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Coexpression cluster:C1019

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Full id: C1019_occipital_medial_amygdala_caudate_hippocampus_cerebellum_parietal



Phase1 CAGE Peaks

Hg19::chr12:53535758..53535789,+p1@HIGD1AP1
Hg19::chr12:6773757..6773767,+p@chr12:6773757..6773767
+
Hg19::chr13:41745362..41745368,-p1@CALM2P3
Hg19::chr15:90808919..90808930,+p2@NGRN
Hg19::chr17:43697693..43697718,+p3@CRHR1
Hg19::chr2:130737223..130737244,+p1@RAB6C
Hg19::chr7:72569000..72569055,+p1@GTF2IP1
Hg19::chr9:116843080..116843085,+p@chr9:116843080..116843085
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0015056corticotrophin-releasing factor receptor activity0.0169536422372063
GO:0001636corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity0.0169536422372063
GO:0007567parturition0.0226021946511821
GO:0007190adenylate cyclase activation0.0296356973517762
GO:0031281positive regulation of cyclase activity0.0296356973517762
GO:0051349positive regulation of lyase activity0.0296356973517762
GO:0045762positive regulation of adenylate cyclase activity0.0296356973517762
GO:0007189G-protein signaling, adenylate cyclase activating pathway0.0296356973517762
GO:0001633secretin-like receptor activity0.0296356973517762
GO:0045761regulation of adenylate cyclase activity0.0296356973517762
GO:0031279regulation of cyclase activity0.0296356973517762
GO:0051339regulation of lyase activity0.0296356973517762
GO:0042493response to drug0.041008671075108
GO:0007565female pregnancy0.0459801856340502
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messenger0.0459801856340502
GO:0019933cAMP-mediated signaling0.0459801856340502



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube3.99e-1457
neural rod3.99e-1457
future spinal cord3.99e-1457
neural keel3.99e-1457
central nervous system9.04e-1382
anterior neural tube2.04e-1242
regional part of forebrain2.06e-1241
forebrain2.06e-1241
future forebrain2.06e-1241
regional part of brain1.04e-1159
brain5.86e-1169
future brain5.86e-1169
regional part of nervous system6.55e-1194
nervous system6.55e-1194
gray matter7.06e-1134
brain grey matter7.06e-1134
telencephalon3.04e-1034
regional part of telencephalon4.07e-1033
cerebral hemisphere5.16e-1032
bone marrow1.25e-0880
regional part of cerebral cortex2.58e-0822
neural plate2.94e-0886
presumptive neural plate2.94e-0886
adult organism3.52e-08115
cerebral cortex5.33e-0825
pallium5.33e-0825
pre-chordal neural plate6.91e-0861
neocortex1.62e-0720
bone element1.94e-0786
neurectoderm2.12e-0790
skeletal element6.40e-07101
skeletal system6.40e-07101


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.