MCL coexpression mm9:3343

Phase1 CAGE Peaks

	Short description
Mm9::chr2:30271616..30271667,+	p2@Ppp2r4
Mm9::chr2:30271707..30271741,+	p3@Ppp2r4
Mm9::chr2:32143505..32143516,-	p3@Swi5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019211	phosphatase activator activity	0.000219142058839643
GO:0019888	protein phosphatase regulator activity	0.00255665735312917
GO:0019208	phosphatase regulator activity	0.00255665735312917
GO:0008047	enzyme activator activity	0.011066673971402

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
neural cell	1.18e-16	43
ectodermal cell	1.19e-16	44
neurectodermal cell	1.19e-16	44
non-terminally differentiated cell	3.77e-13	49
neuron	1.04e-12	33
neuronal stem cell	1.04e-12	33
neuroblast	1.04e-12	33
electrically signaling cell	1.04e-12	33
CNS neuron (sensu Vertebrata)	4.28e-10	23
neuroblast (sensu Vertebrata)	4.28e-10	23
electrically responsive cell	2.07e-09	39
electrically active cell	2.07e-09	39

Uber Anatomy

Ontology term	p-value	n
central nervous system	2.72e-20	73
nervous system	5.47e-20	75
ectoderm-derived structure	5.26e-14	95
ectoderm	5.26e-14	95
presumptive ectoderm	5.26e-14	95
neurectoderm	5.58e-14	64
neural plate	5.58e-14	64
presumptive neural plate	5.58e-14	64
gray matter	1.17e-13	34
regional part of nervous system	1.18e-13	54
neural tube	2.33e-13	52
neural rod	2.33e-13	52
future spinal cord	2.33e-13	52
neural keel	2.33e-13	52
brain grey matter	2.39e-11	29
regional part of telencephalon	2.39e-11	29
telencephalon	2.39e-11	29
regional part of forebrain	2.67e-11	39
forebrain	2.67e-11	39
future forebrain	2.67e-11	39
regional part of brain	3.45e-11	46
anterior neural tube	4.23e-11	40
ecto-epithelium	4.87e-11	73
brain	6.83e-11	47
future brain	6.83e-11	47
pre-chordal neural plate	2.32e-10	49
cerebral cortex	1.92e-08	21
cerebral hemisphere	1.92e-08	21
pallium	1.92e-08	21
structure with developmental contribution from neural crest	1.14e-07	92
regional part of cerebral cortex	3.65e-07	17

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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