MCL coexpression mm9:786

Phase1 CAGE Peaks

	Short description
Mm9::chr11:42825666..42825689,+	p@chr11:42825666..42825689 +
Mm9::chr12:104480353..104480358,-	p1@Prima1
Mm9::chr5:138397573..138397584,-	p@chr5:138397573..138397584 -
Mm9::chr5:138404257..138404268,-	p6@Gjc3
Mm9::chr5:138404270..138404284,-	p3@Gjc3
Mm9::chr5:138404315..138404337,-	p1@Gjc3
Mm9::chr6:54222760..54222771,+	p10@Chn2
Mm9::chrX:71002383..71002400,+	p2@Plxnb3
Mm9::chrX:71002408..71002450,+	p1@Plxnb3

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0043495	protein anchor	0.0173122226483318
GO:0019226	transmission of nerve impulse	0.0288442203433327
GO:0043209	myelin sheath	0.0288442203433327
GO:0007267	cell-cell signaling	0.0337350983427982
GO:0042135	neurotransmitter catabolic process	0.0337350983427982
GO:0030054	cell junction	0.0337350983427982
GO:0005243	gap junction channel activity	0.0345760995020743
GO:0022829	wide pore channel activity	0.0345760995020743
GO:0005922	connexon complex	0.0345760995020743
GO:0005921	gap junction	0.0385307930310905
GO:0042552	myelination	0.0385307930310905
GO:0007272	ensheathment of neurons	0.0385307930310905
GO:0008366	axon ensheathment	0.0385307930310905
GO:0042133	neurotransmitter metabolic process	0.0425773023168946
GO:0001508	regulation of action potential	0.0425773023168946
GO:0019992	diacylglycerol binding	0.0456610213962079
GO:0014704	intercalated disc	0.0456610213962079
GO:0019717	synaptosome	0.0498038493125529

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
autonomic neuron	2.62e-09	9
ectodermal cell	8.13e-08	44
neurectodermal cell	8.13e-08	44
neuron	1.24e-07	33
neuronal stem cell	1.24e-07	33
neuroblast	1.24e-07	33
electrically signaling cell	1.24e-07	33
neural cell	3.03e-07	43

Uber Anatomy

Ontology term	p-value	n
ectoderm-derived structure	1.52e-19	95
ectoderm	1.52e-19	95
presumptive ectoderm	1.52e-19	95
nervous system	5.19e-18	75
central nervous system	1.05e-16	73
ecto-epithelium	2.04e-13	73
neurectoderm	3.13e-12	64
neural plate	3.13e-12	64
presumptive neural plate	3.13e-12	64
peripheral nervous system	1.16e-10	11
structure with developmental contribution from neural crest	6.02e-10	92
regional part of nervous system	1.12e-09	54
autonomic nervous system	2.62e-09	9
neural tube	1.46e-08	52
neural rod	1.46e-08	52
future spinal cord	1.46e-08	52
neural keel	1.46e-08	52
occipital lobe	7.31e-08	10
visual cortex	7.31e-08	10
neocortex	7.31e-08	10

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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