MCL coexpression mm9:1920

Phase1 CAGE Peaks

	Short description
Mm9::chr10:80204967..80205025,-	p1@Ap3d1
Mm9::chr17:34742800..34742807,+	p5@Agpat1
Mm9::chr2:152119567..152119597,+	p2@Tbc1d20
Mm9::chr7:149088266..149088353,-	p1@Tollip

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib	0.0176731013834793
GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	0.0176731013834793
GO:0002475	antigen processing and presentation via MHC class Ib	0.0176731013834793
GO:0051136	regulation of NK T cell differentiation	0.0176731013834793
GO:0001865	NK T cell differentiation	0.0176731013834793
GO:0051138	positive regulation of NK T cell differentiation	0.0176731013834793
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	0.0340698345234604
GO:0016411	acylglycerol O-acyltransferase activity	0.0430463304984218
GO:0046632	alpha-beta T cell differentiation	0.0484853132184813
GO:0019884	antigen processing and presentation of exogenous antigen	0.0484853132184813
GO:0032313	regulation of Rab GTPase activity	0.0484853132184813
GO:0032483	regulation of Rab protein signal transduction	0.0484853132184813
GO:0032482	Rab protein signal transduction	0.0484853132184813
GO:0008374	O-acyltransferase activity	0.0484853132184813
GO:0046631	alpha-beta T cell activation	0.0484853132184813
GO:0005097	Rab GTPase activator activity	0.0484853132184813
GO:0005802	trans-Golgi network	0.0484853132184813
GO:0032318	regulation of Ras GTPase activity	0.0484853132184813

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
non-terminally differentiated cell	1.32e-07	49

Uber Anatomy

Ontology term	p-value	n
regional part of nervous system	9.27e-18	54
central nervous system	7.25e-17	73
nervous system	9.69e-17	75
neural tube	1.17e-16	52
neural rod	1.17e-16	52
future spinal cord	1.17e-16	52
neural keel	1.17e-16	52
brain	5.84e-15	47
future brain	5.84e-15	47
regional part of brain	1.45e-14	46
ectoderm-derived structure	3.38e-14	95
ectoderm	3.38e-14	95
presumptive ectoderm	3.38e-14	95
gray matter	2.71e-13	34
anterior neural tube	3.05e-12	40
adult organism	4.39e-12	51
brain grey matter	6.83e-12	29
regional part of telencephalon	6.83e-12	29
telencephalon	6.83e-12	29
regional part of forebrain	1.12e-11	39
forebrain	1.12e-11	39
future forebrain	1.12e-11	39
neurectoderm	1.50e-11	64
neural plate	1.50e-11	64
presumptive neural plate	1.50e-11	64
ecto-epithelium	1.28e-10	73
cerebral cortex	8.35e-10	21
cerebral hemisphere	8.35e-10	21
pallium	8.35e-10	21
regional part of cerebral cortex	5.10e-09	17
pre-chordal neural plate	1.89e-08	49
occipital lobe	1.07e-07	10
visual cortex	1.07e-07	10
neocortex	1.07e-07	10

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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