MCL coexpression mm9:2546

Phase1 CAGE Peaks

	Short description
Mm9::chr10:21602020..21602045,+	p8@Sgk1
Mm9::chr4:154719749..154719758,-	p4@Prkcz
Mm9::chr9:81527119..81527171,-	p@chr9:81527119..81527171 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0045179	apical cortex	0.00942285039103686
GO:0004700	atypical protein kinase C activity	0.00942285039103686
GO:0004674	protein serine/threonine kinase activity	0.0145566028350312
GO:0004672	protein kinase activity	0.0145566028350312
GO:0006468	protein amino acid phosphorylation	0.0145566028350312
GO:0016773	phosphotransferase activity, alcohol group as acceptor	0.0145566028350312
GO:0016310	phosphorylation	0.0145566028350312
GO:0004697	protein kinase C activity	0.0145566028350312
GO:0006793	phosphorus metabolic process	0.0145566028350312
GO:0006796	phosphate metabolic process	0.0145566028350312
GO:0001565	phorbol ester receptor activity	0.0145566028350312
GO:0016301	kinase activity	0.0153779896151013
GO:0016772	transferase activity, transferring phosphorus-containing groups	0.0185871248635674
GO:0044448	cell cortex part	0.0188322775505494
GO:0005524	ATP binding	0.0221164002125192
GO:0043687	post-translational protein modification	0.0221164002125192
GO:0032559	adenyl ribonucleotide binding	0.0221164002125192
GO:0019992	diacylglycerol binding	0.0221164002125192
GO:0030554	adenyl nucleotide binding	0.0221164002125192
GO:0005938	cell cortex	0.0221164002125192
GO:0006464	protein modification process	0.0249193206754661
GO:0043412	biopolymer modification	0.0249193206754661
GO:0000226	microtubule cytoskeleton organization and biogenesis	0.0249193206754661
GO:0032553	ribonucleotide binding	0.0249193206754661
GO:0032555	purine ribonucleotide binding	0.0249193206754661
GO:0005923	tight junction	0.0249519135053777
GO:0017076	purine nucleotide binding	0.0249519135053777
GO:0045177	apical part of cell	0.0258595973926225
GO:0016740	transferase activity	0.0264410244880735
GO:0043296	apical junction complex	0.0270002977994341
GO:0016327	apicolateral plasma membrane	0.0270002977994341
GO:0000166	nucleotide binding	0.0270002977994341
GO:0005911	intercellular junction	0.0426574809500271
GO:0005768	endosome	0.0455243430674482
GO:0007017	microtubule-based process	0.0471576119431688
GO:0044267	cellular protein metabolic process	0.0486033701908296
GO:0044260	cellular macromolecule metabolic process	0.0487909349677067

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
CNS neuron (sensu Vertebrata)	5.48e-16	23
neuroblast (sensu Vertebrata)	5.48e-16	23
neuron	6.44e-10	33
neuronal stem cell	6.44e-10	33
neuroblast	6.44e-10	33
electrically signaling cell	6.44e-10	33
electrically responsive cell	4.45e-07	39
electrically active cell	4.45e-07	39

Uber Anatomy

Ontology term	p-value	n
neurectoderm	2.14e-29	64
neural plate	2.14e-29	64
presumptive neural plate	2.14e-29	64
regional part of nervous system	1.50e-28	54
neural tube	4.41e-27	52
neural rod	4.41e-27	52
future spinal cord	4.41e-27	52
neural keel	4.41e-27	52
ecto-epithelium	9.86e-26	73
central nervous system	2.87e-24	73
ectoderm-derived structure	4.47e-24	95
ectoderm	4.47e-24	95
presumptive ectoderm	4.47e-24	95
nervous system	9.12e-24	75
pre-chordal neural plate	1.26e-23	49
brain	1.84e-22	47
future brain	1.84e-22	47
regional part of brain	9.83e-22	46
gray matter	1.18e-20	34
anterior neural tube	4.09e-20	40
regional part of forebrain	3.58e-19	39
forebrain	3.58e-19	39
future forebrain	3.58e-19	39
structure with developmental contribution from neural crest	3.03e-18	92
brain grey matter	2.64e-16	29
regional part of telencephalon	2.64e-16	29
telencephalon	2.64e-16	29
cerebral cortex	1.21e-10	21
cerebral hemisphere	1.21e-10	21
pallium	1.21e-10	21
regional part of cerebral cortex	2.12e-09	17
occipital lobe	4.44e-09	10
visual cortex	4.44e-09	10
neocortex	4.44e-09	10
posterior neural tube	1.89e-07	12
chordal neural plate	1.89e-07	12
basal ganglion	4.40e-07	8
nuclear complex of neuraxis	4.40e-07	8
aggregate regional part of brain	4.40e-07	8
collection of basal ganglia	4.40e-07	8
cerebral subcortex	4.40e-07	8

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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