MCL coexpression mm9:3308

Phase1 CAGE Peaks

	Short description
Mm9::chr2:126317269..126317294,-	p2@Atp8b4
Mm9::chr6:118089112..118089176,-	p1@Csgalnact2
Mm9::chr6:129300351..129300356,+	p8@Clec12a

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0019903	protein phosphatase binding	0.00651840467318639
GO:0019902	phosphatase binding	0.00651840467318639
GO:0050776	regulation of immune response	0.0492439627270993
GO:0002682	regulation of immune system process	0.0492439627270993
GO:0019899	enzyme binding	0.0492439627270993
GO:0009986	cell surface	0.0492439627270993
GO:0005529	sugar binding	0.0492439627270993

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
musculoskeletal system	7.36e-08	32
lung	9.94e-07	14
respiratory tube	9.94e-07	14
respiration organ	9.94e-07	14
pair of lungs	9.94e-07	14
lung primordium	9.94e-07	14
lung bud	9.94e-07	14

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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