MCL coexpression mm9:788

Phase1 CAGE Peaks

	Short description
Mm9::chr11:51449224..51449286,-	p1@Rmnd5b
Mm9::chr11:77029682..77029781,+	p1@Ssh2
Mm9::chr1:82721484..82721518,+	p1@LOC637796 p1@Mff
Mm9::chr2:153117140..153117195,+	p1@Kif3b
Mm9::chr6:88674661..88674745,+	p2@Mgll
Mm9::chr7:107756172..107756206,-	p4@Mrpl48
Mm9::chr7:120512840..120512909,-	p1@Btbd10
Mm9::chr9:108250158..108250257,+	p1@Usp4
Mm9::chr9:22215959..22216020,+	p1@9530077C05Rik

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0047372	acylglycerol lipase activity	0.0430614145619898
GO:0016788	hydrolase activity, acting on ester bonds	0.0431944016503038

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	1.66e-11	23
neuroblast (sensu Vertebrata)	1.66e-11	23
neuron	2.00e-10	33
neuronal stem cell	2.00e-10	33
neuroblast	2.00e-10	33
electrically signaling cell	2.00e-10	33
electrically responsive cell	3.69e-08	39
electrically active cell	3.69e-08	39
ectodermal cell	2.44e-07	44
neurectodermal cell	2.44e-07	44
neural cell	4.22e-07	43

Uber Anatomy

Ontology term	p-value	n
central nervous system	3.92e-19	73
regional part of nervous system	4.39e-19	54
neurectoderm	4.47e-19	64
neural plate	4.47e-19	64
presumptive neural plate	4.47e-19	64
ectoderm-derived structure	5.25e-19	95
ectoderm	5.25e-19	95
presumptive ectoderm	5.25e-19	95
nervous system	6.45e-19	75
ecto-epithelium	3.90e-18	73
neural tube	4.94e-18	52
neural rod	4.94e-18	52
future spinal cord	4.94e-18	52
neural keel	4.94e-18	52
gray matter	8.09e-17	34
pre-chordal neural plate	1.29e-15	49
brain	2.30e-15	47
future brain	2.30e-15	47
regional part of brain	6.40e-15	46
anterior neural tube	1.99e-14	40
brain grey matter	3.37e-14	29
regional part of telencephalon	3.37e-14	29
telencephalon	3.37e-14	29
regional part of forebrain	6.46e-14	39
forebrain	6.46e-14	39
future forebrain	6.46e-14	39
structure with developmental contribution from neural crest	2.32e-13	92
cerebral cortex	2.24e-10	21
cerebral hemisphere	2.24e-10	21
pallium	2.24e-10	21
regional part of cerebral cortex	9.84e-09	17
occipital lobe	1.49e-07	10
visual cortex	1.49e-07	10
neocortex	1.49e-07	10

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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