaphase0.0211820727278141
GO:0000089mitotic metaphase0.0211820727278141
GO:0007166cell surface receptor linked signal transduction0.0252319048871694
GO:0045502dynein binding0.0259455531866042
GO:0043125ErbB-3 class receptor binding0.0259455531866042
GO:0051322anaphase0.02925966667654
GO:0000090mitotic anaphase0.02925966667654
GO:0043560insulin receptor substrate binding0.02925966667654
GO:0045070positive regulation of viral genome replication0.02925966667654
GO:0048524positive regulation of viral reproduction0.0381492264024993
GO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity0.0381492264024993
GO:0048009insulin-like growth factor receptor signaling pathway0.0381492264024993
GO:0005886plasma membrane0.0399546847062203
GO:0006955immune response0.0399546847062203
GO:0045768positive regulation of anti-apoptosis0.0399546847062203
GO:0005869dynactin complex0.0399546847062203
GO:0017046peptide hormone binding0.0431389984972692
GO:0035014phosphoinositide 3-kinase regulator activity0.0431389984972692
GO:0004888transmembrane receptor activity0.0435256927353548
GO:0007165signal transduction0.0470499784077165
GO:0005159insulin-like growth factor receptor binding0.0470499784077165
GO:0004185serine carboxypeptidase activity0.0470499784077165
GO:0016494C-X-C chemokine receptor activity0.0470499784077165
GO:0045086positive regulation of interleukin-2 biosynthetic process0.0470499784077165
GO:0045840positive regulation of mitosis0.0483246687840058
GO:0019958C-X-C chemokine binding0.0483246687840058
GO:0045767regulation of anti-apoptosis0.0483246687840058
GO:0004872receptor activity0.0483246687840058



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte2.25e-40140
hematopoietic stem cell1.70e-34172
angioblastic mesenchymal cell1.70e-34172
hematopoietic lineage restricted progenitor cell9.90e-33124
nongranular leukocyte1.39e-31119
hematopoietic cell2.02e-31182
hematopoietic oligopotent progenitor cell2.09e-31165
hematopoietic multipotent progenitor cell2.09e-31165
lymphoid lineage restricted progenitor cell6.44e-2552
lymphocyte1.07e-2453
common lymphoid progenitor1.07e-2453
T cell6.52e-1525
pro-T cell6.52e-1525
CD14-positive, CD16-negative classical monocyte2.81e-1442
classical monocyte2.57e-1345
mature alpha-beta T cell1.08e-1218
alpha-beta T cell1.08e-1218
immature T cell1.08e-1218
mature T cell1.08e-1218
immature alpha-beta T cell1.08e-1218
myeloid leukocyte1.56e-1276
myeloid cell1.27e-10112
common myeloid progenitor1.27e-10112
myeloid lineage restricted progenitor cell6.22e-1070
granulocyte monocyte progenitor cell1.25e-0971
lymphocyte of B lineage1.38e-0924
pro-B cell1.38e-0924
macrophage dendritic cell progenitor9.86e-0965
CD8-positive, alpha-beta T cell2.54e-0811
monopoietic cell3.01e-0863
monocyte3.01e-0863
monoblast3.01e-0863
promonocyte3.01e-0863
B cell5.43e-0714
Uber Anatomy
Ontology termp-valuen
adult organism8.79e-20115
hemolymphoid system1.09e-16112
hematopoietic system3.91e-16102
blood island3.91e-16102
immune system2.76e-09115
blood3.20e-0915
haemolymphatic fluid3.20e-0915
organism substance3.20e-0915
bone marrow1.02e-0780


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


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