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Coexpression cluster:C582

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Full id: C582_Smooth_tenocyte_mesenchymal_leiomyoma_Fibroblast_Olfactory_Aortic



Phase1 CAGE Peaks

Hg19::chr10:33200555..33200575,-p1@AF086249
Hg19::chr10:33200591..33200603,-p2@AF086249
Hg19::chr10:33200884..33200910,+p@chr10:33200884..33200910
+
Hg19::chr10:33200984..33201060,-p5@ITGB1
Hg19::chr10:33211224..33211280,-p@chr10:33211224..33211280
-
Hg19::chr10:33212555..33212600,-p9@ITGB1
Hg19::chr10:33212601..33212662,-p6@ITGB1
Hg19::chr10:33217106..33217178,-p@chr10:33217106..33217178
-
Hg19::chr10:33218785..33218853,-p@chr10:33218785..33218853
-
Hg19::chr10:33218882..33218915,-p@chr10:33218882..33218915
-
Hg19::chr10:33218945..33218966,-p@chr10:33218945..33218966
-
Hg19::chr10:33221480..33221527,-p7@ITGB1
Hg19::chr19:14732681..14732704,-p@chr19:14732681..14732704
-
Hg19::chr7:128410308..128410334,+p@chr7:128410308..128410334
+
Hg19::chr7:128410396..128410415,+p@chr7:128410396..128410415
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0031594neuromuscular junction0.0102437301306959
GO:0042383sarcolemma0.0136583068409278
GO:0001726ruffle0.0144462860817506
GO:0008305integrin complex0.0144462860817506
GO:0031252leading edge0.0144462860817506
GO:0006968cellular defense response0.0144462860817506
GO:0048770pigment granule0.0144462860817506
GO:0042470melanosome0.0144462860817506
GO:0007229integrin-mediated signaling pathway0.0144462860817506
GO:0007160cell-matrix adhesion0.0144462860817506
GO:0031589cell-substrate adhesion0.0144462860817506
GO:0046982protein heterodimerization activity0.0144462860817506
GO:0043235receptor complex0.0144462860817506
GO:0007156homophilic cell adhesion0.0251215286538494
GO:0016477cell migration0.0265198791161348
GO:0042995cell projection0.0284300626091052
GO:0016023cytoplasmic membrane-bound vesicle0.0284300626091052
GO:0016337cell-cell adhesion0.0284300626091052
GO:0031988membrane-bound vesicle0.0284300626091052
GO:0042802identical protein binding0.0284300626091052
GO:0046983protein dimerization activity0.0284300626091052
GO:0051674localization of cell0.0284300626091052
GO:0006928cell motility0.0284300626091052
GO:0031410cytoplasmic vesicle0.0295019427764041
GO:0031982vesicle0.0295019427764041
GO:0006952defense response0.0383483230533743



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
fibroblast7.64e-1476
animal cell4.66e-11679
eukaryotic cell4.66e-11679
muscle precursor cell8.57e-0958
myoblast8.57e-0958
multi-potent skeletal muscle stem cell8.57e-0958
embryonic cell8.60e-08250
muscle cell8.83e-0855
mesodermal cell1.03e-07121
skin fibroblast1.40e-0723
electrically responsive cell3.92e-0761
electrically active cell3.92e-0761
somatic cell3.92e-07588
preadipocyte4.48e-0712
vascular associated smooth muscle cell5.32e-0732
smooth muscle cell7.33e-0743
smooth muscle myoblast7.33e-0743
Disease
Ontology termp-valuen
ovarian cancer8.15e-0914


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
GATA1#262354.520102714600150.003491678030095980.0177341517183871



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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