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Coexpression cluster:C491

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Full id: C491_Adipocyte_dura_aorta_Preadipocyte_heart_Fibroblast_epididymis



Phase1 CAGE Peaks

Hg19::chr10:22002796..22002833,+p@chr10:22002796..22002833
+
Hg19::chr10:85462978..85462980,-p@chr10:85462978..85462980
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Hg19::chr12:15034824..15034835,+p@chr12:15034824..15034835
+
Hg19::chr12:15034857..15034886,-p@chr12:15034857..15034886
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Hg19::chr12:15034903..15034944,-p@chr12:15034903..15034944
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Hg19::chr12:15034956..15034967,-p@chr12:15034956..15034967
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Hg19::chr12:15034968..15034990,-p@chr12:15034968..15034990
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Hg19::chr12:15035012..15035043,-p@chr12:15035012..15035043
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Hg19::chr12:15035058..15035069,+p@chr12:15035058..15035069
+
Hg19::chr12:15035074..15035085,-p@chr12:15035074..15035085
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Hg19::chr12:15035100..15035219,-p@chr12:15035100..15035219
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Hg19::chr12:15035939..15035972,-p@chr12:15035939..15035972
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Hg19::chr12:15038779..15038798,-p1@MGP
Hg19::chr12:15154767..15154778,+p1@ENST00000542689
Hg19::chr1:231005253..231005263,-p15@C1orf198
Hg19::chr4:84114490..84114492,-p@chr4:84114490..84114492
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Hg19::chr5:150407833..150407850,-p8@CU690655
Hg19::chr9:93101022..93101028,+p@chr9:93101022..93101028
+
Hg19::chrX:102757802..102757810,-p1@RAB40A


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0008147structural constituent of bone0.012949936385265
GO:0051592response to calcium ion0.012949936385265
GO:0048306calcium-dependent protein binding0.012949936385265
GO:0001502cartilage condensation0.012949936385265
GO:0030500regulation of bone mineralization0.012949936385265
GO:0009612response to mechanical stimulus0.014713887167521
GO:0030278regulation of ossification0.014713887167521
GO:0030282bone mineralization0.014713887167521
GO:0046850regulation of bone remodeling0.0156938887077954
GO:0010038response to metal ion0.0168662108026289
GO:0051216cartilage development0.0168662108026289
GO:0007584response to nutrient0.0168662108026289
GO:0030324lung development0.0168662108026289
GO:0010035response to inorganic substance0.0168662108026289
GO:0030323respiratory tube development0.0168662108026289
GO:0031667response to nutrient levels0.0220578331918385
GO:0009991response to extracellular stimulus0.0228343265070251
GO:0009725response to hormone stimulus0.0248296325447801
GO:0031214biomineral formation0.0258705156162679
GO:0001503ossification0.0258705156162679
GO:0046849bone remodeling0.026875288854357
GO:0048771tissue remodeling0.0280549957385919
GO:0035295tube development0.0298312385764
GO:0005201extracellular matrix structural constituent0.0298312385764
GO:0050954sensory perception of mechanical stimulus0.0298312385764
GO:0007605sensory perception of sound0.0298312385764
GO:0009628response to abiotic stimulus0.0358904978638971
GO:0001501skeletal development0.0438092210678937



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
adipocyte of omentum tissue2.77e-133
fat cell2.02e-0915
adipocyte of breast2.88e-092
Uber Anatomy
Ontology termp-valuen
adult organism3.61e-17114
omentum8.56e-176
peritoneum8.56e-176
abdominal cavity8.56e-176
visceral peritoneum8.56e-176
perirenal fat2.09e-092
heart1.17e-0824
primitive heart tube1.17e-0824
primary heart field1.17e-0824
anterior lateral plate mesoderm1.17e-0824
heart tube1.17e-0824
heart primordium1.17e-0824
cardiac mesoderm1.17e-0824
cardiogenic plate1.17e-0824
heart rudiment1.17e-0824
open tracheal system trachea2.81e-082
cavity lining3.26e-0812
serous membrane3.26e-0812
body cavity6.58e-0846
subdivision of trunk7.08e-08112
body cavity precursor8.97e-0854
anatomical space1.31e-0795
primary circulatory organ1.49e-0727
compound organ1.49e-0768
body cavity or lining2.73e-0749


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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