MCL coexpression mm9:2283

Phase1 CAGE Peaks

	Short description
Mm9::chr1:134439434..134439455,-	p1@Cntn2
Mm9::chr1:134439459..134439483,-	p2@Cntn2
Mm9::chr1:134439511..134439531,-	p3@Cntn2
Mm9::chr2:124436014..124436021,+	p6@Sema6d

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

GO ID	GO name	FDR corrected p-value
GO:0007399	nervous system development	0.0400587109094456
GO:0001764	neuron migration	0.0476855047073219
GO:0030424	axon	0.0476855047073219
GO:0048731	system development	0.0476855047073219
GO:0048869	cellular developmental process	0.0476855047073219
GO:0030154	cell differentiation	0.0476855047073219
GO:0048856	anatomical structure development	0.0476855047073219
GO:0043005	neuron projection	0.0476855047073219
GO:0048503	GPI anchor binding	0.0476855047073219
GO:0007275	multicellular organismal development	0.0476855047073219

Relative expression of the co-expression cluster over median <br>Analyst:

---

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

---

Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	2.04e-15	23
neuroblast (sensu Vertebrata)	2.04e-15	23
neuron	1.73e-13	33
neuronal stem cell	1.73e-13	33
neuroblast	1.73e-13	33
electrically signaling cell	1.73e-13	33
ectodermal cell	2.22e-12	44
neurectodermal cell	2.22e-12	44
neural cell	3.08e-12	43
electrically responsive cell	1.70e-11	39
electrically active cell	1.70e-11	39
non-terminally differentiated cell	8.40e-11	49

Uber Anatomy

Ontology term	p-value	n
nervous system	6.21e-27	75
ectoderm-derived structure	6.58e-27	95
ectoderm	6.58e-27	95
presumptive ectoderm	6.58e-27	95
central nervous system	1.15e-26	73
neurectoderm	1.68e-24	64
neural plate	1.68e-24	64
presumptive neural plate	1.68e-24	64
regional part of nervous system	2.59e-24	54
structure with developmental contribution from neural crest	1.15e-23	92
ecto-epithelium	2.21e-23	73
neural tube	5.46e-23	52
neural rod	5.46e-23	52
future spinal cord	5.46e-23	52
neural keel	5.46e-23	52
brain	6.31e-20	47
future brain	6.31e-20	47
pre-chordal neural plate	1.30e-19	49
regional part of brain	2.00e-19	46
gray matter	1.20e-17	34
anterior neural tube	1.33e-17	40
regional part of forebrain	5.54e-17	39
forebrain	5.54e-17	39
future forebrain	5.54e-17	39
brain grey matter	5.95e-15	29
regional part of telencephalon	5.95e-15	29
telencephalon	5.95e-15	29
cerebral cortex	1.91e-10	21
cerebral hemisphere	1.91e-10	21
pallium	1.91e-10	21
regional part of cerebral cortex	6.75e-08	17
tube	1.41e-07	114
anatomical conduit	6.23e-07	122

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}