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Coexpression cluster:C2826

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Full id: C2826_Mast_medial_frontal_occipital_parietal_brain_olfactory



Phase1 CAGE Peaks

Hg19::chr5:67586544..67586558,+p7@PIK3R1
Hg19::chr5:67588391..67588411,+p13@PIK3R1
Hg19::chr5:67588419..67588430,+p29@PIK3R1
Hg19::chr6:147453079..147453129,-p1@ENST00000431143
p1@uc003qlv.2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0035030phosphoinositide 3-kinase complex, class IA0.00167785234899329
GO:0043559insulin binding0.00167785234899329
GO:0043125ErbB-3 class receptor binding0.00209731543624161
GO:0043560insulin receptor substrate binding0.00209731543624161
GO:0048009insulin-like growth factor receptor signaling pathway0.00215723873441994
GO:0017046peptide hormone binding0.00215723873441994
GO:0035014phosphoinositide 3-kinase regulator activity0.00215723873441994
GO:0005159insulin-like growth factor receptor binding0.00230704697986577
GO:0019903protein phosphatase binding0.00272651006711409
GO:0005545phosphatidylinositol binding0.00272651006711409
GO:0005942phosphoinositide 3-kinase complex0.00272651006711409
GO:0019902phosphatase binding0.00272651006711409
GO:0005158insulin receptor binding0.00272651006711409
GO:0046854phosphoinositide phosphorylation0.00272651006711409
GO:0042562hormone binding0.00272651006711409
GO:0046834lipid phosphorylation0.00272651006711409
GO:0008286insulin receptor signaling pathway0.00315831030398737
GO:0030258lipid modification0.00484712900820283
GO:0030384phosphoinositide metabolic process0.00706464146944542
GO:0006650glycerophospholipid metabolic process0.00806967082134867
GO:0032403protein complex binding0.00806967082134867
GO:0019207kinase regulator activity0.00930445393532642
GO:0044445cytosolic part0.0138605194047272
GO:0042277peptide binding0.0138745482705214
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway0.0138745482705214
GO:0006644phospholipid metabolic process0.0138745482705214
GO:0035091phosphoinositide binding0.0155978125776783
GO:0006643membrane lipid metabolic process0.0162991371045062
GO:0007167enzyme linked receptor protein signaling pathway0.0167785234899329
GO:0019899enzyme binding0.0167785234899329
GO:0005125cytokine activity0.0167785234899329
GO:0005543phospholipid binding0.0175125838926175
GO:0005829cytosol0.0285728385313857
GO:0008289lipid binding0.0285728385313857
GO:0044255cellular lipid metabolic process0.036816874400767
GO:0006629lipid metabolic process0.0440902311707681
GO:0005102receptor binding0.0470252131325957



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen

Uber Anatomy
Ontology termp-valuen

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.