MCL coexpression mm9:2175

Phase1 CAGE Peaks

	Short description
Mm9::chr16:32914180..32914224,+	p1@Lrch3
Mm9::chr1:129670760..129670815,+	p1@Ccnt2
Mm9::chr5:22940253..22940289,+	p1@Mll5
Mm9::chr8:23970000..23970026,+	p1@Myst3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0035019	somatic stem cell maintenance	0.0332110056214622
GO:0048864	stem cell development	0.0332110056214622
GO:0019827	stem cell maintenance	0.0332110056214622
GO:0035162	embryonic hemopoiesis	0.0332110056214622
GO:0048863	stem cell differentiation	0.0332110056214622
GO:0000079	regulation of cyclin-dependent protein kinase activity	0.0332110056214622
GO:0006355	regulation of transcription, DNA-dependent	0.0332110056214622
GO:0006351	transcription, DNA-dependent	0.0332110056214622
GO:0032774	RNA biosynthetic process	0.0332110056214622
GO:0004468	lysine N-acetyltransferase activity	0.0332110056214622
GO:0004402	histone acetyltransferase activity	0.0332110056214622
GO:0045449	regulation of transcription	0.0332110056214622
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0332110056214622
GO:0006350	transcription	0.0332110056214622
GO:0016538	cyclin-dependent protein kinase regulator activity	0.0332110056214622
GO:0010468	regulation of gene expression	0.0332110056214622
GO:0031323	regulation of cellular metabolic process	0.0334140566538751
GO:0000910	cytokinesis	0.0334140566538751
GO:0019222	regulation of metabolic process	0.0349312129114998
GO:0016070	RNA metabolic process	0.0357907590948768
GO:0048568	embryonic organ development	0.0423463223766583
GO:0008080	N-acetyltransferase activity	0.0491289470718693

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
anterior region of body	3.14e-09	43
craniocervical region	1.77e-08	36
respiratory system	7.41e-08	42
respiratory tract	1.31e-07	41

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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