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Coexpression cluster:C400

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Full id: C400_acute_leukemia_chronic_myelodysplastic_NK_pancreas_duodenum



Phase1 CAGE Peaks

Hg19::chr11:10066331..10066341,-p14@SBF2
Hg19::chr13:21651405..21651425,+p@chr13:21651405..21651425
+
Hg19::chr13:44990601..44990610,-p@chr13:44990601..44990610
-
Hg19::chr13:91807411..91807446,+p@chr13:91807411..91807446
+
Hg19::chr15:91832784..91832813,+p@chr15:91832784..91832813
+
Hg19::chr17:73494290..73494299,+p@chr17:73494290..73494299
+
Hg19::chr17:73494308..73494321,+p@chr17:73494308..73494321
+
Hg19::chr1:120342510..120342533,-p@chr1:120342510..120342533
-
Hg19::chr1:200119992..200120017,+p@chr1:200119992..200120017
+
Hg19::chr20:11561982..11561988,-p@chr20:11561982..11561988
-
Hg19::chr20:11562071..11562078,-p@chr20:11562071..11562078
-
Hg19::chr21:40361134..40361189,-p@chr21:40361134..40361189
-
Hg19::chr2:117207734..117207758,+p@chr2:117207734..117207758
+
Hg19::chr3:71808686..71808697,-p@chr3:71808686..71808697
-
Hg19::chr4:77177483..77177500,+p@chr4:77177483..77177500
+
Hg19::chr4:77177512..77177526,+p@chr4:77177512..77177526
+
Hg19::chr4:80118672..80118679,+p2@ENST00000512130
Hg19::chr4:80118699..80118734,+p1@ENST00000512130
Hg19::chr4:80127830..80127850,+p@chr4:80127830..80127850
+
Hg19::chr5:150155709..150155730,-p@chr5:150155709..150155730
-
Hg19::chr6:142507003..142507014,+p@chr6:142507003..142507014
+
Hg19::chr6:156491058..156491081,-p@chr6:156491058..156491081
-
Hg19::chr6:156491142..156491148,-p@chr6:156491142..156491148
-
Hg19::chr6:156491164..156491167,-p@chr6:156491164..156491167
-
Hg19::chr8:54090128..54090133,+p1@ENST00000529837
Hg19::chr8:94710802..94710816,+p3@FAM92A1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0051262protein tetramerization0.010518466187841
GO:0046839phospholipid dephosphorylation0.010518466187841
GO:0019902phosphatase binding0.010518466187841
GO:0042552myelination0.010518466187841
GO:0007272ensheathment of neurons0.010518466187841
GO:0008366axon ensheathment0.010518466187841
GO:0001508regulation of action potential0.010518466187841
GO:0030258lipid modification0.010518466187841
GO:0004437inositol or phosphatidylinositol phosphatase activity0.010518466187841
GO:0051259protein oligomerization0.010518466187841
GO:0005774vacuolar membrane0.010518466187841
GO:0044437vacuolar part0.010518466187841
GO:0019208phosphatase regulator activity0.0124401090490811
GO:0042803protein homodimerization activity0.0222578257724849
GO:0005773vacuole0.0306350327720868
GO:0035091phosphoinositide binding0.0309390821853291
GO:0016311dephosphorylation0.0313839018321994
GO:0019899enzyme binding0.0313839018321994
GO:0019226transmission of nerve impulse0.0313839018321994
GO:0005543phospholipid binding0.0313839018321994
GO:0006461protein complex assembly0.0313839018321994
GO:0042802identical protein binding0.0313839018321994
GO:0046983protein dimerization activity0.0313839018321994
GO:0016791phosphoric monoester hydrolase activity0.0359928764865183
GO:0042578phosphoric ester hydrolase activity0.043919653289134
GO:0008289lipid binding0.043919653289134
GO:0007267cell-cell signaling0.0467487386126265



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

Uber Anatomy
Ontology termp-valuen
temporal lobe8.99e-116
Disease
Ontology termp-valuen
myeloid leukemia1.20e-0931
chronic leukemia1.47e-098
leukemia6.83e-0839


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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