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Coexpression cluster:C4603

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Full id: C4603_non_acute_Hodgkin_chronic_Placental_thymus_rhabdomyosarcoma



Phase1 CAGE Peaks

Hg19::chr6:41909466..41909520,-p1@CCND3
Hg19::chr6:41909533..41909560,-p3@CCND3
Hg19::chr6:41909561..41909621,-p4@CCND3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
mesodermal cell5.29e-12121
somatic cell7.67e-12588
animal cell2.99e-11679
eukaryotic cell2.99e-11679
native cell5.19e-10722
contractile cell1.15e-0859
smooth muscle cell5.93e-0843
smooth muscle myoblast5.93e-0843
muscle precursor cell6.97e-0858
myoblast6.97e-0858
multi-potent skeletal muscle stem cell6.97e-0858
muscle cell1.00e-0755
Uber Anatomy
Ontology termp-valuen
splanchnic layer of lateral plate mesoderm3.92e-1083
cardiovascular system4.66e-10109
lateral plate mesoderm7.92e-10203
circulatory system8.42e-10112
vasculature1.87e-0978
vascular system1.87e-0978
epithelial vesicle2.08e-0978
epithelial tube open at both ends4.68e-0959
blood vessel4.68e-0959
blood vasculature4.68e-0959
vascular cord4.68e-0959
epithelial tube7.33e-09117
vessel2.87e-0868
mesoderm8.94e-08315
mesoderm-derived structure8.94e-08315
presumptive mesoderm8.94e-08315
artery3.71e-0742
arterial blood vessel3.71e-0742
arterial system3.71e-0742
somite5.36e-0771
presomitic mesoderm5.36e-0771
presumptive segmental plate5.36e-0771
dermomyotome5.36e-0771
trunk paraxial mesoderm5.36e-0771
paraxial mesoderm5.64e-0772
presumptive paraxial mesoderm5.64e-0772
dense mesenchyme tissue6.78e-0773
unilaminar epithelium9.17e-07148
Disease
Ontology termp-valuen
leukemia5.31e-1639
hematologic cancer3.34e-1551
immune system cancer3.34e-1551
myeloid leukemia1.42e-1331


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0191012285029429
CEBPB#105137.971147625824820.001974187055288560.0115722131597509
E2F1#186934.907389214879320.008460985347239390.0327425836920237
E2F4#1874312.66806031528440.0004917987006298980.00438774683880796
E2F6#187635.017155731697390.00791769806886330.0324077625260234
EGR1#195834.988179094810140.008056488137383440.0322268782634413
ELF1#199734.258097958807540.01295179875054610.0464676368845168
ELK4#2005316.2356816584680.0002336043955745990.00256329160216595
ETS1#211339.728760922202340.001085840092584840.00764951456522548
FOS#235338.99795530889440.001372499272417130.00901411467186345
GABPB1#255337.067683836182170.002832212825417420.0154752262882584
GATA1#2623313.56030814380040.0004009615963782630.00389290956253132
HMGN3#932438.178547723350590.001827766942164210.0109123736164574
HSF1#32973164.2906666666672.24910326529255e-071.19235581687253e-05
IRF1#365937.63716375356390.002244692747297240.0128668202982973
MXI1#460139.96157162875930.001011470541259020.00722996179991452
NFYB#4801316.75979325353650.0002123649923296180.00246572400599366
PPARGC1A#108913350.0511363636362.31814761783079e-081.63695077118749e-06
SIN3A#2594235.408884726815140.006318961977991520.027811794429578
SP1#666735.69838137814090.005403962701712170.0247754372521562
STAT3#6774310.51946499715420.0008589184530415310.00645217466138276
YY1#752834.911170749853860.008441455341808260.0331049211236196
ZBTB7A#5134137.35190930787590.002516255860282270.0140833465054673



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.