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Coexpression cluster:C4217

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Full id: C4217_Neutrophils_Basophils_Natural_CD8_Eosinophils_Hair_Fibroblast



Phase1 CAGE Peaks

Hg19::chr2:28616337..28616355,+p2@FOSL2
Hg19::chr2:28616358..28616380,+p3@FOSL2
Hg19::chr2:28616471..28616478,+p7@FOSL2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
musculoskeletal system8.25e-18167
lateral plate mesoderm4.98e-16203
mesoderm7.10e-16315
mesoderm-derived structure7.10e-16315
presumptive mesoderm7.10e-16315
bone marrow1.34e-1076
anatomical system7.55e-10624
anatomical group1.50e-09625
hematopoietic system1.67e-0998
blood island1.67e-0998
skeletal muscle tissue3.10e-0962
striated muscle tissue3.10e-0962
myotome3.10e-0962
hemolymphoid system4.03e-09108
bone element4.26e-0982
muscle tissue5.10e-0964
musculature5.10e-0964
musculature of body5.10e-0964
dense mesenchyme tissue6.59e-0973
somite7.11e-0971
presomitic mesoderm7.11e-0971
presumptive segmental plate7.11e-0971
dermomyotome7.11e-0971
trunk paraxial mesoderm7.11e-0971
skeletal element7.69e-0990
skeletal system9.66e-09100
multilaminar epithelium9.80e-0983
epithelial vesicle1.49e-0878
paraxial mesoderm1.52e-0872
presumptive paraxial mesoderm1.52e-0872
immune system2.14e-0893
multi-cellular organism4.08e-08656
systemic artery1.28e-0733
systemic arterial system1.28e-0733
artery1.91e-0742
arterial blood vessel1.91e-0742
arterial system1.91e-0742


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190498191640487
E2F1#186934.907389214879320.008460985347239390.0326337561370978
EGR1#195834.988179094810140.008056488137383440.0321493032469887
SMARCB1#6598318.25271578115740.000164397760679890.0020347875951229



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.