MCL coexpression mm9:1808

Phase1 CAGE Peaks

	Short description
Mm9::chr4:82151500..82151505,-	p11@Nfib
Mm9::chr9:74709664..74709671,+	p6@Onecut1
Mm9::chr9:74709682..74709691,+	p3@Onecut1
Mm9::chr9:74709695..74709722,+	p1@Onecut1
Mm9::chr9:74714281..74714296,+	p5@Onecut1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0007492	endoderm development	0.0357320503066181
GO:0003700	transcription factor activity	0.0357320503066181
GO:0030902	hindbrain development	0.0357320503066181
GO:0048513	organ development	0.0357320503066181
GO:0030324	lung development	0.0357320503066181
GO:0030323	respiratory tube development	0.0357320503066181
GO:0048731	system development	0.0357320503066181
GO:0006355	regulation of transcription, DNA-dependent	0.0357320503066181
GO:0006351	transcription, DNA-dependent	0.0357320503066181
GO:0032774	RNA biosynthetic process	0.0357320503066181
GO:0003677	DNA binding	0.0357320503066181
GO:0045449	regulation of transcription	0.0357320503066181
GO:0006006	glucose metabolic process	0.0357320503066181
GO:0048856	anatomical structure development	0.0357320503066181
GO:0030900	forebrain development	0.0357320503066181
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0357320503066181
GO:0006350	transcription	0.0357320503066181
GO:0010468	regulation of gene expression	0.0357320503066181
GO:0008285	negative regulation of cell proliferation	0.0357320503066181
GO:0031323	regulation of cellular metabolic process	0.0357320503066181
GO:0007275	multicellular organismal development	0.0357320503066181
GO:0019222	regulation of metabolic process	0.0357320503066181
GO:0019318	hexose metabolic process	0.0357320503066181
GO:0006260	DNA replication	0.0357320503066181
GO:0005996	monosaccharide metabolic process	0.0357320503066181
GO:0016070	RNA metabolic process	0.0357320503066181
GO:0007420	brain development	0.0465151027743479
GO:0010467	gene expression	0.0465151027743479
GO:0035295	tube development	0.0465151027743479
GO:0003676	nucleic acid binding	0.0465151027743479
GO:0032502	developmental process	0.0479441086384382
GO:0007417	central nervous system development	0.0491106509337442
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0491106509337442
GO:0044262	cellular carbohydrate metabolic process	0.0497486728019959
GO:0006066	alcohol metabolic process	0.0497486728019959

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
liver	9.29e-18	22
epithelial sac	9.29e-18	22
digestive gland	9.29e-18	22
epithelium of foregut-midgut junction	9.29e-18	22
anatomical boundary	9.29e-18	22
hepatobiliary system	9.29e-18	22
foregut-midgut junction	9.29e-18	22
hepatic diverticulum	9.29e-18	22
liver primordium	9.29e-18	22
septum transversum	9.29e-18	22
liver bud	9.29e-18	22
digestive tract diverticulum	1.35e-16	23
sac	1.35e-16	23
exocrine gland	1.46e-14	25
exocrine system	1.46e-14	25
pancreas	4.34e-12	12
endocrine system	1.63e-09	72
immaterial anatomical entity	1.68e-07	79
viscus	7.90e-07	19

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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